1.
Bioorg Med Chem
; 21(5): 1078-81, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23352483
RESUMO
Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure.