RESUMO
Three novel betaine alkaloids, called aminozooanemonin (1), pyridinebetaine A (2), and pyridinebetaine B (3), have been isolated from the Caribbean sponge Agelas dispar. Their structures were determined by FABMS, IR, UV, and 1D and 2D NMR spectroscopic experiments. Aminozooanemonin and pyridinebetaine A showed moderate antibacterial activity.
Assuntos
Antibacterianos/farmacologia , Betaína/análogos & derivados , Poríferos/química , Animais , Bactérias/efeitos dos fármacos , Betaína/isolamento & purificação , Betaína/farmacologia , Cromatografia Líquida de Alta Pressão , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Espectrometria de Massas de Bombardeamento Rápido de Átomos , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
Further investigation of the Caribbean marine sponge Agelas dispar for biologically active constituents has led to the isolation of the novel bromopyrrole alkaloids longamide B (1), and clathramides C (2) and D (3), whose structures have been determined by spectroscopic methods. Isolation of the known keramadine (4) and of the ecdysonic sterols ecdysterone (5) and ajugasterone C (6) is also reported. The antimicrobial activities of the isolated bromopyrrole alkaloids is summarized.
Assuntos
Alcaloides/química , Antibacterianos/farmacologia , Poríferos/química , Alcaloides/farmacologia , Animais , Bacillus subtilis/efeitos dos fármacos , Cromatografia Líquida de Alta Pressão , Testes de Sensibilidade Microbiana , Espectrofotometria Ultravioleta , Staphylococcus aureus/efeitos dos fármacosRESUMO
Hydrocarbons, triterpenoids and sterols were determined in Stenomesson variegatum (R. et P.) Macbr. (Amaryllidaceae), a plant used in traditional peruvian medicine as an antiinflammatory. An unusual presence of odd hydrocarbons was found, whereas triterpenoidic and sterolic fractions are quite usual and simple.
