Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 10 de 10
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Artigo em Inglês | MEDLINE | ID: mdl-36901025

RESUMO

The COVID-19 disease has infected many countries, causing generalized impacts on different income categories. We carried out a survey among households (n = 412) representing different income groups in Nigeria. We used validated food insecurity experience and socio-psychologic tools. Data obtained were analyzed using descriptive and inferential statistics. The earning capacities of the respondents ranged from 145 USD/month for low-income earners to 1945 USD/month for high-income earners. A total of 173 households (42%) ran out of food during the COVID-19 pandemic. All categories of households experienced increasing dependency on the general public and a perception of increasing insecurity, with the high-income earners experiencing the greatest shift. In addition, increasing levels of anger and irritation were experienced among all categories. Of the socio-demographic variables, only gender, educational level of the household head, work hours per day, and family income based on society class were associated (p < 0.05) with food security and hunger due to the COVID-19 pandemic. Although psychological stress was observed to be greater in the low-income earning group, household heads with medium and high family income were more likely to have satisfactory experiences regarding food security and hunger. It is recommended that socio-economic groups should be mapped and support systems should target each group to provide the needed support in terms of health, social, economic, and mental wellness.


Assuntos
COVID-19 , Humanos , Fatores Socioeconômicos , Nigéria , Pandemias , Abastecimento de Alimentos , Segurança Alimentar , Estresse Psicológico
2.
Alex J Vet Sci ; 70(1): 14-24, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37180492

RESUMO

Coronavirus Disease 2019 (COVID-19), a viral pneumonia-like disease caused by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) started in Wuhan, Hubei Province of China on December 31st 2019, and assumed a pandemic status; infecting about 30 million people, with a mortality in excess of 957,000 as at 20st September, 2020. This study assessed the knowledge, attitude, and practices concerning COVID-19 among veterinarians with a view to detecting variables that may hinder their effective contributions towards the management and control of COVID-19 outbreak in Nigeria.The study found that male veterinarians had significantly good knowledge (p=0.012, OR=0.157, CI=0.03-0.66) and attitude (OR=18.415, CI=1.45-5.16, P=0.011) towards COVID-19 than female counterparts. Similar results were also recorded regarding practices (OR=2.941, CI=1.03-8.36, P=0.043). Educational qualification was found to be significantly associated with attitude of veterinarians in respect of COVID-19 prevention (OR=0.473, CI=0.073-0.011, P=0.006). Thus, gender (male) was found to be independent predictors of good knowledge, attitude and practices regarding COVID-19. In addition, educational qualification was also found to be an independent predictor of attitude of veterinarians regarding COVID-19 control. Veterinarians generally had good knowledge about the epidemiology, diagnosis, treatment and prevention of COVID-19. However, despite their knowledge, the level of willingness of veterinarians to support national response activities was still poor. This study advocated for a collaborative efforts (one-health) between medics and vets in tackling future pandemics/infectious diseases like COVID-19. In addition, since most vet knows the basics of infectious diseases like COVID-19, they can be deployed for national response activities.

