[The effect of diabeton and metformin on the free-radical oxidation processes and the structural characteristics of the phospholipid composition of the erythrocyte membranes in non-insulin-dependent diabetes mellitus]. / Vliianie diabetona i metformina na protsessy svobodnoradikal'nogo okisleniia i strukturnye osobennosti fosfolipidnogo sostava éritrotsitarnykh membran pri insulinnezavisimom sakharnom diabete.

Newly detected noninsulin--dependent diabetes mellitus is shown to have changes in phospholipid structure of erythrocytic membranes: a fall in total phospholipids, sphingomyelin, phosphatidylcholine, phosphatidic acid, a trend to increasing lysophosphatidylcholine. The shifts go in parallel with lipid peroxidation activation. Carbohydrate metabolism compensation is not enough to eradicate the shifts. The process is also dependent on the properties of a sugar-reducing drug. Diabeton is recommended as beneficial in this respect, while metformin is efficient in combinations.

[The effect of insulin on the lipid composition of the erythrocyte membranes of diabetics]. / Vliianie insulina na lipidnyi sostav membrany éritrotsitov bol'nykh sakharnym diabetom.

A study is presented of the dynamics of components of lipid spectrum of erythrocytic membrane in insulin-dependent type of diabetes mellitus against the background of traditional types of treatment (Porcine insulin and insulin-zinc-suspension) and use of monospike and monocomponent insulins. Insulins of high purity were found to produce a normalizing effect on the disturbances of the lipid composition. Thus, cholesterol indices normalized in 2-3 months. The level of general phospholipids and dien conjugates improved as well. The changes were accompanied by positive changes in the fraction ratio of phospholipids while disorders of the fraction of phosphatidylcholine remained abnormal and low values phosphatidylinosite were registered.

[Spectrum of erythrocyte membrane lipids in various types of hypoglycemic therapy]. / Lipidnyi spektr éritrotsitarnoi membrany pri razlichnykh vidakh sakharosnizhaiushchei terapii.

Changes in the lipid spectrum of red cell membrane (cholesterol, total and fractional phospholipids) were examined in 46 patients with newly detected non-insulin-dependent diabetes mellitus at the period of the disease diagnosis and over the course of therapy with various sugar-reducing drugs. Diabeton, a gliclazide series drug, has shown the most manifest compensatory effect on red cell membrane lipid shifts. Diets and biguanide therapy for 6-8 months failed to stably normalize the detected shifts; further correction appeared to be necessary in such cases.