RESUMO
(+/-)-Thioridazine and (+/-)-desmethylthioridazine have been oxidized to produce a number of chiral sulphoxide and amine oxide compounds. Diastereoisomeric isomers were separated by thin-layer and high performance liquid chromatography. Thioridazine-5-sulphoxide, N-desmethylthioridazine-5-sulphoxide and thioridazine-N-oxide diastereoisomers were found to be thioridazine metabolites following dosing in rats or after in-vitro incubation with rat liver homogenate.
Assuntos
Tioridazina/análogos & derivados , Tioridazina/isolamento & purificação , Animais , Biotransformação , Cromatografia Líquida de Alta Pressão , Cromatografia em Camada Fina , Técnicas In Vitro , Fígado/metabolismo , Espectroscopia de Ressonância Magnética , Masculino , Ratos , Ratos Endogâmicos , Estereoisomerismo , Tioridazina/metabolismoRESUMO
An improved preparation of photobilirubin II in ammoniacal methanol is described. Evidence is presented which distinguishes between the two structures proposed earlier for photobilirubin II in favour of the cycloheptadienyl structure. Nuclear-Overhauser-enhancement measurements with bilirubin IX alpha and photobilirubin II in dimethyl sulphoxide are complicated by the occurrence of negative and zero effects. The partition coefficient of photobilirubin II between chloroform and phosphate buffer (pH 7.4) is 0.67.