3.
Appl Environ Microbiol ; 84(21)2018 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-30171000

RESUMO

One hundred seventy-eight mycoplasma strains isolated from South African poultry flocks between 2003 and 2015 were identified by full-genome sequencing and phylogenetic analysis of the 16S rRNA gene and were classified as follows: Mycoplasma gallisepticum (25%), M. gallinarum (25%), M. gallinaceum, (23%), M. pullorum (14%), M. synoviae (10%), and M. iners (3%), as well as one Acheoplasma laidlawii strain (1%). MIC testing was performed on the axenic samples, and numerous strains of each species were resistant to either chlortetracycline or tylosin or both, with variable sensitivity to enrofloxacin. The strains of all species tested remained sensitive to tiamulin, except for one M. gallinaceum sample that demonstrated intermediate sensitivity. The mutation of A to G at position 2059 (A2059G) in the 23S rRNA gene, which is associated with macrolide resistance, was found in the South African M. gallisepticum and M. synoviae strains, as well as a clear correlation between macrolide resistance in M. gallinarum and M. gallinaceum and mutations G354A and G748A in the L4 ribosomal protein and 23S rRNA gene, respectively. No correlation between resistance and point mutations in the genes studied could be found for M. pullorum Only a few strains were resistant to enrofloxacin, apart from one M. synoviae strain with point mutation D420N, which has been associated with quinolone resistance, and no other known markers for quinolone resistance were found in this study. Proportionally more antimicrobial-resistant strains were detected in M. gallinaceum, M. gallinarum, and M. pullorum than in M. gallisepticum and M. synoviae Of concern, three M. gallinaceum strains showed multidrug resistance to chlortetracycline, tylosin, and oxytetracycline.IMPORTANCE Nonpathogenic poultry Mycoplasma species are often overlooked due to their lesser impact on poultry health and production compared to the OIE-listed pathogenic strains M. gallisepticum and M. synoviae The use of antimicrobials as in-feed growth promoters and for the control of mycoplasmosis is common in poultry production across the world. Here, we provide evidence that certain nonpathogenic Mycoplasma species are acquiring multidrug resistance traits. This would have significant implications if these species, for which no vaccines are applied, are able to transfer their antibiotic resistance genes to other mycoplasmas and bacteria that may enter the human food chain.


Assuntos
Antibacterianos/farmacologia , Farmacorresistência Bacteriana Múltipla , Infecções por Mycoplasma/veterinária , Mycoplasma/efeitos dos fármacos , Mycoplasma/isolamento & purificação , Doenças das Aves Domésticas/microbiologia , Animais , Galinhas , Clortetraciclina/farmacologia , Diterpenos/farmacologia , Testes de Sensibilidade Microbiana , Mycoplasma/classificação , Mycoplasma/genética , Infecções por Mycoplasma/microbiologia , Filogenia , África do Sul , Tilosina/farmacologia
4.
Avian Dis ; 62(1): 50-56, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29620458

RESUMO

Mycoplasma gallinaceum is not among the most pathogenic mycoplasmas affecting poultry, but its continuous re-isolation from flocks in South Africa displaying typical signs of mycoplasmosis prompted us to revisit its role in respiratory disease. Specific-pathogen-free white leghorn chickens were co-challenged with either M. gallinaceum (MGC) and QX-like infectious bronchitis virus (IBV), or the more virulent Mycoplasm gallisepticum (MG) and IBV. No clinical signs were observed apart from sneezing in chickens challenged with IBV, MGC + IBV, and MG + IBV. On postmortem examination, one bird each in the MGC + IBV and IBV groups developed peritonitis or airsacculitis, respectively. In the tracheas, the MG + IBV group showed the most severe ciliary damage with a mean ciliostatic score of 32.40 compared to scores of 26.83 and 20.4 for the MGC + IBV and IBV groups, respectively. Corresponding tracheal lesions were recorded. Quantitation of the challenge pathogens by quantitative real-time PCR and real-time reverse transcriptase-PCR determined that MGC was shed in much higher titers from the trachea than MG, when co-infected with IBV. Interestingly, the presence of both MG and MGC appeared to enhance IBV replication in the tracheas of infected chickens, whereas the presence of IBV suppressed MG and MGC proliferation in the trachea. In general, the nonpathogenicity of M. gallinaceum in chickens was confirmed, but it was able to aggravate respiratory disease and pathogen proliferation with virulent QX-like IBV.


