[Multimodality treatment outcome of invasive thymomas]. / Rezultatele tratamentului multimodal în timoame.

UNLABELLED: The aim of the study was to analyze the progression of invasive thymomas associated with myasthenia gravis, after the resection and the progression of unresectable invasive thymomas with a combined chemoradiotherapy. The study was performed on two groups of patients: 8 patients with invasive thymomas and myasthenia gravis operated at the 3rd Surgical Clinic between 1986-1999; 4 patients with unresectable invasive thymomas treated at the Radiology-Oncology Clinic by combined chemoradiotherapy, between 1993-1998. The results are presented for each group of patients, separately. CONCLUSION: The best treatment of invasive thymomas is the multimodal one. The timing of each method was established based on the collaboration between surgeons, medical oncologists, radiotherapists and neurologists, depending on the characteristics of each patient.

[A practical study of the absorbed doses at the level of the organs at risk during the radiotherapy of bronchopulmonary cancer]. / Studiul practic al dozelor absorbite la nivelul organelor de risc, în cursul radioterapiei cancerului bronhopulmonar.

The radiotherapy of lung cancer with curative total doses (56-60 Gy), is limited by the presence of critical organs (esophagus, spinal cord). The use of computed TPS (Therapy Planning System) allows to the radiotherapist to calculate the values and to obtain dose distribution to the organs at risk, in the limit of biological tolerance levels. In our work, we present the calculation of the absorbed doses of Co60, at the spinal cord, at a patient with a cancer of the right lung, during irradiation.

[The psychosocial aspects of female patients with genital cancer]. / Aspecte psihosociale la bolnavele cu cancer genital.

Revealing a diagnosis as cancer, usually generates various emotional and psychosocial response in the patients: anxiety, negation of reality, passivity and generalized state of shock and anguish; long term projects and personal responsibilities are annihilated, the image of death grows enormously. Genital cancer women patients also exhibits sexual problems which can seriously complicate the psychic representation of disease and impair family life. Our study comprised 20 women patients who were hospitalized, with genital cancer diagnosis (ovarian cancer, neoplasms of the cervix and of the endometrium); by anamnesis and further discussions we tried to establish the main elements which generated different psychologic reactions. The perception of the reality of the diagnosis was proved to depend on age, personality type, doctor-patient and family-patient relationship. Each stage of disease and each treatment applied generates individual psychologic reaction which can be alleviated by communication between doctor and patients, by a patient adapted language. Complexity of psychological and sometimes psychic reactions of such patients requires that a psycho-oncologist be included in the complex oncologic treatment team; deeper knowledge of the problems and employment of individual or group therapy (the patient's family included) may lead to better psychic response to the malady.

[The antiemetic action of tropisetron (Navoban) in the cytostatic treatment of neoplastic diseases]. / Actiunea antiemetica a tropisetronului (Navoban) în tratamentul cu citostatice al afectiunilor neoplazice.

The most frequent side effects of chemotherapy are nausea and vomiting. This issue is a clinical analysis of the protective effect of a 5HT3 antagonist (Navoban-R; Sandoz Pharma Ltd., Basel, Switzerland) against chemotherapy--induced emesis (especially with the most emetic cytostatics--cisplatin and dacarbazine). In the first day of treatment, Navoban demonstrates a control of emesis for 75% of patients and in the following days for 80% of patients. The nausea is more frequent than vomiting. The most frequent side effects of Navoban were: headache (75% of patients), dizziness (62% of patients) and tiredness (50% of patients). This drug is a good protective against chemotherapy induce emesis and is very easy to administer.

[The use of hyperfractionated radiotherapy in soft-tissue sarcomas]. / Utilizarea radioterapiei hiperfractionate în sarcoamele de parti moi.

In classical irradiation, the local control can be negatively influenced by the accelerated clonogenic tumoral repopulation. A modality of control of this phenomenon can be accelerated hyperfractionated irradiation. The aim of this paper is the study of the effect of this type of irradiation in soft tissue sarcomas on patients of the Radiological-Oncological Clinic Iasi. Accelerated hyperfractionated irradiation causes a favorable response in the primary tumor with good local tolerance, but the "free of disease" period depends on the aim of irradiation (preoperative, postoperative or single therapeutical procedure).

[Radiotherapy concomitant with cisplatin chemotherapy in the treatment of cancer of the cervix uteri]. / Radioterapie concomitent cu chimioterapie cu cisplatin în tratamentul cancerului de col uterin.

Cancer of the cervix presents an increasing incidence and mortality in advanced stages. Failure of treatment consists in local recurrence, continuation of evolution or in distant metastasis. One of the strategies of improving the treatment response is the association of radiosensitization chemotherapy with irradiation. The aim of this paper is the study of the effect of cisplatin administration simultaneously with radiotherapy of primary cancer of the cervix and recurrences. This association has proved to be favourable as regards immediate and short period local control with an acceptable digestive and hematologic tolerance (gr. I-II).