Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Inorg Chem ; 62(4): 1362-1376, 2023 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-36490364

RESUMO

Radioisotopes of Cu, such as 64Cu and 67Cu, are alluring targets for imaging (e.g., positron emission tomography, PET) and radiotherapeutic applications. Cyclen-based macrocyclic polyaminocarboxylates are one of the most frequently examined bifunctional chelators in vitro and in vivo, including the FDA-approved 64Cu radiopharmaceutical, Cu(DOTATATE) (Detectnet); however, connections between the structure of plausible reactive intermediates and their stability under physiologically relevant conditions remain to be established. In this study, we share the synthesis of a cyclen-based, N,N-alkylated spirocyclic chelate, H2DO3AC4H8, which serves as a model for N-protonation. Our combined experimental (in vitro and in vivo) and computational studies unravel complex pH-dependent speciation and enable side-by-side comparison of N- and O-protonated species of relevant 64Cu radiopharmaceuticals. Our studies suggest that N-protonated species are not inherently unstable species under physiological conditions and demonstrate the potential of N,N-alkylation as a tool for the rational design of future radiopharmaceuticals.


Assuntos
Ciclamos , Compostos Radiofarmacêuticos/química , Radioisótopos de Cobre/química , Distribuição Tecidual , Tomografia por Emissão de Pósitrons/métodos , Quelantes/química , Alquilação
2.
J Phys Chem B ; 126(45): 9417-9423, 2022 11 17.
Artigo em Inglês | MEDLINE | ID: mdl-36331532

RESUMO

The C-H and O-H oscillators on the surfaces of thin films of human-derived skin oil and squalene are probed under ambient conditions (300 K, 1 atm total pressure, 40% RH) using second-order vibrational spectroscopy and contact angle goniometry before and after exposure to ppb amounts of ozone. Skin oil and squalene are found to produce different vibrational sum frequency generation spectra in the C-H stretching region, while exposure to ozone results in surface spectra for both materials that is consistent with a loss of C-H oscillators. The measured contact angles show that the hydrophobicity of the films increases following exposure to ozone, consistent with the reduction in C═C···H2O ("πH") bonding interactions that is expected from C═C double bond loss due to ozonolysis and indicating that the polar functional groups formed point toward the films' interiors. Implications for heterogeneous indoor chemistry are discussed.


Assuntos
Poluição do Ar em Ambientes Fechados , Ozônio , Humanos , Esqualeno/química , Poluição do Ar em Ambientes Fechados/análise , Ozônio/análise , Ozônio/química , Pele/química , Interações Hidrofóbicas e Hidrofílicas
3.
J Phys Chem B ; 125(15): 3932-3941, 2021 04 22.
Artigo em Inglês | MEDLINE | ID: mdl-33835820

RESUMO

Human skin oils are significant scavengers of atmospheric oxidants in occupied indoor environments, and squalene is a major ozone-active constituent. Here, we present a combined spectroscopic and atomistic modeling approach to elucidate the conformational and orientational preferences of squalene at the air/oil interface and their implications for reactions with ozone. We find that squalene chains have a tendency to align with the surface normal, resulting in different concentrations of the various types of its double bonds and thus different reactivities. We also observe the presence of water at the surface of this hydrophobic compound. Both findings have possible implications for the design and outcomes of kinetic models describing this important aspect of indoor air chemistry.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...