Integrated Ultrasound and Photoacoustic-Guided Laser Ablation Theranostic Endoscopic System.

Advancements in ablation techniques have paved the way towards the development of safer and more effective clinical procedures for treating various maladies such as atrial fibrillation (AF). AF is characterized by rapid, chaotic atrial activation and is commonly treated using radiofrequency applicators or laser ablation catheters. However, the lack of thermal lesion formation and temperature monitoring capabilities in these devices prevents them from measuring the treatment outcome directly. In addition, poor differentiation between healthy and ablated tissues leads to incomplete ablation, which reduces safety and causes complications in patients. Hence, a novel photoacoustic (PA)-guided laser ablation theranostic device was developed around a traditional phased-array endoscope. The proposed technology provides lesion formation, tissue distinguishing, and temperature monitoring capabilities. Our results have validated the lesion monitoring capability of the proposed technology through PA correlation maps. The tissue distinguishing capability of the theranostic device was verified by the measurable differences in the PA signal between pre-and post-ablated mice myocardial tissue. The increase in the PA signal with temperature variations caused by the ablation laser confirmed the ability of the proposed device to provide temperature feedback.

Síndrome inflamatorio multisistémico en niños asociado a infección por SARS-CoV-2 / Multisystemic inflammatory syndrome in children associated with SARS-CoV-2 infection

El siguiente reporte de caso describe la presentación del síndrome inflamatorio multisistémico asociado a la infección por el coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2 por sus siglas en inglés) en niños, que inicialmente se comparó con el síndrome mucocutáneo linfonodular, mejor conocido como enfermedad de Kawasaki clásica. Sin embargo, existen marcadas diferencias entre ambos síndromes, como se observará en el desarrollo del caso clínico, el cual cursa con un importante compromiso pulmonar, desarrollando un síndrome de distress respiratorio agudo pediátrico y posteriormente secuelas cardiovasculares que determinan el desenlace desfavorable. En este caso, la paciente desarrolló las manifestaciones de gravedad al sexto día de enfermedad y se inició cuidados intensivos oportunos con soporte aminérgico, ventilación con maniobras de protección alveolar e inicio temprano de inmunoglobulinas, lo que permitió el destete progresivo de todas las medidas instauradas. Así como se obtuvieron aciertos en el manejo intensivo, otros aspectos de la terapéutica se van dejando de lado con el mayor conocimiento de esta entidad y su reconocimiento temprano

The following case report describes the presentation of the multisystemic inflammatory syndrome associated with infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children, which was initially compared with lymphonodular mucocutaneous syndrome, better known as classic Kawasaki disease. However, there are marked differences between both syndromes, as will be observed in the development of the clinical case, which presents with significant pulmonary involvement, developing a pediatric acute respiratory distress syndrome and later cardiovascular sequelae that determine the unfavorable outcome. In this case, the patient developed the manifestations of severity on the sixth day of the disease and timely intensive care with aminergic support, ventilation with alveolar protection maneuvers and early initiation of immunoglobulins was started, which allowed progressive weaning of all the measures established. As well as successes were obtained in the intensive management, other aspects of the therapy are being put aside with the greater knowledge of this entity and its early recognition

Biofabrication of spheroids fusion-based tumor models: computational simulation of glucose effects.

In vitrotumor models consisting of cell spheroids are increasingly used for mechanistic studies and pharmacological testing. However, unless vascularized, the availability of nutrients such as glucose to deeper layers of multicellular aggregates is limited. In addition, recent developments in cells-only biofabrication (e.g. 'scaffold-free bioprinting'), allow the creation of more complex spheroid-based structures, further exposing the cells to nutrient deprivation within these constructs. To explore the impact of glucose availability on such tumor-like structures, we used the CompuCell3D platform for modeling of tumor spheroids. By monitoring the types of cells, fusing pairs geometry and the distance between spheroids centers of mass, we made novel heuristic observations on how binary- and multi-spheroid fusions are impacted by glucose availability. At limiting glucose concentrations mimicking hypoglycemia we noted an abrupt collapse of the tumor spheroids, unexpectedly amplified by the contact with normal cell spheroids. At higher glucose concentrations, we found an increased intermixing of cancerous cells, strong anti-phase oscillations between proliferating and quiescent tumor cells and a structural instability of fusing tumor spheroids, leading to their re-fragmentation. In a model of tumor microenvironment composed of normal cell spheroids fusing around a tumoral one, the competition for glucose lead to either the tumor's disappearance, to a steady state, or to its expansion. Moreover, the invasion of this microenvironment by individual tumor cells was also strongly depended on the available glucose. In conclusion, we demonstrate the value of computational simulations for anticipating the properties of biofabricated tumor models, and in generating testable hypotheses regarding the relationship between cancer, nutrition and diabetes.

