Biopsychosocial Variables in Male Schizophrenic Patients: A Comprehensive Comparison with Healthy Controls.

OBJECTIVE: this study aims to comprehensively compare neuropsychological, psychopathological, anthropometric, biochemical, pharmacological, and lifestyle variables between 27 male schizophrenic patients (SZ group) and 30 age- and sex-matched healthy male controls (HC group). METHODS: participants underwent a battery of neuropsychological tests including the Trail Making Test (TMT), Stroop Color-Word Interference Test, and Verbal Fluency Test. Psychopathological symptoms in the SZ group were evaluated using the Positive and Negative Syndrome Scale (PANSS). Anthropometric measurements such as body weight, height, BMI, and waist circumference were taken. Biochemical markers measured included fasting glucose, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and fasting insulin. Lifestyle factors were assessed through a questionnaire for the study of views and eating habits of people aged 16 to 65. RESULTS: the HC group outperformed the SZ group in the TMT_A test and the Stroop test, but no significant differences were observed in the TMT_B test or in phonemic fluency tests. No correlation was found between age and PANSS scores within the SZ group. Anthropometrically, the SZ group had higher body weight, waist circumference, and BMI, with no difference in height. Biochemically, the HC group had higher HDL cholesterol levels but lower insulin and insulin resistance indices. Pharmacological assessment showed a more significant impact on body weight among SZ patients taking second-generation antipsychotics. Lifestyle factors such as diet and screen time were comparable between groups, but the SZ group reported longer sleep duration and lower leisure time activity. CONCLUSIONS: our study highlights distinct neuropsychological, pharmacological, anthropometric, and biochemical differences between male schizophrenic patients and healthy controls. The results underscore the complexity of schizophrenia and point toward the need for a multi-faceted approach to its management and understanding.

Neutropenia in a schizophrenia patient following combined lurasidone and paliperidone therapy: a case report.

Purpose: Lurasidon is a relatively new, second-generation antipsychotic drug with an interesting receptor profile. It is considered to be safe and has a low risk of side effects. It is a substance with a multi-receptor mechanism of action: it mainly blocks dopaminergic D2 and serotonergic 5-HT2A receptors. According to the Summary of Product Characteristics, the adverse reaction of neutropenia was too rare to enable the estimation of its frequency. Case description: A case of 39-year-old patient is presented in the article, diagnosed with paranoid schizophrenia, who developed neutropenia as a result of treatment with lurasidone. After the discontinuation of lurasidone and recommended supplementation, the blood test results gradually improved and finally reached the normal range. Comment: This case report shows the need for regular monitoring of blood cell parameters in patients treated with second-generation antipsychotics, as there is a risk of neutrocytopenia or even agranulocitosis.

The Risk of Methylphenidate Pharmacotherapy for Adults with ADHD.

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders. It was once thought to be a disorder affecting only children, but in those undiagnosed in childhood, symptoms do not disappear with age. There is now a growing recognition of the late diagnosis and treatment of adults with ADHD. The first-line drug in pharmacotherapy is methylphenidate, and information about its adverse effects, when used by adults, has not been as extensively described as in children. The aim of this article was to review the literature describing the risks of methylphenidate therapy for adults with ADHD. A total of 19 articles-15 clinical trials and 4 case reports presenting rare side effects resulting from methylphenidate therapy, such as reversible ischemic stroke, myocardial infarction, and psychotic episodes, were analyzed. The analysis from clinical trials included 3458 adult patients with ADHD and described the most common side effects, psychiatric adverse events, effects of methylphenidate treatment on sleep, laboratory results, body mass, and cardiovascular symptoms. Methylphenidate treatment is well tolerated, with side effects described, according to severity, as mild to moderate. We conclude that pharmacotherapy is not risk-free and methylphenidate, due to its side effects, may not be the first drug of choice for every patient.

Exercise addiction symptoms and mental health during the forced exercises deprivation in greatest COVID-19 pandemic restrictions in Poland. / Objawy uzaleznienia od cwiczen a zdrowie psychiczne w sytuacji wymuszonego ograniczenia treningów w trakcie najwiekszych restrykcji w zwiazku z pandemia COVID-19 w Polsce.

