RESUMO
Planteamos un paciente de 62 años que precisa tratamiento hipolipemiante con inhibidor de la proproteína convertasa subtilisina/kexina tipo9 (PCSK9) en el que empíricamente decidimos cambiar un fármaco a otro de los dos disponibles en la actualidad, obteniendo diferente respuesta. Nuestro objetivo es transmitir nuestra experiencia y reflexionar sobre una posible opción terapéutica en los pacientes en los que excepcionalmente esto pudiera ocurrir
The case is presented of a 62-year-old patient who required lipid-lowering therapy with proprotein convertase subtilisin/kexin type9 (PCSK9). It was empirically decided to change one drug to another of the two currently available, obtaining a different response. Our objective is to present our experience and to consider a possible therapeutic option in patients in whom, exceptionally, this could happen
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Pró-Proteína Convertase 9/administração & dosagem , Pró-Proteína Convertases/antagonistas & inibidores , Inibidores de Proteases/farmacologia , Hipercolesterolemia/tratamento farmacológico , Pressão Arterial/efeitos dos fármacos , Pró-Proteína Convertases/metabolismo , Índice de Massa Corporal , Lipoproteínas LDL/efeitos dos fármacosRESUMO
The case is presented of a 62-year-old patient who required lipid-lowering therapy with proprotein convertase subtilisin/kexin type9 (PCSK9). It was empirically decided to change one drug to another of the two currently available, obtaining a different response. Our objective is to present our experience and to consider a possible therapeutic option in patients in whom, exceptionally, this could happen.
Assuntos
Anticolesterolemiantes/administração & dosagem , Hipercolesterolemia/tratamento farmacológico , Inibidores de PCSK9 , Anticolesterolemiantes/farmacologia , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
Describimos un caso, en una mujer de mediana edad, de hipertensión arterial con diferencias de tensión arterial entre ambos brazos, secundaria a secuelas de arteritis de Takayasu, con afectación de troncos supraaórticos y aorta abdominal y estenosis ligera de ambas arterias renales e infartos corticales renales bilaterales. Del total de los pacientes con esta entidad, 80-90% son del género femenino, con inicio de la enfermedad entre los 10 y los 40 años de edad. Se caracteriza por la aparición de estenosis y aneurismas localizados o segmentarios de los vasos afectos (AU)
We present the case of a middle aged woman with arterial hypertension in whom the blood pressure was different in both arms. This condition was secondary to sequels of Takayasu arteritis, with involvement of the supraaortic trunk and abdominal aorta and mild stenosis of both renal arteries and bilateral ischemic lesions in both kidneys. Of the total patients affected by this condition, 80-90% are women, aged 10 to 40 years. Takayasu arteritis is characterized by the appearance of stenosis and localized or segmental aneurysms of the affected vessels (AU)
