1.
Org Biomol Chem
; 13(37): 9551-8, 2015 Oct 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26288320
RESUMO
New chiral S,N- and S,P-ligands starting from tert-butanesulfinamide were synthesized in four steps, applying Pd-catalyzed asymmetric allylic substitutions of dimethyl 2-fluoromalonate. The induced effect of the Pd/S,N-ligand catalyst on the enantioselectivity depends on the steric demand of the substituent at the o-position of the pyridine ring. This method produced monofluorinated allylation products in up to high yield with high enantioselectivity.