OBJECTIVES: The paper describes the relationship between the symptoms of exercise addiction, behavioral strategies in situations of limited workout possibilities and mental health state in exercising individuals. METHODS: The study included 391 participants, 286 women (73.1%) and 105 men (26.9%), aged 18 to 68 years. The respondents were surveyed online after 17-19 days of barriers to routine training due to greatest COVID-19 restrictions in Poland. Subjects completed the Exercise Dependence Scale, General Health Questionnaire - 28 (GHQ-28) and questionnaires enabling the collection of demographic and clinical data as well as data related to exercise behaviors. RESULTS: The variables related to exercise addiction and some related to behavioral changes are predictors of mental health, especially in terms of anxiety, insomnia and somatic symptoms. All the introduced variables accounted for 27.4% to 43.7% of the variation in the mental health status of the subjects, depending on GHQ subscales. Breaking the restriction rules by outdoor training protected against symptoms of psychological disorders, especially in relation to somatic symptoms (Beta = -0.23; p< 0.001). Individual assessment of stress induction in a given situation was a predictor of results in all GHQ subscales, which was the strongest for symptoms of anxiety and insomnia (Beta = 0.37; p< 0.001). CONCLUSIONS: Individuals with features of exercise addiction are at risk of deterioration of their well-being during forced abstinence. In addition, the subjective level of stress induction in a given situation is an important determinant that conditions psychological well-being, especially the aggravation of depressive symptoms. People who ignore restrictions and have low levels of stress, experience lower psychological costs.

Ubiquitin-specific protease 7 as a potential therapeutic target in dogs with hematopoietic malignancies.

BACKGROUND: Ubiquitin-specific protease 7 (USP7) belongs to the group of deubiquitinating enzymes (DUBs), which remove ubiquitin which controls various cellular processes such as chromosome segregation, DNA repair, gene expression, protein localization, kinase activity, protein degradation, cell cycle progression, and apoptosis. It is critical for several important functions in the cell, and therefore dysregulation of USP7 can contribute to tumorigenesis. OBJECTIVES: Alterations in the USP7 protein have been identified in various malignancies of humans. Our aim was to examine whether USP7 could be a potential therapeutic target in hematopoietic cancers of dogs. METHODS: The expression level of USP7 in lymphocytes from healthy dogs and canine lymphoma cells was determined, and the effect of USP7 inhibition on the vital functions of canine cancer cells was examined. RESULTS: We showed that USP7 was overexpressed in lymphomas in dogs. The USP7 inhibitor P5091 has selective cytotoxic activity in canine lymphoma and leukemia cell lines. Our results indicate that inhibition of USP7 leads to a disruption of cell cycle progression, and triggers DNA damage and apoptosis. The observed proapoptotic effect of the USP7 inhibitor most likely is not dependent on the p53 pathway. CONCLUSIONS AND CLINICAL IMPORTANCE: Our results suggest that USP7 could be explored as a potential therapeutic target in dogs with lymphoma. The effectiveness of USP7 inhibition in malignant cells is predicted to be independent of their p53 status.

Can't get enough. Addiction to physical exercises: phenomenon, diagnostic criteria, etiology, therapy and research challenges. / Co za duzo to niezdrowo. Uzaleznienie od cwiczen fizycznych: zjawisko, kryteria diagnostyczne, etiologia, terapia, wyzwania badawcze.

Regular exercising has many health benefits and is rightly seen as positive, socially acceptable behavior. However, for the same reason, there is a high risk that patients and clinicians may overlook the danger of exercise addiction that causes harm in the somatic, emotional and interpersonal spheres. The current state of knowledge did not allow the inclusion of exercise addiction as a specific category in the current classifications ICD-10, ICD-11 and DSM-5. However, this disorder meets the general criteria for addiction and is therefore included in the canon of behavioral addiction. The purpose of the article is to present knowledge that will help in recognizing and understanding the physiological and psychological mechanisms associated with addiction to physical exercise and will introduce available methods of psychotherapy. The article is of areview nature and presents terminology, recognition criteria, epidemiological data, mechanisms of developing addiction, the most popular tools helpful in screening diagnosis or self-diagnosis and risk factors of developing exercise addiction. The authors also took into account the specific location of exercise addiction in the context of other mental disorders, controversies, inconsistencies in research results, and gaps in scientific data related to the discussed phenomenon. The summary proposes further research development pathways.

[Memory hallucinations as an untypical symptom in schizoaffective disorders--legal doubts]. / Omamy pamieciowe jako nietypowy objaw w zaburzeniach schizoafektywnych--watpliwosci prawne.

The authors have described diagnostic difficulties of patient with memory hallucinations. A 45-year-old man, previously hospitalized many times on the Psychiatry Department was admitted to the Psychiatry Department after another suicidal attempt. During the examination the patient has confessed that he had committed a crime. This cause that doctor was on the horns of a dilemma of writing his statement in case history. Psychiatric and psychological diagnostics have showed memory hallucinations. Paying attention to legal aspect allowed to solve the problem. The frequency of occurrence of memory hallucinations still has been the question today.