Assuntos
Galinhas , Infecções por Coronavirus/veterinária , Vírus da Bronquite Infecciosa/fisiologia , Infecções por Mycoplasma/veterinária , Mycoplasma gallisepticum/fisiologia , Mycoplasma gallisepticum/patogenicidade , Doenças das Aves Domésticas/microbiologia , Animais , Coinfecção/microbiologia , Coinfecção/veterinária , Coinfecção/virologia , Infecções por Coronavirus/virologia , Infecções por Mycoplasma/microbiologia , Doenças das Aves Domésticas/virologia , Reação em Cadeia da Polimerase em Tempo Real/veterinária , África do Sul , Organismos Livres de Patógenos Específicos , Virulência
5.
Avian Pathol ; 47(3): 261-270, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29451010

RESUMO

Mycoplasma gallisepticum (MG) is the primary cause of chronic respiratory disease in poultry. We investigated the protective efficacy of the live-attenuated ts-11 and 6/85 MG vaccines against a local MG strain and, in order to enhance signs and mimic a typical field situation, we co-infected birds with a virulent strain of QX-like infectious bronchitis virus (IBV). Both vaccines showed similar ability to protect infected chickens from clinical signs, although ts-11 performed slightly better. Despite the lower protection against clinical disease, 6/85-vaccinated birds had significantly (P ≤ 0.05) lower tracheal lesion scores and mucosal thickness at day 28 post-vaccination (7 days post-challenge [dpc] with MG, 2 dpc IBV) and day 31 post-vaccination (10 dpc MG challenge, 5 dpc IBV) compared to ts-11 vaccinated birds, but these difference was not significant at day 33 (12 dpc MG, 7 dpc IBV). Pathogen infection and replication was assessed by qPCR, and the 6/85 vaccine produced a more significant (P ≤ 0.05) reduction in MG replication in the lungs, kidneys and livers but enhanced late replication in bursae and caecal tonsils. In contrast, the ts-11 vaccine had a more pronounced reductive effect on replication in tracheas, air sacs, bursae and heart at days 28 and 31, yet increased replication in lungs. Interestingly, both vaccines provided non-specific protection against IBV challenge. The co-challenge model provided useful data on vaccine efficacy, especially on days 31 and 33, and tracheas, lungs, air sacs, kidneys, liver and caecal tonsils were the best organs to assess.


Assuntos
Vacinas Bacterianas/imunologia , Galinhas/imunologia , Vírus da Bronquite Infecciosa/imunologia , Infecções por Mycoplasma/veterinária , Mycoplasma gallisepticum/imunologia , Doenças das Aves Domésticas/prevenção & controle , Sacos Aéreos/microbiologia , Animais , Coinfecção/veterinária , Infecções por Mycoplasma/microbiologia , Infecções por Mycoplasma/prevenção & controle , Doenças das Aves Domésticas/microbiologia , Doenças das Aves Domésticas/virologia , Organismos Livres de Patógenos Específicos , Vacinação/veterinária
6.
Onderstepoort J Vet Res ; 83(1): 1035, 2016 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-26974177

RESUMO

Peste des petits ruminants, caused by the peste des petits ruminants virus (PPRV), is a highly contagious and economically important transboundary viral disease of domestic and wild small ruminants and a major hindrance to small-ruminant production in Nigeria. The seroprevalence and distribution of PPRV antibodies in small ruminants in rural households, farms, live animal markets and slaughter slabs across the six different agro-ecological zones of Nigeria were determined. A total of 4548 serum samples from 3489 goats and 1059 sheep were collected in 12 states. A PPRV competitive enzyme-linked immunosorbent assay was used to test the samples and the data analysed with R statistical software version 3.0.1. The study animals included all ages and both sexes. The overall prevalence estimate of sera positive for PPRV antibodies was 23.16% (n = 1018 positive samples per 4548 total samples, 95% confidence interval: 21.79% - 24.57%). There were significant differences in the seroprevalence between the states (p = 0.001). Taraba State had the highest seroprevalence of 29.51%, whilst the lowest seroprevalence of 14.52% was observed in Cross River State. There were no significant differences in the PPRV seroprevalence between male and female animals (p = 0.571), age (p = 0.323) and between species (p = 0.639). These data indicate the current seroprevalence to PPRV in the small-ruminant population in Nigeria.


