[Changes in lipid metabolism in patients with arteriosclerosis obliterans after charcoal hemoperfusion and hypolipidemic therapy in the preoperative period]. / Izmeneniia lipidnogo obmena u bol'nykh obliteriruiushchim atero- sklerozom pod vliianiem gemokarboperfuzii i gipolipidemicheskoi terapii pri provedenii predoperatsionnoi podgotovki.

The paper analyzes the results of the treatment of 26 patients with atherosclerosis obliterans of the lower extremities, which has been performed to make an intensive hypolipidemic preparation for an operation. The comprehensive approach based on the combination of medication (nicotinic acid, and its derivatives, cholestyramine, and SKH -2K charcoal hemoperfusion ) and efferent therapy reduced the plasma levels of total cholesterol by 27%, triglycerides to 48%, low density lipoprotein cholesterol to 40%, and increased high density lipoprotein cholesterol up to 72%. The similar course therapy may be repeatedly used in a follow-up of this group of patients.

[Preoperative preparation of patients with arteriosclerosis obliterans]. / Predoperatsionnaia podgotovka bol'nykh s obliteriruiushchim aterosklerozom.

The article analyses the immediate results of preoperative management and treatment of 13 patients with atherosclerosis obliterans of the lower limbs on the basis of drug hypolipidemic therapy and hemosorption on nonspecific sorbents of type CKH. Drug therapy comprised nicotinic acid, its derivatives in a daily dose of up to 2.5 mg, cholestiramine up to 20 g daily, vitamin therapy, and prodectin. Hemosorption was conducted on CKH-2K once in 4 days; 7 patients were given 5 perfusions each, 6 patients--7 perfusions each. Considerable clinical improvement occurred, hemodynamics improved, improvement of lipid metabolism was manifested by decrease of total cholesterol by 22%, triglycerides by 10%, and low density lipoproteins by 43% and increase of high density lipoproteins by 100%. The Cch atherogenicity coefficient decreased by 41%. The expediency of conducting no more than 4 sorptions was revealed and substantiated. Reconstructive vascular operations were performed on the patients. The postoperative period was uneventful. The late-term postoperative period was marked by progressive improvement of rheographic and biochemical values and stable normalization of lipid metabolism.