Air pollution and comorbidity burden influencing acute hospital mortality outcomes in a large academic teaching hospital in Dublin, Ireland: a semi-ecologic analysis.

OBJECTIVE: To investigate the extent to which air pollution interacts with comorbidity in determining mortality outcomes of emergency medical admissions. STUDY DESIGN: Routinely collected data were used to study all emergency medical admissions to an academic teaching hospital in Dublin, Ireland, from 2002 to 2018. Air pollution was measured by particulate matter with aerodynamic diameter ≤10 µm (PM10) and sulphur dioxide (SO2) levels on the day of admission. Comorbidity Score was measured using a previously derived score. METHODS: A multivariable logistic regression model was used to relate air pollutant levels, Comorbidity Scores, and their interaction to 30-day in-hospital mortality. RESULTS: There were 102,483 admissions in 58,127 patients over 17 years. Both air pollutant levels and Comorbidity Score were associated with 30-day in-hospital mortality. On admission days with PM10 levels above the median, mortality was higher (Odds ratio [OR] 1.09; 95% confidence interval [CI] 1.06, 1.18) at 11.2% (95% CI 10.5, 12) compared with 10.4% (95% CI 10, 10.7) on days when PM10 levels were below the median. On admission days with SO2 levels above the median, mortality was higher (OR 1.13; 95% CI 1.10, 1.16) at 12.2% (95% CI 11.4, 13) compared with 10.7% (95% CI 10.3, 11.1) on days when SO2 levels were below the median. Comorbidity Score was strongly associated with mortality (mortality rate of 8.9% for those with a 6-point score vs mortality rate of 30.3% for those with a 16-point score). There was limited interaction between air pollutant levels and Comorbidity Score. CONCLUSION: Both air pollution levels on the day of admission and Comorbidity Score were associated with 30-day in-hospital mortality. However, there was limited interaction between these two factors.

Pilot evaluation of an online weight management programme.

This intervention examined the efficacy of a six-week online weight loss programme. Students and staff of a third level institution (n=183) were recruited to the programme which provided individualised dietary advice for weight loss. Eighty-five participants (mean age 29.7 years, mean BMI 28.9kg/m2, 33% male) met the minimum inclusion criterion of logging on to the study website at least twice. All participants who completed the full six-week programme lost weight (n=31), with significant reductions in mean weight (2.8kg), BMI (0.9kg/m2) and waist circumference (4.1cm) observed between the start and end of the programme (all P<0.001). Among "completers", males lost more weight than females (4.2kg vs. 1.9kg, P=0.004). One in four completers lost >5% of their bodyweight, with reductions in biscuit and alcohol consumption being most predictive of weight loss. These findings suggest that individualised online dietary advice is effective in achieving short-term weight loss, especially in males.

Symptoms of stress and depression effect percentage of body fat and insulin resistance in healthy youth: LOOK longitudinal study.

OBJECTIVE: This study examined the longitudinal and cross-sectional effects of both psychosocial stress and depressive symptoms on insulin resistance and percentage body fat in a cohort of healthy Australian children, following them from childhood into adolescence. METHOD: Participants were 791 healthy, initially Grade 2 children (7-8 years; 394 girls), selected from the general community. Psychosocial stress was assessed using the Children's Stress Questionnaire, while depressive symptoms were assessed using the Children's Depression Inventory. Fasting blood samples for serum insulin and plasma glucose were collected to calculate the homeostasis model assessment-insulin resistance (HOMA-IR). Other measurements were height, weight, percentage body fat (dual energy x-ray absorptiometry), physical activity (pedometers), and pubertal maturation (Tanner score). RESULTS: Boys who reported more symptoms of depression had higher insulin resistance, irrespective of adiposity (p = .016); and longitudinally, we found a trend for boys who developed more depressive symptoms to develop higher insulin resistance (p = .073). These findings did not extend to girls. Furthermore, boys and girls with higher depressive symptoms had a higher percentage of body fat (p = .011 and .020, respectively); and longitudinally, boys whose depressive symptoms increased became fatter (p = .046). CONCLUSION: Our data provide evidence that early symptoms of depression increase insulin resistance, independent of adiposity. Our evidence that early symptoms of depression may lead to overweight, and obesity provides further reason to suggest that early attention to children with depression, even in preclinical stages, may reduce risk of chronic disease in later life. (PsycINFO Database Record

Radiology imaging delays as independent predictors of length of hospital stay for emergency medical admissions.

