[The effect of Moradol (butorphanol tartrate) on immunity]. / Vliianie moradola (butorfanola-tartrata) na immunitet.

Two groups (with n = 5 in each group) were studied of essentially healthy volunteers by double-blind method. Those subjects in group 1 were administered placebo, those in group 2 received 0.1 mg/kg of moradole. In both groups, blood to be analysed was taken in fixed time intervals. An investigation designed to study immunological parameters involved correlation of results obtained before and after administration of moradole or placebo. Opioid agonists are endowed with marked immunity-inhibiting effect disappearing after the administration of naloxone. A hypothesis has been formed to the effect that those drug preparations endowed with agonist-antagonist activity toward opioid receptors fail to induce immunodepression, otherwise it is less pronounced than that of opioid agonists. The studies made allow a conclusion to be reached that administration of moradole is not associated with immunodepression.

[The interaction of clofelin and ketamine in the body of patients]. / Vzaimodeistvie klofelina i ketamina v organizme bol'nykh.

UNLABELLED: Overall thirty-three patients (two groups) I-III ASA operated on with no premedication were examined. In group K an effective dose of ketamine (EDK) was determined, inducing unconsciousness during the intravenous administration with the aid of a dose-metering device. Because of an inadequate sedative effect, determining the effective dose of clonidine in the same way was found to be impossible without exceeding too much the permissible dose. 30 minutes after intravenous administration of a standard dose of clonidine (SDCl) we started infusing ketamine in group "KCl" as we did in group K. ED of ketamine was determined once again against the background of the action of clonidine (EDKCl). Deriving proportions by known EDK, EDKCl, and SDCl, a "mythical" dose EDCl was calculated. According to the published literature man loses consciousness with the dose exceeding the estimated EDCl 33.8-67.5-fold. CONCLUSION: interaction of clonidine and ketamine in the organism of patients is synergic by nature.

[The interaction of moradol (butorphanol tartrate) and flormidal (midazolam) in the patient's body]. / Vzaimodeistvie moradola (butorfanola tartrata) i flormidala (midazolama) v organizme bol'nykh.

Twenty five female patients (3 groups) operated on for cholelithiasis without premedication have been examined. In patients of group F an effective flormidal dose (EFD) causing an unconscious state upon intravenous injection by a measuring device has been determined. Due to an insufficient sedative effect of moradol it was impossible to determine an effective moradol dose (EMD). In group M+F right after intravenous administration of a standard moradol dose (SMD) flormidal infusion was begun, as in patients of group F. EFD after moradol injection (EFMD) was determined. Making proportions with known EFD, EFMD and SMD values, EMD was calculated. Upon intravenous administration of the calculated EMD by a measuring device the sedative effect was superficial in all the patients of group M and it was impossible to achieve an unconscious state. The interaction of moradol (butorphanol tartrate) and flormidal (midazolam) in the patients' body is of synergic nature.