[Clinical observation of music therapy combined with anti-tumor drugs in treating 116 cases of tumor patients].

OBJECTIVE: To observe the clinical effect of music therapy in treating tumor patients. METHODS: Music therapy combined with anti-tumor drugs, including chemotherapy and Chinese drugs, was given to 162 tumor patients according to syndrome differentiation to observe the change of self-rating depression scale (SDS), self-rating anxiety scale (SAS), minnesota multiphasic personality inventory (MMPI), Hamilton rating scale for depression (HAMD) and T lymphocyte subsets (immuno-histochemical assay), NK cell anti-tumor activity (NAG method), etc. while 46 caces didn't receive music therapy were taken as the control group. RESULTS: The scale marks of SDS and SAS of the treated group after treatment were obviously lower than that of the control group significantly (P < 0.05, P < 0.01). After treatment, the average values of MMPI on falseness (F), hypochondriasis (HS), depression (D) and psychosthenia (Pt) in the treated group were all improved (P < 0.01 or P < 0.05); but in the control group, significant difference only showed in MMPI on HS (P < 0.05). HAMD in the treated group revealed some improvement in insomnia, early awakening, daily work and interest, systemic symptoms and hypochondriasis (P < 0.05), and significant improvement in depression, difficulty in falling asleep, psychiatric anxiety and somatic anxiety (P < 0.01); while in the control group, only work interest and HS had some improvement (P < 0.05). CD8 percent was reduced in both groups after treatment (P < 0.01), but in the treated group CD3, CD4 and CD4/CD8 ratio were not significantly changed after treatment (P > 0.05); while in the control group they lowered obviously (P < 0.05). As for NK cell anti-tumor activity in the treated group before and after treatment, it was not significantly lowered (P > 0.05); while in the control group the lowering after treatment was significant (P < 0.05). CONCLUSION: Music therapy could regulate the emotion of tumor patient, optimize the emotional effect, improve the somatic symptoms, enhance the immune function, motivate the active principle and raise the self-regulating power in the body.

[Histochemical study of estrogen and progesterone receptors in cervical carcinoma]. / Histochemische Bestimmung der Ostrogen- und Progesteronrezeptoren beim Zervixkarzinom.

Estrogen and progesterone receptors were determined in 56 cases of primary cervical carcinoma tissue by histochemical methods. 42.86% of the 56 cases were ER positive and 46.43% PR positive. No correlation was found between ER and PR status and age, menopausal status of the patient and clinical stage. Adenocarcinoma had significantly higher ER and PR positive rate than squamous carcinoma. Highly differentiated carcinoma had higher ER and PR positive rate than middle- and dedifferentiated carcinoma. A positive correlation between ER and PR and cellular infiltration of stroma and peritumoral reaction of fibrin was found. The patients with ER and PR positive had a significantly higher 5-year survival. ER and PR may be used as prognostic factors in cervical carcinoma.

[Serum ribonuclease in patients with malignant tumor of the ovary].

The clinical significance of serum ribonuclease (RNase) was studied in patients with malignant tumor of the ovary, and the result was compared with serum sialic acid (SA). Serum RNase and SA level were determined in 190 women consisting of 35 normal women, 34 patients with ovarian cancer, 39 patients with other malignant gynecological tumors, 38 ovarian cancer patients with clinical remission after treatment and 44 patients with benign gynecological tumor. The sensitivity of serum RNase was 82.4% in the diagnosis of malignant tumor of the ovary. Serum RNase was positive in 42.9% of patients with minimal residual tumor and 88.9% those with residual tumors greater than 2 cm in diameter. Serum RNase assay is a simple, rapid and reliable method useful in monitoring the course of disease.

[Body temperature changes in cancer patients with yin or yang deficiency and blood stasis syndrome].

The body temperature change of cancer patients with Yin or Yang deficiency and blood stasis syndrome varied within normal limits in a day. The researchers divided 60 cases of cancer patients into Yin or Yang deficiency and blood stasis syndrome groups. Their body temperature was measured 6 times daily with radio thermometer. The results showed: at different time during one day, temperature change of patients in Yin deficiency group fluctuated obviously. The mean temperature of patients in blood stasis group was higher than other two groups. The daily highest temperature of patients in the above two groups appeared at 6:00 pm. Temperature change of patients in Yang deficiency group was stable relatively and the highest temperature appeared at 2:00 pm. The palm temperature of patients who feel dysphoria with feverish sensation in chest, palms and sole was not higher than armpit temperature. These observations should provide new objective bases for clinical measurement time of temperature and syndrome diagnosis.

[Quantitative DNA analysis in epithelial ovarian cancer].

The tumor cell nuclear DNA content was measured in 27 cases of epithelial ovarian cancer. The proliferative activity of the tumor was correlated with the prognosis of the patients. The proportion of G0 and G1 cells of the tumors of the same histologic type varied among individuals. There was a close relationship between the proliferative activity of the tumor and the remission rate, duration of survival and mortality of the patients. The heterogeneity of the proliferative activity of the tumor cells may explain the difference of response to chemotherapy. It is suggested that the quantitative analysis of DNA content may be used as an theoretical and experimental basis for the individualization of treatment.