AIM: To investigate the extent to which the time to completion for computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound could be shown to influence the length of stay and costs incurred while in hospital, while accounting for patient acuity. MATERIALS AND METHODS: All emergency admissions, totalling 25,326 imaging investigations between 2010-2014 were evaluated. The 50(th), 75(th), and 90(th) centiles of completion times for each imaging type was entered into a multivariable truncated Poisson regression model predicting the length of hospital stay. Estimates of risk (odds or incidence rate ratios [IRRs]) of the regressors were adjusted for acute illness severity, Charlson comorbidity index, chronic disabling disease score, and sepsis status. Quantile regression analysis was used to examine the impact of imaging on total hospital costs. RESULTS: For all imaging examinations, longer hospital lengths of stay were shown to be related to delays in imaging time. Increased delays in CT and MRI were shown to be associated with increased hospital episode costs, while ultrasound did not independently predict increased hospital costs. The magnitude of the effect of imaging delays on episode costs were equivalent to some measures of illness severity. CONCLUSION: CT, MRI, and ultrasound are undertaken in patients with differing clinical complexity; however, even with adjustment for complexity, the time delay in a more expeditious radiological service could potentially shorten the hospital episode and reduce costs.

Psychological distress leads to reduced physical activity and fitness in children: the Australian longitudinal LOOK study.

Stress and depression can affect an individual's level of physical activity and fitness, which may place them at risk of developing cardiovascular disease. This study investigates the longitudinal effects of stress and depression on physical activity and cardiorespiratory fitness among youth. Six hundred and seventy-six children, initially aged 8 years, from the LOOK study completed a modified version of the Children's Depression Inventory, the Children's Stress Questionnaire, and objective physical activity and cardiorespiratory fitness assessments on three occasions, every 4 years. Depressive symptoms had a direct effect (longitudinal) on the cardiorespiratory fitness of girls, with a similar trend for boys. In cross-sectional analyses, a child who identified with more symptoms of depression and stress was likely to be less fit and less physically active, which in girls extended to less moderate-to-vigorous physical activity. Our findings, that both physical activity and fitness are impacted by depression and stress may contribute to strategies directed towards achieving enhanced physical activity and reductions in obesity.

Improved outcomes of high-risk emergency medical admissions cared for by experienced physicians.

BACKGROUND: Physician experience has been shown to improve clinical outcomes. Limited numbers of experienced clinicians make it unfeasible that they would care for all patients. We hypothesized that physician experience would impact outcomes for patients with high, but not low, risk of mortality. METHODS: All emergency admissions from 2002 to 2013 were studied. Two groups at low and high risk for mortality (1.3% (95% CI: 1.13, 1.62) vs. 19.4% (95% CI: 18.5, 20.3)) were defined by a risk prediction method comprising acute Illness Severity Score, Charlson Comorbidity Index and sepsis status. Length of stay (LOS) and 30-day in-hospital mortality were the primary end points. Consultant experience was studied univariately and also entered into a multiple logistic regression model to predict 30-day in-hospital survival. A zero-truncated Poisson regression model assessed LOS and incidence rate ratios (IRR) were calculated. RESULTS: Over the 12-year study period 66 933 admissions were recorded in 36 271 patients. High-risk patients cared for by more experienced (≥20 years qualified) physicians had a lower 30-day in-hospital mortality (19.4 vs. 17.1% P < 0.001), relative risk reduction 11.9%. The multivariable odds ratio of a 30-day in-hospital death for an experienced physician was 0.89 (95% CI: 0.82, 0.97; P = 0.009). LOS was shorter for high-risk patients allocated to experienced physicians with a multivariable IRR of 0.77 (95% CI: 0.94, 0.99; P = 0.02). No difference in outcomes was found for low-risk patients. CONCLUSION: High-risk but not low-risk patients have improved outcomes when cared for by physicians with greater experience.

