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1.
Klin Lab Diagn ; 63(4): 233-238, 2018.
Artigo em Russo | MEDLINE | ID: mdl-30677279

RESUMO

The purpose of study is to investigate significance of detection of number of CD45-positive thrombocytes and ratio neutrophils/lymphocytes in evaluation of risk of development of re-stenosis after implantation of drug-eluting stents in patients with chronic ischemic heart disease and diabetes mellitus type II. The examination was applied to 126 patients with chronic forms of ischemic heart disease who passed through repeat coronary angiography during first year after implantation of drug-eluting stents. The patients were separated on two groups depending on availability of diabetes mellitus type II. In both groups, the patients passed through comparing of angiography and clinical characteristics. Also, a logistic model was developed prognosticating development of re-stenosis. The re-stenosis developed more often in patients with diabetes mellitus type II (54.5%) than in patients without diabetes mellitus type II (32.4%; p=0.01). The comparative analysis of more than 35 characteristics permitted to establish risk factors of development of re-stenosis with the highest prognosticating capacity among patients with diabetes mellitus type II. These risk factors were CD45-positive thrombocytes and ratio neutrophils/lymphocytes. To prognosticate development of re-stenosis a logistic regression model was developed comprising number of circulating CD45-positive thrombocytes, ratio neutrophils/lymphocytes and availability of diabetes mellitus type II. The model demonstrated high prognosticating value as regards development of re-stenosis: OR = 15.1 (95% CI 4.81-31, p < 0.001). The square under ROC-curve: AUC = 0.83 (95% CI 0,72-0,92; р < 0,001). The increasing of number of circulating CD45-positive thrombocytes and ratio neutrophils/lymphocytes can be considered as a valuable risk factors of development of re-stenosis in case of diabetes mellitus type II.


Assuntos
Plaquetas/citologia , Reestenose Coronária/sangue , Diabetes Mellitus Tipo 2/complicações , Linfócitos/citologia , Isquemia Miocárdica/complicações , Neutrófilos/citologia , Constrição Patológica , Angiografia Coronária , Diabetes Mellitus Tipo 2/sangue , Stents Farmacológicos , Humanos , Antígenos Comuns de Leucócito , Isquemia Miocárdica/sangue , Fatores de Risco , Resultado do Tratamento
2.
Bull Exp Biol Med ; 162(4): 524-527, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28243907

RESUMO

The study was carried out in 126 patients with stable angina pectoris, who underwent elective coronary artery stenting with drug-eluting stents and follow-up angiography within 6-12 months thereafter. Five significant risk factors of restenosis were identified by binary comparisons of different variables. The logistic regression equation that included the level of CD45-positive platelets, diabetes, small vessel stenting, number of simultaneously implanted stents in one patient, and lesion length demonstrates the highest level of prediction of in-stent restenosis (OR=22.8; p<0.001). ROC-analysis demonstrated high prognostic value of the logit model (area under ROC curve 0.87, p<0.001). The data suggest that a close relationship exists between the development of restenosis and the level of circulating CD45+ platelets.


Assuntos
Angina Pectoris/patologia , Plaquetas/patologia , Constrição Patológica/patologia , Doença das Coronárias/patologia , Stents Farmacológicos/efeitos adversos , Adulto , Idoso , Angina Pectoris/metabolismo , Angina Pectoris/cirurgia , Plaquetas/metabolismo , Constrição Patológica/diagnóstico por imagem , Constrição Patológica/etiologia , Angiografia Coronária , Doença das Coronárias/metabolismo , Doença das Coronárias/cirurgia , Vasos Coronários/metabolismo , Vasos Coronários/patologia , Vasos Coronários/cirurgia , Diabetes Mellitus/fisiopatologia , Feminino , Expressão Gênica , Humanos , Antígenos Comuns de Leucócito/genética , Antígenos Comuns de Leucócito/metabolismo , Masculino , Pessoa de Meia-Idade , Curva ROC , Fatores de Risco
3.
Kardiologiia ; 56(4): 5-10, 2016 Apr.
Artigo em Russo | MEDLINE | ID: mdl-28294852

RESUMO

The purpose of research - the study of the level of soluble receptor for advanced glycation end products (CNG) in patients with coronary heart disease (CHD) with angina pectoris who have emerged restenosis after implantation of drug-eluting stents.


Assuntos
Reestenose Coronária/sangue , Stents Farmacológicos , Isquemia Miocárdica , Receptor para Produtos Finais de Glicação Avançada/sangue , Angina Pectoris , Angiografia Coronária , Feminino , Produtos Finais de Glicação Avançada/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/sangue , Isquemia Miocárdica/terapia
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