[Effect of ethanol on central mechanisms of alimentary and defensive motivation in the rabbit]. / Vliianie étanola na tsentral'nye mekhanizmy pishchevoi i oboronitel'noi motivatsii krolikov.

A single intravenous administration of ethanol (0.5 g/kg) to rabbits had different effects on the excitability of feeding and defensive motivational centers of the lateral and ventromedial hypothalamus. Ethanol abolished both inhibitory effects of the dorsal hippocampus and facilitatory action of the midbrain reticular formation on alimentary and defensive motivations. It elicited new power distributions of the main rhythms of general electrical cortical activity in the background and under stimulation of limbic-midbrain structures. Analysis of the activity of organello-specific enzymes in limbic-midbrain neurones revealed disturbances of cellular energetic processes caused by ethanol.

[Experimental study of the function and enzyme organization of pulmonary alveolar macrophages in peroral nitrosodimethylamine exposure]. / Eksperimental'noe izuchenie funktsional'nogo sostoianiia i fermentnoi organizatsii al'veoliarnykh makrofagov legkikh pri peroral'nom vozdeistvii nitrozodimetilamina.

The authors review the results of biochemical and cytological study of the function and enzymic structure of lung alveolar macrophages in the early stages of the development of the chemical carcinogen nitrosodimethylamine administered per os. The evidence obtained has shown that in the course of biological action of nitrosodimethylamine one can observe functional abnormalities of lung alveolar macrophages, accompanied by destabilization of the cell membrane and membranes of the subcellular organelles. This apparently reflects the manifestation of unfavourable action of the chemical carcinogen.

[Metabolism of sialocontaining glycoproteins and lysosomal enzyme activity and neurotropic effect of various environmental chemical factors]. / Obmen sialosoderzhashchikh glikoproteidov i aktivnost' fermentov lizosom pri neirotropnom éffekte nekotorykh khimicheskikh faktorov okruzhaiushchei sredy.

A comparative biochemical study of the sialocontaining glycoproteids metabolism and the activity of certain lysosome enzymes shows that the effect of different environmental, chemical factors (carbon disulphide, dimethyl acetamide, lead acetate; etc.) causes changes in the activity of certain lysosome enzymes and the enzyme-substrate system of N-acetyl neuraminic acid--N-acetyl neuraminic acid aldolase, participating, in the metabolism of sialocontaining glycoproteids as structural components of the brain biomembranes.

[Membrane-bound sialoglycoproteins of the rat liver as affected by the combined action of benz(a)pyrene and sulfur dioxide]. / Membranosviazannye sialoglikoproteidy pecheni krys pri sochetannom deistvii benz(a)pirena i sernistogo gaza.

Simultaneous effect of benz(a)pyrene and sulphurous gas was accompanied by distinct alteration in metabolism of sialoglycoproteins in liver tissue; at the time N-acetylneuraminic acid was redistributed in liver subcellular organelles (mitochondria, lysosomes and endoplasmic reticulum) as well as cytochromes P-450 and b5 were induced in liver microsomes. The alterations observed appear to play a definite role in manifestation of the unfavourable effect in combined action of the carcinogen and chemical contaminations of environments.

[Lysosomal and cytoplasmic enzymatic activity under the experimental action of carbon disulfide]. / Aktivnost' lizosomal'nykh i tsitoplazmaticheskikh fermentov pri éksperimental'nom deistvii serougleroda.

Activity of lysosomal enzymes and content of carbohydrate containing biopolymers (glycosaminoglycans, glycoproteins) were altered in various tissues (liver, kidney, brain, aorta) of experimental animals intoxicated with carbon disulfide. Possible role of the impairments observed, related to neurotropic and hepatotoxic effects, is discussed. Subsequent development of atherogenic and embryotoxic effects of carbon disulfide--one of contaminators of surroundings--are considered.

[Study of metabolic mechanisms of the isolated and combined effect of a chemical allergen]. / Issledovanie metabolicheskikh mekhanizmov izolirovannogo i sochetannogo deistviia khimicheskogo allergena.

Biochemical study of the activity of the enzyme systems of different localization in the cell connected with the subcellular structures - lysosomes (hyaluronidase, N-acetyl-beta-D-glucosaminidase, beta-glucosidase) and hyaloplasm-soluble (aldolase of neuraminic acid), and also a study of the state of the enzyme-substrate groups, belonging to the immunoreactive biopolymeres containing a carbohydrate (glucoproteins, glycosaminoglycanes) was carried out in the tissues of different organs (the liver, kidneys, small intestine, skin) and in the blood serum of albino rats exposed to the isolated and joint (in combination with various doses of ultraviolet irradiation) action of the chemical allergen (dinitrochlorbenzene). General and specific regularities of metabolic reactions, the appearance of which could presumably be connected with the development of delayed allergy were revealed.