[The function of the hypophyseal-thyroid system in chronic opisthorchiasis and its combination with the Salmonella typhi carrier state]. / Sostoianie gipofizarno-tireoidnoi sistemy pri khronicheskom opistorkhoze i ego sochetanii s nositel'stvom Salmonella typhi.

The hormonal function of the hypophysis and thyroid (TTG, T3, T4) and its dependence on hepatobiliary function, examined by hepatobiliscintigraphy, were studied by radioimmunoassay in 71 patients with chronic opisthorchiasis and in 18 chronic carriers of Salmonella typhi. in both groups. The decrease of T3 and T4 in the presence of normal TTG level was found. The imbalance of thyroid hormones activity is likely to be associated with hepatobiliary dysfunction. In chronic opisthorchiasis the hormonal disturbance may be one of the factors favouring the S. typhi carriership.

[The effect of the anthelmintics biltricide and chloxyl on the level of cellular and humoral immunity in patients with chronic opisthorchiasis]. / Vliianie antigel'mintikov bil'tritsida i khloksila na uroven' kletochnogo i gumoral'nogo immuniteta u bol'nykh khronicheskim opistorkhozom.

The effect of two anthelmintics--biltricide and chloxyl--on the immune status has been compared in patients with chronic opisthorchiasis. It has been established that in using chloxyl there is a more marked and persistent imbalance of immunoregulatory T-lymphocyte subpopulations (T mu-helpers-inducers and T gamma-suppressors-effectors).

[The effect of specific treatment on the function of the small intestine in opisthorchiasis]. / Vliianie spetsificheskogo lecheniia na funktsional'noe sostoianie tonkoi kishki pri opistorkhoze.

The anthelminthic agents chloxylum and prasiquantel were examined for their effects in patients with an above 5-year history of Opisthorchis invasion. The van de Kamer procedure revealed that chloxylum produced an inhibitory effect on absorption of d-xylose and fat. Prasiquantel failed to impair the absorptive function of the small intestine. Helminthological curing in patients with chronic opisthorchiasis was not shown to normalize dysfunction of the small intestine.

[The effect of various factors on the immune status of patients with chronic opisthorchiasis. 2. Changes in immunologic indices in patients with chronic opisthorchiasis undergoing chloxyl treatment for various lengths of time]. / Vliianie razlichnykh faktorov na immunnyi status bol'nykh khronicheskim opistorkhozom. Soobshchenie 2. Izmeneniia immunologicheskikh pokazatelei u bol'nykh khronicheskim opistorkhozom s razlichnoi kratnost'iu lecheniia khloksilom.

Most immunological characteristics became practically normal 7-9 months after a single chloxyl treatment course in patients with chronic cholecystocholangitic opisthorchiasis. The patients who required repeated chemotherapy showed more profound and steady immune disturbances.

[The structure of immunoregulatory cells as a reflection of their interaction in infectious diseases]. / Struktura immunoreguliatornykh kletok kak otrazhenie ikh vzaimodeistviia pri infektsionnykh zabolevaniiakh.

Analysis of the structure of immunoregulatory cells (IRC) as the reflection of cell interaction in healthy persons and in patients with typhoid fever, tick-borne encephalitis, or chronic opisthorchiasis has shown that the characteristics under study (information entropy, structural information, the coefficient of ecological-genetic correspondence) are highly sensitive and specific, which makes it possible to use them quite effectively for differentiating health from disease and for identifying this disease. The study of IRC structure as the reflection of cell interrelations helps evaluate the changes in the organization of IRC system as a whole in different infectious diseases.

[Cellular and humoral immunity and nonspecific resistance factors in chronic opisthorchiasis patients during dispensary observation]. / Sostoianie kletochnogo i gumoral'nogo immuniteta i nekotorykh faktorov nespetsificheskoi rezistentnosti u bol'nykh khronicheskim opistorkhozom v periode dispansernogo nabliudeniia.

In 116 patients with opisthorchiasis running a cholecystocholangitic variant of the disease course, the characteristics of nonspecific resistance (complement, lysozyme, properdin), cell-mediated and humoral immunity (T- and B-lymphocytes, T gamma-, T mu-, O-, D-, A-cells and auto-rosette-forming cells, IgG, IgA and IgM) have been studied. Essential changes in these characteristics before and after treatment, as well as at the remote periods of dispensary observation, have been established.

[Functional information model of the normal immune status and in pathology]. / Informatsionno-funktsional'naia model' immunnogo statusa v norme i pri patologii.

The informative logical analysis has been used as the basis for the construction of the functional models of the immune status in the form of logical formulae. In these models the character of interrelations between immunocompetent cells in health and disease is reflected. Such models make it possible to substantiate the necessity, as well as the differentiated methods, of the correction of disturbances in the immune status, depending on the nature of the pathological case.