Dietary contributors to hypertension in adults reviewed.

Recent national surveys which measured respondents' blood pressure (BP) levels have shown a high prevalence of hypertension amongst the Irish population, with approximately two-thirds of men and over half of women aged 45 years and over affected. Higher prevalence rates are observed with advancing age. Established diet- and lifestyle-related risk factors for hypertension such as high salt intake, high alcohol consumption and physical inactivity are pervasive in Ireland and are believed to contribute significantly to the high national prevalence of this condition. Additional dietary deficits have been implicated in the development of hypertension, however, including low fruit and vegetable intake, low dairy food consumption and low intake of oily fish. Deficiencies of single micro-nutrients such as folate, riboflavin, vitamin C and vitamin D have also been recently recognised as risk factors for hypertension. For each of these factors, there is evidence that the food and nutrient intakes of many Irish adults fall short of the ideal. These dietary and nutritional deficits, when superimposed on Ireland's existing health-subversive behaviours and escalating rates of obesity, constitute a potent constellation of risk factors for hypertension. However, they also represent viable and potentially effective targets for health promotion initiatives. This review aims to describe the main nutritional, dietary and lifestyle contributors to hypertension in Ireland with a view to informing future interventions aimed at alleviating Ireland's burden of hypertensive disease.

Benefits of early development of eye-hand coordination: evidence from the LOOK longitudinal study.

We investigated longitudinal and cross-sectional relationships between eye-hand coordination (EHC) and cardiorespiratory fitness (multistage run), physical activity (pedometers), percent body fat (%BF, dual energy x-ray absorptiometry), body image, and organized sport participation (questionnaires) in 406 boys and 384 girls at 8 and 10 years of age. EHC was measured by a throw and wall-rebound catch test involving 40 attempts of increasing difficulty. Median EHC improved during two years from 18 to 32 (boys) and 9 to 24 (girls), and gender differences and improvements were both significant (P < 0.001). Cross-sectional analyses showed that boys and girls with better EHC were fitter (P < 0.001), and a longitudinal relationship showed that girls who improved their EHC over the two years became fitter (P < 0.001). There was also evidence that children with better EHC possessed a more positive body image (P = 0.05 for combined sex data), but there was no evidence of any relationships between EHC and %BF or PA (both P > 0.3). Finally, even at age 8 years, boys and girls participating in organized sport possessed better EHC than non-participants. These data provide evidence for the premise that early acquisition of this single motor skill promotes the development of a child's fitness, body image, and participation in sport.

Modelling change in adolescent smoking behaviour: stability of predictors across analytic models.

OBJECTIVES: The current paper examined the variability of predictors of changes in adolescent smoking across linear and nonlinear analytic models. DESIGN: Three analytic models typically used to model adolescent smoking behaviour were tested: one linear model of change (standard linear), one static linear model (pre-post linear) and one nonlinear model of change (cusp catastrophe). Variability in model composition was assessed by examining the pattern of variables achieving statistical significance and proportion of variance explained. METHODS: Model testing was conducted on data from Australian adolescents successfully tracked through a 12-month longitudinal study of smoking (N = 779). The survey measured demographics, self-reported smoking, smoking among friends and family, self-esteem, neuroticism, coping, stress and risk taking. RESULTS: The results indicated that while predictors of change were invariant across analytic models explanatory power varied markedly. Models of change in smoking that included simple, interacted or polynomial forms of initial conditions (past behaviour) explained more than four times the variance of models without. CONCLUSIONS: These results justified confidence in the predictors of change in adolescent smoking across analytic models. A secondary implication was that more research into past behaviour's role in the context of dynamical models of adolescent smoking and other health behaviour is needed.

