RESUMO
A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.
Assuntos
Amidoidrolases/antagonistas & inibidores , Hidrolases/antagonistas & inibidores , Inibidores de Proteases/síntese química , Inibidores de Proteases/farmacologia , Ácidos Sulfônicos/química , Amidoidrolases/metabolismo , Catálise , Ciclização , Hidrolases/metabolismo , Estrutura Molecular , Inibidores de Proteases/química , Ácidos Sulfônicos/síntese químicaRESUMO
[reaction: see text] An efficient intermolecular 1,3-dipolar cycloaddition of a variety of nitrones to pentafluorophenyl (PFP) vinylsulfonate is described. The transformation produces stable "reversed" cycloadducts of unprecedented stereo- and regioselectivity. Subsequent amine displacement of the PFP moiety furnished functionalized sulfonamide products in good yields.
Assuntos
Sulfonamidas/síntese química , Ácidos Sulfônicos/química , Compostos de Vinila/químicaRESUMO
[reaction: see text] Various radical species generated from either the corresponding iodo- or bromo- compounds and tri-n-butyltin hydride were added in an intermolecular fashion to the activated acceptor pentafluorophenyl vinylsulfonate. The products of each reaction were then subjected to aminolysis with a variety of different amines.