Infant skin maturation: Preliminary outcomes for color and biomechanical properties.

BACKGROUND: Newborn infant skin changes after birth but studies have focused on the epidermal barrier. Dermal properties are relevant for care, but literature on postnatal changes is sparse. We further characterized skin maturational changes in lightness, color and response to biomechanical stress. METHODS: Normal skin sites from subsets of participants in a trial on the progression and stage of infantile hemangiomas were retrospectively examined. Standardized photographs were analyzed as L*, a*, and b* images. Biomechanics were measured with the Cutometer® . RESULTS: Color changed significantly with increasing age. Skin was darker and redder at 2.0 vs. 5.4, 8.5 and 12.8 months. Yellow color increased, with higher values at 12.8 vs. 2.0, 3.5 and 5.4 months. Chest tissue was consistently more elastic than arm and face sites, with significantly higher elasticity for the youngest and oldest age groups. Biological elasticity, elastic recovery, and total recovery were significantly greater for the oldest subjects. Viscoelasticity and elastic deformation were lower at 5.5 vs. 8.8 and 17.6 months. Arm viscoelastic creep was highest at 2.8 months. CONCLUSION: Skin maturation continues into year two. Increasing elasticity and decreasing viscoelasticity may reflect increased collagen structure/function. The findings have implications for prevention of skin injury associated with mechanical forces.

Biomechanical properties of infantile hemangiomas: clinical stage and effect of age.

BACKGROUND: Infantile hemangiomas (IHs) are benign vascular neoplasms with rapid capillary proliferation shortly after birth and slow involution with diminishing capillary proliferative activity, fibrosis, and fatty replacement over 7-10 years. METHODS: Hemangiomas and contralateral control sites in 88 subjects were measured using a suction device, 6-mm probe and 200 mbar negative pressure. Mechanical properties were assessed vs. controls and effects of body site, depth, clinical stage, histology diagnosis, and time. RESULTS: Biological elasticity, overall elasticity, net elasticity, total recovery, and elastic recovery were lower for IH vs. controls (P < 0.001). IH total deformation, elastic deformation, viscoelastic creep, and residual deformation were higher than controls (P < 0.001). Involuting IHs had lower viscoelasticity than proliferating and stable lesions (P < 0.001) and lower viscoelastic creep than stable IHs (P = 0.04). IH viscoelasticity was higher at 2.3 than 12.9, 23.7, and 61.0 months and at 4.9 and 8.1 than 61.0 months. IH elastic recovery varied by body site with larger differences vs. control for abdomen and leg. Elastic recovery differences from control were smaller at younger vs. older ages. CONCLUSIONS: Measurement of biomechanical properties may be useful to characterize IH progression and treatment response in clinical settings.

Spatial and temporal variability in VOC levels within a commercial retail building.

UNLABELLED: A study was performed to characterize the concentration of dozens of volatile organic compounds (VOCs) at 10 locations within a single large building and track these concentrations over a 2-year period. The study was performed at a shopping center (strip mall) in New Jersey. A total of 130 indoor air samples were collected from 10 retail stores within the shopping center and analyzed for 60 VOCs by US EPA Method TO-15. Indoor concentrations of up to 55,100 microg/m(3) were measured for individual VOCs. The indoor/outdoor ratio (I/O) was as high as 1500 for acetone and exceeded 100 at times for various compounds, indicating that significant indoor air sources were present. A large degree of spatial variability was observed between stores within the building, with concentrations varying by three to four orders of magnitude for some compounds. The spatial variability was dependent on the proximity of the sampling locations to the indoor sources. A large degree of temporal variability also was observed for compounds emitted from indoor sources, but the temporal variability generally did not exceed two standard deviations (sigma). For compounds not emitted from indoor sources at significant rates, both the spatial and temporal variability tended to range within an order of magnitude at each location. PRACTICAL IMPLICATIONS: Many cross-sectional studies have been published where the levels of volatile organic compounds (VOCs) were measured in indoor air at one or two locations for houses or offices. This study provides longitudinal data for a commercial retail building and also addresses spatial variability within the building. The data suggest that spatial and temporal variability are important considerations for compounds emitted from indoor sources. Elevated concentrations were found in retail spaces with no apparent emission sources due to their proximity to other retail spaces with emission sources.

[Which factors modify drug-compliance?]. / Welche Faktoren beeinflussen die Medikamenten-Compliance?

Since the extent of medication noncompliance in schizophrenic patients ranges between 50 and 60%, evaluation of factors that are associated with noncompliance has become an important issue. 197 schizophrenic patients have been interviewed with regard to numerous issues: Form and type of medication; information about side effects; attitude of patients towards illness and medication. Our data suggest that information about benefits and side effects, as well as the attitude of patients towards illness and medication play an important role in the adherence to the treatment regimen.

The impact of familial loading on gender differences in age at onset of schizophrenia.

To evaluate the impact of familial loading and gender on age at onset, 197 schizophrenic patients were investigated. Patients with familial loading had an earlier age at onset without gender differences. In contrast, an earlier age at onset for men was found in sporadic cases. These data support that both gender and familial loading contribute to the heterogeneity of schizophrenia.

Cardiovascular and thermal responses of triathlon performance.

Triathletes typically train each triathlon event separately. Therefore, to determine the cardiovascular and thermal differences between training and triathlon performance, nine male triathletes performed a simulated 75-min (40 km) control bike and a 40-min (10 km) control run at 70% of maximal oxygen uptake. Control data were compared to data derived from a simulated triathlon (0.8-km swim, 75-min bike, and 40-min run). Results demonstrated that prior swimming significantly decreased (P less than 0.05) triathlon cycling work output (191 +/- 4.2 to 159 +/- 7.6 W) producing mean differences (P less than 0.05) in oxygen uptake (3.18 +/- 0.1 to 3.01 +/- 0.11.min-1), ventilation (84.7 +/- 4 to 80.4 +/- 4.21.min-1), stroke volume (128 +/- 7.1 to 118 +/- 3.5 ml.min-1), cardiac output (20.7 +/- 1.2 to 18.9 +/- 0.8 l.min-1), mean arterial pressure (105 +/- 3.8 to 96 +/- 7.9 mm Hg) and rectal temperature (38.2 +/- 0.2 to 38.4 +/- 0.3 degrees C). Triathlon running, while performing identical control work output, elicited significant increases (P less than 0.05) in oxygen uptake (3.41 +/- 0.1 to 3.85 +/- 0.1 l.min-1), ventilation (91.3 +/- 3.3 to 104.2 +/- 2.8 l.min-1), heart rate (161 +/- 3.1 to 174 +/- 3.6 beats.min-1), arteriovenous oxygen difference (15.3 +/- 0.2 to 17.2 +/- 0.3 ml.100 ml-1) and rectal temperature (38.3 +/- 0.2 and 39.2 +/- 0.3 degrees C) with significantly lower (P less than 0.05) stroke volume (138 +/- 2.4 to 129 +/- 3.6 ml.min-1) and mean arterial pressure (102 +/- 11.2 to 89 +/- 5.5 mm Hg).(ABSTRACT TRUNCATED AT 250 WORDS)