Síndrome de Burnout y la psiconeuroendocrinoinmunología: consecuencias en el personal de salud durante la pandemia por Coronavirus / Burnout syndrome and psycho neuro endocrino immunology: consequences in health workers during the Coronavirus pandemic / Síndrome de burnout e psiconeuroendocrinoimmunologia: consequências em profissionais de saúde durante a pandemia de Coronavírus

Sr. Editor. Hasta la fecha se han documentado 7,439,220 de contagio por coronavirus (COVID-19) con una cifra de muertes de 961,400, de los cuales aproximadamente 7,000 hacen parte del personal de salud. En Colombia, las cifras por COVID-19 llegan a 758,398 con una mortalidad de 3,1%, lo que equivale a 24,039 muertes. Esto ha significado una gran carga mental para el personal de salud, conduciendo a un incremento en el número de suicidios por parte de este personal. Colombia no es ajena a la situación, tiene un reporte de 43,157 casos de los cuales 7,651 se dieron en médicos, 11,171 en auxiliares de enfermería, 4,611 en enfermeras profesionales. En cuanto a la mortalidad, hasta la fecha de revisión del 3 de febrero del 2021 había una cifra de 216 fallecidos de los cuales 71 eran médicos, 38 eran auxiliares de enfermería y trece enfermeras profesionales (1). DOI: https://doi.org/10.29375/01237047.3997

Until today, 7,439,220 infections have been documented by coronavirus (COVID-19) with a death toll of 961,400, of which approximately 7,000 make part of the health personnel. In Colombia, the figures for COVID-19 reaches 758,398 with a mortality of 3.1%, which is equivalent to 24,039 deaths. This has meant a great mental burden for health personnel, driving an increase in the number of suicides by this staff. Colombia is no stranger to the situation, it has a report from 43,157 cases of which 7,651 occurred in physicians, 11,171 in nursing assistants, 4,611 in nurses Professionals. Regarding mortality, to date revision of February 3, 2021 there was a figure of 216 deceased of which 71 were doctors, 38 were nursing assistants and thirteen professional nurses (1). DOI: https://doi.org/10.29375/01237047.3997

Até hoje, 7.439.220 infecções foram documentadas por coronavírus (COVID-19) com um número de mortes de 961.400, das quais aproximadamente 7.000 fazem parte do pessoal de saúde. Na Colômbia, os dados do COVID-19 chegam a 758.398 com mortalidade de 3,1%, o que equivale a 24.039 óbitos. Isso tem significado uma grande carga mental para o pessoal de saúde, levando a um aumento no número de suicídios dessa equipe. A Colômbia conhece bem a situação, tem um relatório de 43.157 casos, dos quais 7.651 ocorreram em médicos, 11.171 em auxiliares de enfermagem, 4.611 em profissionais de enfermagem. Em relação à mortalidade, até a data da revisão de 3 de fevereiro de 2021 havia 216 mortos, sendo 71 médicos, 38 auxiliares de enfermagem e treze profissionais de enfermagem (1). DOI: https://doi.org/10.29375/01237047.3997

Perfil epidemiológico bucal en un asentamiento de población desplazada y destechada (Antioquia-Colombia) / Oral epidemiological profile of a violently displaced and homeless community in Bello, Colombia

Introducción y Objetivo: El desplazamiento forzado por violencia y la situación de pobreza que vive el país exige que se realicen propuestas en poblaciones específicas que tengan en cuenta grupos vulnerables en aspectos importantes como la salud bucal. El propósito fué analizar la situación desalud bucal de la población desplazada y destechada ubicada en el asentamiento “Altos de Oriente”, del municipio de Bello, por medio de evaluación clínica teniendo en cuenta los principales datos sociodemográficos. Materiales y Métodos: Se realizó un estudio carácter descriptivo, exploratorio, acerca del perfil epidemiológico bucal en un asentamiento de pobladores desplazados y destechados del municipio de Bello (Antioquia- Colombia) en el año 2006. La muestra fueron 58 personas captadas voluntariamente en una jornada de salud. Se tuvieron en cuenta variables sociales y demográficas, el nivel de higiene bucal, el estado dental, periodontal y protésico. Resultados: Se encontró alta historia y prevalencia de caries dental y de enfermedades orales en comparación con la población general colombiana, con algunas diferencias por sexo; así mismo, los resultados informan de un acceso deficiente a los servicios de salud, en especial de salud bucal. Conclusiones: Se analizó la situación de salud bucal en el contexto social y político actual del país así como las repercusiones en la calidad de vida, producto del fenómeno de desplazamiento forzado por la violencia y sus expresiones como la pobreza, la marginalidad y la exclusión social. Estos hallazgos evidencian la necesidad de profundizar en la problemática de poblaciones específicas, para la construcción de propuestas que mejoren las oportunidades de acceso a servicios sociales y a servicios de salud bucal.

Introduction and Objetives: Purposes are required in specific groups in important aspects such as oral health concerned with the forced displacement by violence and the poverty situation in Colombia. The purpose of this study was evaluate the oral health situation of a homeless community violently displaced by force, living in the “Altos de Oriente” Shelter Camp in the city of Bello, Colombia by means of a clinical evaluation which took into account the main socio-demographic variables. Materials and Methods: A descriptive and exploratory study was carried out in order to assess theoral epidemiological profile of said community during 2006. The sample consisted of 58 subjects who volunteered during a health brigade. The study analyzed social and demographic variables, the level of oral health as well as dental, periodontal and restorative conditions. Results: An increased history and prevalence of caries and oral diseases was found in comparison with the general Colombian population with some differences between genders. Results also indicated deficient access to health services in general and especially to those related to oral health. Conclusions: The oral health situation of the displaced community was analyzed under the current social and political context ofthe country as well as their repercussions in the quality of life, product of the forced displacement phenomena and its expressions such as poverty, marginality and social exclusion. These findings evidence the need to study more deeply the problems of specific populations, in order to design proposals that will improve opportunities to access social and oral health services.