Profiles of adolescent stress: the development of the adolescent stress questionnaire (ASQ).

The importance of stress in the understanding of adolescent health and well-being is widely documented. The measurement of adolescent stress has however been subjected to sufficient methodological and conceptual criticism in recent times to warrant a concerted re-evaluation of the exercise. This study sought information on the nature of adolescent stressors, building on a previous instrument developed by the first author to ask adolescents themselves to inform the development of a pool of new items reflecting stressor experience and to advise on the wording of these items to comprehensively assess that experience. This pool of items was then administered as a self-reported questionnaire to a large sample of school-age adolescents (N>1000) together with a scale to assess the intensity of distress arising from stressor occurrence. Principal components analysis of the questionnaire yielded 10 internally reliable dimensions of adolescent stress, the nature of which were consistent with the available literature on adolescent stressor experience. Scales constructed from this PCA related positively to measures of anxiety and depression, and negatively to a measure of self-esteem, suggesting that they were valid measures of adolescent stress. Test-retest reliability was good for all scales. The resultant Adolescent Stress Questionnaire (ASQ) is therefore suggested to have potential for the measurement of adolescent stress in both research and clinical contexts.

A cusp catastrophe model analysis of changes in adolescent substance use: assessment of behavioural intention as a bifurcation variable.

Behavioural intention was advanced as an alternative bifurcation variable to peer pressure in the context of a cusp catastrophe model of changes in adolescent substance use (Clair, 1998; Byrne, Mazanov & Gregson, 2001). Three sets of models were tested using data from a 12 month longitudinal study of adolescent smoking in Australia: the first with peer pressure only as the bifurcation term, the second with behavioural intention only and the third with both. In isolation both bifurcation variables performed similarly (adjusted-R2 and beta). In the third model, peer pressure edged out behavioural intention as an indicator of catastrophic change. Post hoc analysis revealed the polynomial and simple terms of initial conditions were more important than the bifurcation variable to explain change in smoking behaviour. This provoked a call for more work on finding an appropriately complex (non-straight line), theoretically justifiable mathematical model of adolescent substance use. Overall, behavioural intention was considered equivalent to peer pressure as a bifurcation variable although further research is needed to confirm this result.

Adolescent stress and future smoking behaviour: a prospective investigation.

OBJECTIVE: Adolescent stress has been retrospectively associated with various measures of smoking behaviour in school-aged samples. The present study sought to extend this to a prospective investigation in order to examine the possibly formative influences of stress on the onset of smoking in adolescents. METHOD: A 12-month follow-up study related sources and degree of adolescent stress measured at study commencement with the onset of smoking behaviour 12 months later in a large cohort of adolescents attending Australian secondary schools. RESULTS: Adolescent stress was only weakly related to smoking onset in adolescent males and even this could possibly be explained by other factors. In adolescent girls, however, prospective associations were stronger and more broadly represented across the various domains of adolescent stress, suggesting that stress may exert a formative influence on smoking onset for girls. CONCLUSION: Management strategies for adolescent stress may be an affective target for smoking prevention programs among adolescent girls.

A comparison of predictors of the adolescent intention to smoke with adolescent current smoking using discriminant function analysis.

OBJECTIVES: This paper explores one possible operationalization of smoking intention to assist development of adolescent smoking intervention programmes. Such programmes usually focus on predictors of current smoking, ignoring predictors of intentions to smoke, or how intentions relate to actual future smoking. DESIGN AND METHODS: Respondents took part in two stages of a repeated measures national survey on Australian adolescent smoking behaviour (12-month interval between administrations). A total of N=1419 adolescents provided matched data, measuring personal smoking habits, intentions of smoking behaviour, stress (seven subscales), self-esteem and response to the General Health Questionnaire (GHQ-12). RESULTS: A comparison of discriminant function predictors showed similarity between the current smoking and intention to smoke, with only one predictor differing between the functions. Non-smokers were more behaviourally consistent with their stated non-smoking intention over 12 months (i.e. remain non-smokers) than smokers (i.e. intention seemed unrelated to actual behaviour). CONCLUSIONS: While the predictors give no general indication of whether the processes behind the intention to smoke differ from current smoking, the intention to smoke may be a better focus for intervention with smokers given the apparent inconsistency with stated intention. Intervention for non-smokers may be usefully focused on maintaining non-smoking rather than preventing smoking.

