RESUMO
Effects of enalapril on congestive heart failure and survival until 12 months have been evaluated in 60 patients with congestive heart failure (II, III, IV NYHA class) versus 60 control patients. Enalapril has been administered with digitalis and diuretic for 12 months 5 mg twice a day; in 60 control patients only digitalis and diuretic have been administered. Patients have been controlled every month during 12 months evaluating: NYHA class, time of exercise at treadmill, ejection time of left ventricle, speed index of ejection, cardiac output, systolic output, ECG, blood pressure, creatinine, BUN and electrolytes. After 12 months a significant increase (p less than 0.001) of systolic and cardiac output in patients with enalapril has been recorded. Also the increase of exercise time was more evident in patients with enalapril (p less than 0.01). The results show that long term treatment with enalapril in patients with congestive heart failure, improving cardiac performance, gives an hemodynamic and symptomatic benefit.
Assuntos
Enalapril/uso terapêutico , Insuficiência Cardíaca/tratamento farmacológico , Adulto , Idoso , Feminino , Seguimentos , Insuficiência Cardíaca/fisiopatologia , Humanos , Assistência de Longa Duração , Masculino , Pessoa de Meia-IdadeAssuntos
Arritmias Cardíacas/terapia , Infarto do Miocárdio/complicações , Adulto , Idoso , Arritmias Cardíacas/complicações , Terapia por Estimulação Elétrica , Ventrículos do Coração , Humanos , Masculino , Pessoa de Meia-Idade , Marca-Passo Artificial , Taquicardia/complicações , Taquicardia/terapiaAssuntos
Ajmalina/farmacologia , Glicosídeos Digitálicos/farmacologia , Sistema de Condução Cardíaco/efeitos dos fármacos , Propranolol/farmacologia , Verapamil/farmacologia , Adulto , Idoso , Bloqueio de Ramo/fisiopatologia , Eletrocardiografia , Sistema de Condução Cardíaco/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome de Wolff-Parkinson-White/fisiopatologiaRESUMO
Radioimmunologically determined digoxin and beta methyl digoxin values were the same in cardiopaths with and without clinical and instrumental changes referable to chronic cirrhosis or hepatitis. Lower values, however, were noted when gastroenteric disturbances were present. This was especially true of beta methyl digoxin in subjects with hyperkinetic-hyperchlorhydric syndromes due to depressed gastric pH, with a consequent inhibition of beta methyl digoxin absorption, presumably caused by lability of the molecule as a result of methylation of the terminal digitoxose group.
