RESUMO
Objectives: The prevalence of diabetes mellitus type 2 (DMT2) is increasing exponentially worldwide. DMT2 patients have been found to be at a higher risk for bone fractures than the healthy population. Hence, improving our understanding of the impact of antidiabetic drugs on bone metabolism is crucial. Methods: A descriptive, retrospective study involving 106 patients receiving six groups of antidiabetic drugs: insulin; dipeptidylpeptidase four inhibitors (DPP4i); glucagon-like peptide type 1 receptor agonists (GLP1ra); sulfonylureas; sodium-glucose cotransporter two inhibitors (SGLT2i); and pioglitazone, in which osteocalcin (OC), bone alkaline phosphatase (BAP) and C-terminal telopeptide of collagen type 1 or beta-crosslaps (ß-CTx) were determined. Results: ß-CTx concentrations were higher in the patients treated with pioglitazone, as compared to patients treated with DPP4i (p=0.035), SGLT2i (p=0.020) or GLP1ra (p<0.001). The lowest ß-CTx concentrations were observed in the patients treated with GLP1ra. Conclusions: Bone remodeling is influenced by the type of antidiabetic drug administered to DMT2 patients. In our study, the patients who received pioglitazone showed higher ß-CTx concentrations, as compared to patients treated with other types of antidiabetic drugs. This finding highlights the convenience of avoiding these drugs, especially in postmenopausal women with DMT2. GLP1ra drugs were associated with the lowest ß-CTx concentrations, which suggests that these agents could exert beneficial effects on bone metabolism.
RESUMO
OBJETIVO: Aunque la práctica de actividad física (AF) tiene múltiples beneficios, el 30% de personas son inactivas. Cataluña impulsó el Día Mundial de la actividad física (DMAF) como parte de una estrategia más amplia de promoción de la AF. Este trabajo tuvo como objetivo presentar la implementación y evolución 2010-2016. MÉTODOS: Estudio transversal de tendencias. Se impulsó la celebración del DMAF mediante la web www. pafes.cat, un formulario de registro y un plan de comunicación. Las variables estudiadas fueron número de entidades, tipos de eventos y participantes, el porcentaje de eventos coordinados, el número de visitas web y el coste. Se realizó un análisis descriptivo univariado y de frecuencias. RESULTADOS: Se realizó la difusión a >9000 direcciones electrónicas/año. Entre 2010 y 2016 se multiplicaron por cinco las entidades organizadoras, eventos y participantes (en 2016 2,8% de la población), durante marzo y abril aumentaron las visitas a la web. Los eventos (caminatas, AF dirigida, deporte y difusión) presentaron coordinación y movilizaron de 25 a 500 personas desde diversos ámbitos. El coste estimado medio fue de 1 céntimo por participante. CONCLUSIONES: El DMAF consiguió llegar a un gran volumen de población con un coste mínimo
OBJECTIVE: Even though physical activity (PA) has multiple benefits, 30% of the population is inactive. Catalonia impulse the World Physical Activity Day (WPAD), as a part of a broader strategy of PA promotion. The objetive of this work was to present the implementation and evolution of WPAD from 2010 to 2016. METHODS: Repeated cross-sectional study. WPAD celebration was promoted through the web www.pafes. cat, a registry form, and a communication plan. Studied variables were: n. of entities, events (type) and participants, % of coordinated events, number of web visits and cost. A descriptive univariate analysis and calculation of frequencies was done. RESULTS: Spreading was done to >9000 electronic addresses per year. Between 2010 and 2016 organizing entities, events and participants (2,8% of population in 2016) multiplied by 5. Organized events (walks, supervised PA, sport and diffusion) were done in coordination and mobilized 25 to 500 people, from a variety of settings. Estimated mean cost was 1 cent of euro by participant. CONCLUSIONS: WPAD managed to reach an important amount of population at a minimum cost