PRO_LIGAND: an approach to de novo molecular design. 6. Flexible fitting in the design of peptides.

This paper describes the further development of the functionality of our in-house de novo design program, PRO_LIGAND. In particular, attention is focused on the implementation and validation of the 'direct tweak' method for the construction of conformationally flexible molecules, such as peptides, from molecular fragments. This flexible fitting method is compared to the original method based on libraries of prestored conformations for each fragment. It is shown that the directed tweak method produces results of comparable quality, with significant time savings. By removing the need to generate a set of representative conformers for any new library fragment, the flexible fitting method increases the speed and simplicity with which new fragments can be included in a fragment library and also reduces the disk space required for library storage. A further improvement to the molecular construction process within PRO_LIGAND is the inclusion of a constrained minimisation procedure which relaxes fragments onto the design model and can be used to reject highly strained structures during the structure generation phase. This relaxation is shown to be very useful in simple test cases, but restricts diversity for more realistic examples. The advantages and disadvantages of these additions to the PRO_LIGAND methodology are illustrated by three examples: similar design to an alpha helix region of dihydrofolate reductase, complementary design to the active site of HIV-1 protease and similar design to an epitope region of lysozyme.

Type A behaviour in the Australian working population.

The Type A behaviour pattern (TABP) has been widely researched in Australian studies and, in view of its increasing prominence beyond its original association with risk of coronary heart disease, is likely to be as widely researched in this country well into the future. The Jenkins Activity Survey (JAS), being the most comprehensive self-report instrument used to assess the TABP, appears to be the instrument of choice for the measurement of the TABP in Australia, particularly in epidemiological studies where large samples are involved, or in other studies where either the interview method is impractical or the researchers are untrained in its application. This paper presents normative data on the use of the JAS in the Australian context, derived from a series of empirical studies undertaken by the authors over the past decade. Sociodemographic correlates of these data are presented, and refinements of the JAS for future use are suggested.

Personality, stress and the decision to commence cigarette smoking in adolescence.

Adolescent cigarette smoking is an increasing health risk behaviour in many societies. The reasons why adolescents commence smoking are patently complex, though it has been suggested that young people take up this behaviour as a means of stress reduction during the difficult and challenging time of adolescence. This paper reports data which suggests that adolescent stress, broadly defined, does indeed relate to the decision to commence smoking by young people. Moreover, though the personality attribute of neuroticism is independently associated with this decision, it does not mediate the association between stress and smoking onset. The implications of these data for adolescent smoking prevention programs are discussed.

The effect of exercise on depression, anxiety and other mood states: a review.

This paper addresses the current literature related to investigations of the link between exercise treatments and depression, anxiety and other mood states. Results from these investigations are supportive of the anti-depressant, anti-anxiety and mood enhancing effects of exercise programs. There were considered to be, however, a number of potential methodological problems in many of the research studies; the nature of these were considered. Finally, some possible directions for future research are outlined.

Type A behaviour and the authoritarian personality.

The demonstration of modest statistical associations between measures of the Type A behaviour pattern (TABP) and some measures of authoritarianism has given rise to a view that the TABP represents little more than an attempt by some individuals to exercise the personality attribute of dominance. The present study examined this view with regard to a wide selection of measures of the authoritarian personality and found that measures of the TABP related only to measures of authoritarianism reflecting authoritarian behaviours. While such correlations indicate a facet of the TABP resembles the attribute of dominance, they do not amount to conceptual equivalence of the TABP and authoritarianism. The conceptual complexity of the TABP demands a more multidimensional view of this explanatory notion in medical psychology.