Comparing PM2.5, respirable dust, and total dust fractions using real-time and gravimetric samples in an exposure chamber study.

Using an exposure chamber, we investigate the precision of the DustTrak DRX monitor by comparing its results to those obtained from taking traditional gravimetric samples of two stone minerals commonly used in asphalt and lactose powder. We also discuss the possibility of using real-time monitors such as DustTrak DRX for occupational exposure monitoring purposes. The results are based on 19 days of experiment, each day with measurements collected over 4 h. Compared to the gravimetric samples, the DustTrak DRX overestimated the PM2.5 and respirable dust concentrations, while it underestimated the total dust concentration by a factor of nearly two. However, the ratios, being done for more than one material, between the DustTrak DRX and the gravimetric sample readings varied daily and across the different exposure materials. Real-time sensors have the potential to excel at identifying exposure sources, evaluating the measured control efficiency, visualizing variations in exposure to motivate workers, and contributing to the identification of measures to be implemented to reduce exposure. For total dust, a correction factor of at least two should be used to bring its readings up to those for the corresponding gravimetric samples. Also, if the DustTrak DRX is used in the initial profiling of occupational exposure, the exposure could be considered acceptable if the readings are well below the occupational exposure limit (OELs) after correction. If the DustTrak DRX readings, after correction, is close to, or above, the accepted exposure concentrations, more thorough approaches would be required to validate the exposure.

Association between exposure to different stone aggregates from asphalt and blood coagulability: A human exposure chamber study.

A large fraction of particulate matter (PM), especially PM10, concentrations are due to non-exhaust emissions, such as road abrasion and wear on tires and brake pads. Concentrating on road abrasion, we aimed to investigate blood coagulability in healthy adults after exposure to two types of stone materials commonly used in asphalt on Norwegian roads. This study followed a randomized, double-blind, cross-over study design. Using an exposure chamber, 24 healthy young volunteers were exposed to aggregates of two different types of rocks and placebo dust: quartz diorite, rhomb porphyry, and lactose (placebo dust). Each exposure session lasted for 4 hours (h), and blood samples were collected before exposure (baseline), 4 h post-exposure, and 24 h post-exposure to analyse potential changes in the von Willebrand factor (vWF) as well as of fibrinogen, d-dimer, leukocytes, and thrombocytes. The dust concentration in the exposure chamber was measured with real-time instruments and gravimetric samples of total dust, respirable dust, PM10, PM2.5, and ultrafine particles (UFP). The results were analysed using a linear mixed-effect model. Leukocyte blood counts increased post-exposure for all exposure materials; however, none of the increases were statistically significant. The concentration of fibrinogen increased after exposure to quartz diorite, while it decreased after exposures to rhomb porphyry and lactose. Type of material was a statistically significant explanatory variable for the concentration of fibrinogen, with the most significant increase occurring 24 h post-exposure to quartz diorite. After exposure to the three materials, vWF decreased. For the thrombocytes, an increase in blood count was observed 24 h post-exposure to quartz diorite and rhomb porphyry, with a modest (p = 0.09) positive association for quartz diorite. Although the results are limited, we conclude that the different effects observed post-exposure to quartz diorite support considering potential health effects when choosing materials in the production of asphalt.

Association Between Kidney Cancer and Occupational Exposure to Trichloroethylene.

OBJECTIVE: This study investigates the association between occupational exposure to trichloroethylene (TCE) and kidney cancer, as this correlation has been questioned. METHODS: The incidence of cancers was studied in a dynamic cohort of 997 male workers who for many years had been occupationally exposed to TCE. RESULTS: During a 50-year observation period, 13 cases of kidney cancer were observed (7.5 expected) with a standardized incidence ratio of 1.7 and a 95% confidence interval of 1.0 to 3.0. Four other cases, not included in the SIR analysis, were also observed. Long-term TCE exposure was positively confirmed for 14 of the 17 incident cases. There is reason to assume that the remaining cases also had been exposed to TCE. CONCLUSIONS: The present study supports the view that TCE is a kidney carcinogen.

Multi-element analysis of airborne particulate matter from different work tasks during subsea tunnel rehabilitation work.