Assuntos
Doenças das Cabras/epidemiologia , Peste dos Pequenos Ruminantes/epidemiologia , Vírus da Peste dos Pequenos Ruminantes/isolamento & purificação , Doenças dos Ovinos/epidemiologia , Matadouros , Criação de Animais Domésticos , Animais , Anticorpos Antivirais , Ensaio de Imunoadsorção Enzimática/veterinária , Feminino , Doenças das Cabras/virologia , Cabras , Masculino , Nigéria/epidemiologia , Peste dos Pequenos Ruminantes/virologia , Prevalência , Estudos Soroepidemiológicos , Ovinos , Doenças dos Ovinos/virologia
7.
J S Afr Vet Assoc ; 86(1): e1-e4, 2015 04 30.
Artigo em Inglês | MEDLINE | ID: mdl-26016787

RESUMO

A flightless wild juvenile rock pigeon (Columba guinea) with pox-like lesions was picked up on the premises of the Faculty of Veterinary Science, University of Pretoria, Onderstepoort. The pigeon was housed overnight for possible treatment the following day but died before any other intervention could be instituted. At necropsy, coalescing masses of yellowish nodular cutaneous tumour-like lesions principally on the featherless areas were noticed on the dead pigeon's head as well as the beak. Histological examination of the sampled skin lesions revealed multifocal areas of hypertrophic and hyperplastic epidermal epithelial cells with eosinophilic intracytoplasmic inclusion bodies (Bollinger bodies). Extract from the lesion was processed and inoculated on the chorioallantoic membranes (CAM) of 11-day-old embryonated chicken eggs and this produced pocks on one of the CAM at day 7 post-inoculation. Electron microscopy confirmed the presence of poxvirus in the CAM with the pock lesions.


Assuntos
Avipoxvirus/isolamento & purificação , Doenças das Aves/patologia , Columbidae , Infecções por Poxviridae/veterinária , Animais , Doenças das Aves/virologia , Infecções por Poxviridae/patologia , Infecções por Poxviridae/virologia , África do Sul
8.
Onderstepoort J Vet Res ; 82(1): 986, 2015 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-26842367

RESUMO

Escherichia coli is usually a benign commensal of the gut microflora. However, when E. coli acquires virulence genes it can multiply rapidly and cause disease through colonisation of the intestinal mucosa. Escherichia coli can become a significant pathogen in young pigs. We report an investigation of fatal colisepticaemia in weanling pigs from emerging farms where piglets and weaners were diarrhoeic and the mortality rate ranged between 15% and 70% in each litter. Faecal and tissue samples were processed for histopathology, bacteriology and molecular biology (multiplex and monoplex polymerase chain reaction) and we recovered enteroaggregative multidrug-resistant E. coli producing EAST-1 enterotoxin. An association between poor housing conditions and the observed cases was established and future management programmes were recommended to reduce the impact of such pathogens. Enteroaggregative E. coli is becoming a major problem in the pig industry. It therefore becomes necessary to establish the full impact of E. coli on the South African pig industry and to determine the geographic extent of the problem.


Assuntos
Antibacterianos/farmacologia , Farmacorresistência Bacteriana Múltipla , Infecções por Escherichia coli/veterinária , Escherichia coli/efeitos dos fármacos , Sepse/veterinária , Doenças dos Suínos/mortalidade , Animais , Infecções por Escherichia coli/microbiologia , Infecções por Escherichia coli/mortalidade , Fezes/microbiologia , Feminino , Reação em Cadeia da Polimerase/veterinária , Sepse/microbiologia , Sepse/mortalidade , África do Sul/epidemiologia , Suínos , Doenças dos Suínos/microbiologia , Desmame
9.
J Infect Dev Ctries ; 9(12): 1298-307, 2015 Dec 30.
Artigo em Inglês | MEDLINE | ID: mdl-26719935

