[Age-related characteristics of the activity of phagocytes in the normal state and in infections]. / Vozrastnye osobennosti aktivnosti fagotsitiruiushchikh leikotsitov v norme i pri infektsionnom protsesse.

Activity of peroxidase (AP) and maintenance of lysosomal cation proteins (CP) were studied during phagocytic reaction of polymorphonuclear leukocytes of healthy persons of different age and those with acute respiratory disease and chronic tonsillitis. It is found that during acute virus and chronic bacterial infection similar changes in AP and CP dynamics are observed, which is correlated with a decrease of phagocytic digesting function.

[Effects of acute respiratory viral infection on the state of cellular defense factors of the upper respiratory tract mucosa in young children]. / Vliianie ostroi respiratornoi virusnoi infektsii na sostoianie kletochnykh faktorov zashchity slizistykh obolochek verkhnikh dykhatel'nykh putei u detei rannego vozrasta.

Study of the qualitative and quantitative indicators of reprint smears from the surface of the upper respiratory mucosa in healthy infants and in these with acute respiratory viral infection has shown that migrating polymorphonuclear leukocytes take an active part in the functioning of the barrier of the upper respiratory mucosa at the early stages of human ontogenesis. The cytogram and cytochemical characterization of peprint smear cells from the upper respiratory mucosa in infants afflicted with acute respiratory viral infection are sensitive tests in the assessment of defence potentialities of the child's body.

[Participation of the proteolysis system in promoting the virulence of the influenza virus and development of the infectious process; the antiviral effect of protease inhibitors]. / Uchastie sistemy proteoliza v realizatsii virulentnosti virusa grippa i razvitii infektsionnogo protsessa; protivovirusnoe deistvie ingibitorov proteaz.

The results of the authors' own studies and data from the literature attesting to an important role of proteolytic mechanisms in influenza virus physiology and the development of the infectious process are summarized. The etiotropic and pathogenetic effectiveness of proteolysis inhibitors in influenza was demonstrated experimentally and clinically. Data are presented on the immunostimulating and prophylactic effect of a proteolysis inhibitor, E-aminocaproic acid. It is concluded that the use of proteolysis inhibitors in viral infections holds good promise.