Tunnel rehabilitation work involves exposure to various air contaminants, including airborne particulate matter (APM). Little is known on the contents of different chemical components of APM generated during tunnel work. The objective of the present study was to characterize exposure to APM and various elements for different job categories in different size fractions of APM during a subsea tunnel rehabilitation project carried out in Western Norway. Personal as well as stationary samples of inhalable, thoracic and respirable dust were collected from workers divided into 11 different job categories based on work operations performed, and air concentrations of a range of elements were determined using high-resolution inductively coupled plasma-mass spectrometry (HR-ICP-MS). Overall, APM concentrations were low, but with some measurements exceeding the American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) for inhalable particles, and considerable proportions of respirable and especially inhalable APM exceeding 10% of the TLVs. For most elements, air concentrations measured were quite low, in the ng/m(3) range, except for the major crustal elements Si, Fe, Al, and Mg, which were found to be in the µg/m(3) range. Asphalt millers overall had the highest exposure levels for APM and most measured elements; for instance, mean concentrations of V, Rb, and Mn were 380, 210, and 2000 ng/m(3) in inhalable and 33, 44, and 310 ng/m(3) in respirable APM. Mounting PVC membrane seemed to generate elevated levels of Cr, Zn, Sn, Pb, Sb, As, Mn, Fe, and Ni, whereas typical bedrock elements were elevated during drilling activities compared to the low exposed categories lead car drivers, foremen/surveyors, drivers of heavy-duty vehicles, and electricians. Overall, stationary samples contained lower amounts of dust and elemental constituents compared to personal samples. Elemental air concentrations were highly variable with occasional elevated values for APM and certain elements, particularly Cr and Zn.

Personal exposure to ultrafine particles from PVC welding and concrete work during tunnel rehabilitation.

OBJECTIVES: To investigate the exposure to number concentration of ultrafine particles and the size distribution in the breathing zone of workers during rehabilitation of a subsea tunnel. METHODS: Personal exposure was measured using a TSI 3091 Fast Mobility Particle Sizer (FMPS), measuring the number concentration of submicrometre particles (including ultrafine particles) and the particle size distribution in the size range 5.6-560 nm. The measurements were performed in the breathing zone of the operators by the use of a conductive silicone tubing. Working tasks studied were operation of the slipforming machine, operations related to finishing the verge, and welding the PVC membrane. In addition, background levels were measured. RESULTS: Arithmetic mean values of ultrafine particles were in the range 6.26×10(5)-3.34×10(6). Vertical PVC welding gave the highest exposure. Horizontal welding was the work task with the highest maximum peak exposure, 8.1×10(7) particles/cm(3). Background concentrations of 4.0×10(4)-3.1×10(5) were found in the tunnel. The mobility diameter at peak particle concentration varied between 10.8 nm during horizontal PVC welding and during breaks and 60.4 nm while finishing the verge. CONCLUSIONS: PVC welding in a vertical position resulted in very high exposure of the worker to ultrafine particles compared to other types of work tasks. In evaluations of worker exposure to ultrafine particles, it seems important to distinguish between personal samples taken in the breathing zone of the worker and more stationary work area measurements. There is a need for a portable particle-sizing instrument for measurements of ultrafine particles in working environments.

Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air.

INTRODUCTION AND OBJECTIVE: Swine confinement buildings are known to contain large concentrations of airway irritants, and a number of studies have shown acute inflammatory effects in previously unexposed subjects when introduced to the environment in such buildings. However, studies comparing different methods of assessing such reactions are lacking, and it is not known if a measurable response could be found at lower exposure rates. The purpose of this study was to investigate exposure levels in a Norwegian swine confinement building, the airway response to such exposure, and to compare invasive and non-invasive methods of response measurement. MATERIALS AND METHOD: Twelve medical students who were previously unexposed to swine dust stayed in a swine confinement building in Norway for 4 hours, and underwent measurements before and after the start of exposure. The same measurements were also performed beforehand, on the same weekday without exposure, in such a manner that the subjects were their own controls. RESULTS: The exposure assessment showed considerably lower concentrations of organic dust and endotoxin than earlier studies. However, small, but significant increases in markers of airway inflammation, were found. CONCLUSIONS: Airway response can be measured after lower exposure to airborne irritants in swine confinement buildings than previously known. Further research is needed to assess whether this finding can be utilized for preventive purposes.