Abnormal platelet aggregation measured by screen filtration pressure (sfp) in coronary heart disease: a new risk factor?

Platelet aggregate filtration pressure PAFP) has been measured in 38 male coronary heart disease patients (CHD) free from "risk factors" for the development of arteriosclerosis. Significantly (p less than 0.05) higher mean PAFP values (mmHg) were found in the CHD group as compared to the "control" group. Such finding suggests, though does not demonstrate, the "independent" role of platelet hyperaggregation in the development of CHD.

Cord blood cholesterol, triglycerides and lipoprotein electrophoresis in 124 Italian infants.

Total cholesterol (TC), triglycerides (TG), and lipoproteins (by electrophoresis on agarose gel) were determined in the cord blood of 124 Italian infants (Verona area). The mean TC and TG values, when compared with the values reported in other studies, turned out to be remarkably uniform, suggesting common genetic determinants in the modulation of blood lipids; no sex differences were observed. The TG distribution curve was skewed, overlapping the adult pattern. Cord blood TC and TG were not modified by the presence of perinatal factors. Both beta and alpha bands (on agarose gel electrophoresis) were present in all the cases. The pre-beta band was clearly detectable in 90% of the cases; it was barely visible for TG values below 20 mg/100 ml; occasionally a discrepancy between the intensity of the pre-beta band and the cord blood TG was observed, indicating a variable lipid composition of very low density lipoproteins (VLDL). In 4% of the cases a small band at the origin of the electrophoretic run was observed, consistent with the presence of chylomicrons. In the serum of both a newborn infant and its mother we detected a double band migrating in the pre-beta region. This finding confirms the hypothesis of a familial transmission of this abnormality.