[Results of a study of the reactogenicity and epidemiological effectiveness of a 2d revaccination against whooping cough]. / Rezul'taty izucheniia reaktogennosti i épidemiologicheskoi éffektivnosti II revaktsinatsii protiv kokliusha.

The reactogenicity and epidemiological effectiveness of the second revaccination against pertussis were studied in conformity with all the conditions of a controlled epidemiological trial. The character of the distribution of local and fever reactions in children aged 6 years after the second revaccination with adsorbed DTP vaccine suggests the presence of high sensitivity to the pertussis component of absorbed DTP vaccine in children of this age group. The results obtained from the study of epidemiological effectiveness (in 15,621 children) indicated that the second revaccination of children aged 6 years (at an interval of 3 or more years after the first revaccination) was not advisable as it did not influence noticeably the pertussis incidence.

[Correlation analysis of indices of toxin-neutralizing activity of sera and antibody titers in the passive hemagglutination reaction]. / Korreliatsionnyi analiz pokazatelei toksinneitralizuiushchei aktivnosti syvorotok i titrov antitel v reaktsii passivnoi gemaggliutinatsii

The authors compared the results of 20 experiments of titration of 1588 sera of children with different vaccination anamnesis by Jensen's method in the passive hemagglutination test with a stable erythrocytic diagnostic agent. In 18 of 20 experiments was established a mean and a high correlational association between the indices of antitoxic diphtheria immunity obtained by two methods. In macro- and micromodifications the passive hemagglutination test proved to be a highly effective method of rapid mass analysis and could be used in epidemiological studies.

[Regression analysis of the relation between antitoxic activity of sera (Jensen method) and antibody titers in the passive hemagglutination reaction]. / Regressionnyi analiz zavisimosti mezhdu antitoksicheskoi aktivnost'iu syvorotok (metod Iensena) i titrami antitel v reaktsii passivnoi gemaggliutinatsii (RPGA)

Antidiphtherial and antitetanus antitoxic immunity was determined in the sera of 1588 children (20 experiments) and 611 children and adults (12 experiments) by two methods--on animals and in the passive hemagglutination test (PHT). Factual data were grouped in accordance with a conditioned scale of the antitoxin values in IU composed of the values average for each interval. The series of two-fold dilutions represented a scale of titres of the same sera in the PHT. Mathematical analysis showed that there was a direct linear regressive relationship between the indices of antitoxic immunity obtained by different methods. As a rule, regression coefficients were below a unit, i. e. the rate of increase of the values by the HDT titre scale was somewhat retarded from the growth by the IU titre, this pointing to the difference in their value. The free member of the regression equation (a) characterizing this choice of the sera varied widely. Between the regression coefficients calculated for individual experiments statistically significant differences were revealed in almost 50% of cases. Transformation of quantitative indices of one test into quantitative characteristics obtained by the other method, with the aid of regression equation calculated outside the definite experiment, proved to be unfounded.