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1.
Acad Pediatr ; 15(4): 444-50, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26142071

RESUMO

OBJECTIVE: To assess the accuracy of International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM), codes in identifying cases of child physical abuse in 4 children's hospitals. METHODS: We included all children evaluated by a child abuse pediatrician (CAP) for suspicion of abuse at 4 children's hospitals from January 1, 2007, to December 31, 2010. Subjects included both patients judged to have injuries from abuse and those judged to have injuries from accidents or to have medical problems. The ICD-9-CM codes entered in the hospital discharge database for each child were compared to the decisions made by the CAPs on the likelihood of abuse. Sensitivity and specificity were calculated. Medical records for discordant cases were abstracted and reviewed to assess factors contributing to coding discrepancies. RESULTS: Of 936 cases of suspected physical abuse, 65.8% occurred in children <1 year of age. CAPs rated 32.7% as abuse, 18.2% as unknown cause, and 49.1% as accident/medical cause. Sensitivity and specificity of ICD-9-CM codes for abuse were 73.5% (95% confidence interval 68.2, 78.4), and 92.4% (95% confidence interval 90.0, 94.0), respectively. Among hospitals, sensitivity ranged from 53.8% to 83.8% and specificity from 85.4% to 100%. Analysis of discordant cases revealed variations in coding practices and physicians' notations among hospitals that contributed to differences in sensitivity and specificity of ICD-9-CM codes in child physical abuse. CONCLUSIONS: Overall, the sensitivity and specificity of ICD-9-CM codes in identifying cases of child physical abuse were relatively low, suggesting both an under- and overcounting of abuse cases.


Assuntos
Maus-Tratos Infantis/diagnóstico , Codificação Clínica , Classificação Internacional de Doenças , Abuso Físico , Criança , Pré-Escolar , Feminino , Hospitais Pediátricos , Humanos , Lactente , Masculino , Sensibilidade e Especificidade , Estados Unidos
2.
Proc Natl Acad Sci U S A ; 103(44): 16153-8, 2006 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-17053065

RESUMO

A previously undescribed isoelectric focusing technology allows cell signaling to be quantitatively assessed in <25 cells. High-resolution capillary isoelectric focusing allows isoforms and individual phosphorylation forms to be resolved, often to baseline, in a 400-nl capillary. Key to the method is photochemical capture of the resolved protein forms. Once immobilized, the proteins can be probed with specific antibodies flowed through the capillary. Antibodies bound to their targets are detected by chemiluminescence. Because chemiluminescent substrates are flowed through the capillary during detection, localized substrate depletion is overcome, giving excellent linearity of response across several orders of magnitude. By analyzing pan-specific antibody signals from individual resolved forms of a protein, each of these can be quantified, without the problems associated with using multiple antibodies with different binding avidities to detect individual protein forms.


Assuntos
Focalização Isoelétrica/métodos , Proteínas/metabolismo , Transdução de Sinais , Linhagem Celular Tumoral , Humanos , Ponto Isoelétrico , Fosforilação , Isoformas de Proteínas/metabolismo , Sensibilidade e Especificidade
4.
Arch Pediatr Adolesc Med ; 159(6): 561-6, 2005 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15939856

RESUMO

OBJECTIVE: Describe the effect of an educational intervention on medical provider knowledge and competency regarding child sexual abuse. DESIGN: Using a before and after trial design with an educational intervention, the study assesses knowledge changes in specific content areas and describes a post-intervention competency assessment. SETTING/ PARTICIPANTS: Voluntary participation of practicing medical providers and pediatric residents. Intervention Completion of a self-study, case-based, published learning curriculum on child sexual abuse, including a work book and videotaped genital examinations. MAIN OUTCOME MEASURES: Pre- and post-intervention multiple choice and short answer (30 questions) test results as well as a written response to a clinical case scenario. RESULTS: Sixty-four participants completed pre- and post-tests. The average posttest score (26.9/30, SD = 4.13) was significantly higher (P< .001) than the average pretest score (20.4/30, SD = 1.65). More than half (59.4%) of providers did not correctly interpret the exam findings, 28.1% did not correctly reassure the child and family, and 39.1% did not indicate an appropriate understanding of the legal implications. CONCLUSIONS: Motivated medical providers demonstrated significant knowledge gains regarding the evaluation of child sexual abuse following participation in the educational program. This new knowledge was not enough to provide competency in the interpretation of genital findings or in offering legal advocacy to the families. Competence in these areas may in fact represent the domain of experts, not primary care providers, and further studies are needed to determine how much experience is necessary to provide competency in these areas.


Assuntos
Abuso Sexual na Infância/diagnóstico , Competência Clínica , Educação Médica Continuada , Criança , Abuso Sexual na Infância/prevenção & controle , Avaliação Educacional , Pessoal de Saúde , Humanos , Medicina , Especialização , Estados Unidos
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