RESUMO
A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.
Assuntos
Fosfatase Ácida/genética , Alelos , Mapeamento Cromossômico , Genética Populacional , Inglaterra , Eritrócitos/enzimologia , Humanos , Modelos Genéticos , Fenótipo , Polimorfismo GenéticoRESUMO
A method for determining plasma paroxonase activity using an auto-analyser is described. Frequency distributions for British and Indian subjects show bimodality. A study of 40 British families confirms the presence of a genetic polymorphism with regard to plasma paroxonase activity. Two phenotypes can be defined, controlled by two alleles at one autosomal locus. The frequency of the low activity phenotype is less in the Indian population than in the British population. Malay, Chinese, and African subjects fail to show obvious bimodality.
Assuntos
Hidrolases de Éster Carboxílico/sangue , Polimorfismo Genético , Grupos Raciais , Povo Asiático , Autoanálise , População Negra , Hidrolases de Éster Carboxílico/análise , Inglaterra , Feminino , Frequência do Gene , Humanos , Masculino , Fenótipo , População BrancaRESUMO
A study of forty patients with active lichen planus and a negative family history for diabetes showed that 42% had unequivocally abnormal oral glucose tolerance. The pattern of insulin response to glucose is similar to that seen in typical mild maturity-onset diabetes. There was no association between the presence of glucose intolerance and the duration or type of lesions. None of the patients with glucose intolerance had demonstrable islet-cell antibodies.
