RESUMO
We report a 44-year-old with progressive quadriparesis due to a dumbbell malignant peripheral nerve sheath tumour (MPNST) of the second cervical nerve, 17 years after whole brain radiotherapy for a pineal germinoma. To our knowledge this is the first case of radiation induced high cervical MPNST arising from a benign neurofibroma.
Assuntos
Plexo Cervical/efeitos da radiação , Irradiação Craniana/efeitos adversos , Neoplasias de Bainha Neural/diagnóstico , Neoplasias de Bainha Neural/etiologia , Neurofibroma/complicações , Quadriplegia/etiologia , Neoplasias da Medula Espinal/complicações , Adulto , Germinoma/radioterapia , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Neoplasias de Bainha Neural/complicações , Neoplasias de Bainha Neural/patologia , Neoplasias de Bainha Neural/cirurgia , Neurofibroma/etiologia , Pinealoma/radioterapia , Neoplasias da Medula Espinal/etiologiaRESUMO
We report a 30-year-old male who had undergone a renal transplant and suffered with secondary hyperparathyroidism. He presented with back pain and minimal neurological deterioration, caused by a thoracic brown tumour. The imaging findings, surgical treatment of the spinal lesion and outcome are discussed. We also discuss primary medical therapy and suggest a rational approach to further imaging of patients in whom brown tumour is suspected.
Assuntos
Transplante de Rim , Neoplasias da Coluna Vertebral/complicações , Adulto , Marcha/fisiologia , Humanos , Hiperparatireoidismo Secundário/complicações , Falência Renal Crônica/complicações , Falência Renal Crônica/cirurgia , Imageamento por Ressonância Magnética , Masculino , Compressão da Medula Espinal/etiologia , Compressão da Medula Espinal/cirurgia , Neoplasias da Coluna Vertebral/patologia , Neoplasias da Coluna Vertebral/cirurgiaRESUMO
In 1998, one of us (MJM) published an article discussing several patients with Osler-Weber-Rendu Syndrome or hereditary haemorrhagic telangiectasia with secondary cerebral complications. These were intracerebral haemorrhage, ischaemic infarct and intracerebral abscess. We outlined the background of the syndrome as well as its genotype and predicted an increasingly important role for genetic testing. Our aim in this paper is to examine the progress of one of the patients as well as recommending follow-up guidelines for patients with pulmonary arteriovenous fistulae that have been treated.
