[A method of determining middle molecules]. / Sposob opredeleniia "srednikh molekul".

The authors suggest a method for the detection of 'medium molecules' to be used for rapid diagnosis of poisoning. They present their arguments in favor of a higher specificity of this method as against other rapid methods for 'medium molecule' detection in biologic fluids of the body. The authors' data evidence a high correlation between the results of the suggested method and gel filtration technique. The procedure may be used for the rapid diagnosis of peptidemia severity in the patients with grave endogenic intoxication and in cases when endotoxicosis is not the underlying condition.

[Middle molecules--formation and methods of determination]. / "Srednye molekuly"--obrazovanie i sposoby opredeleniia.

Medium molecules have been detected by two methods, gel filtration and screening technique, in patients with diffuse purulent peritonitis and with chronic renal insufficiency. No close correlation between the findings of the two methods has been observed. The results lead to a conclusion that, despite being rapid and simple, the screening method is hardly adequate for cases with endogenous intoxication. Approaches to improvement of this method are discussed.