RESUMO

INTRODUCTION: Since the first case of Ebola virus disease (EVD) in Guinea in 2013, major outbreaks have been reported in West Africa. METHODOLOGY: Cases and fatalities of EVD caused by Zaire Ebola virus (ZEBOV) were evaluated, and the risks of dying in the general population and in healthcare workers were assessed. RESULTS: The case fatality rate estimated for EVD was 76.4% in 20 studies. Cumulative proportion of fatal cases in West Africa was 42.9%, 30.1%, and 64.2% in Liberia, Sierra Leone, and Guinea, respectively. The proportion of total deaths in Liberia, Sierra Leone, and Guinea was 42.5%, 35.8%, and 21.6%, respectively. Healthcare workers were at higher risk of dying compared with the general public, and the same applied to intense transmission countries and to countries with sufficient bed capacities. The declaration of a health emergency "out-of-control" situation by the World Health Organization on 8 August 2014 reduced the risk of death among patients. Factors including deplorable healthcare delivery infrastructure in war-ravaged regions of Africa, the impotence of governments to enforce public health regulations, and the loss of confidence in public healthcare delivery programs were key among others factors that enhanced the spread and magnitude of outbreaks. CONCLUSIONS: The findings underscore the need for an overall re-appraisal of the healthcare systems in African countries and the ability to cope with widespread epidemic challenges. Outbreaks like that of Ebola diseases should be handled not just as a medical emergency but also a socio-economic problem with significant negative economic impacts.


Assuntos
Doença pelo Vírus Ebola/epidemiologia , Doença pelo Vírus Ebola/mortalidade , Mortalidade , África Ocidental/epidemiologia , Feminino , Humanos , Masculino , Administração em Saúde Pública/métodos , Medição de Risco
10.
Res Vet Sci ; 93(1): 520-8, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21774952

RESUMO

The control of Newcastle disease (ND) in South Africa has proved difficult since 2002 following the introduction of lineage 5d/VIId Newcastle disease virus (NDV) strain ("goose paramyxovirus" - GPMV) to which commercially available ND vaccines appeared less effective. Most of the ND infections, even in fully vaccinated hens were characterized consistently by a drop in egg production. In this study, commercial and SPF hens-in-lay were vaccinated with La Sota vaccine and challenged with a GPMV isolate. Immunohistochemical labeling was used to determine the distribution of viral antigen in the oviduct of the hens. Following reports that cloacal vaccination offered better protection against egg production losses than the oro-nasal route, the efficacy of cloacal and ocular routes of vaccination against challenge were compared. Results showed that La Sota vaccine offered birds 100% protection against the virulent ND (GPMV) virus challenge from clinical disease and death, but not against infection and replication of the GPMV, as birds showed varying degrees of macropathology. Histopathology of the oviduct of infected birds revealed multifocal lymphocytic inflammation in the interstitium as well as mild glandular ectasia and mild edema. Finely granular NDV-specific immunolabeling was demonstrated in the cytoplasm of epithelial cells and mononuclear (lymphohistiocytic) cells in the interstitium of the oviduct. Both vaccine and virulent GPMV showed greatest tropism for the uterus (versus the magnum and isthmus). There was no clear difference in the protection of the oviduct and in the distribution of oviductal GPMV antigens between the two routes of vaccination.


Assuntos
Antígenos Virais/análise , Doença de Newcastle/prevenção & controle , Vírus da Doença de Newcastle , Oviductos/virologia , Vacinas Virais/uso terapêutico , Animais , Galinhas/virologia , Ensaio de Imunoadsorção Enzimática/veterinária , Feminino , Doença de Newcastle/imunologia , Doença de Newcastle/patologia , Doença de Newcastle/virologia , Vírus da Doença de Newcastle/imunologia , Oviductos/química , Oviductos/patologia , Vacinas Virais/administração & dosagem , Vacinas Virais/imunologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...