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1.
Heliyon ; 10(11): e31782, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38841459

RESUMO

This study aimed to determine the association between sleep quality and mental health in COVID-19 carriers in China and evaluate the moderating effects of perceived social support. 1283 asymptomatic COVID-19 carriers were enrolled from March 2022 to April 2022 among Ruijin Jiahe Fangcang shelter hospital in Shanghai, China. They were assessed using the Pittsburgh Sleep Quality Index (PSQI), the General Health Questionnaire (GHQ), and the Perceived Social Support Scale (PSSS) respectively. Participants had an average age of 39.64 years and 59.6 % of whom were male. In total, 34.3 % of participants presented with poor sleep quality; 41.1 % showed bad mental health. Sleep quality was positively related to mental health (r = 0.321, P < 0.001, 95 %CI = 0.267, 0.369) and social support was negatively related to mental health (r = -0.414, P < 0.001, 95 %CI = -0.457, -0.367). Meanwhile, social support played a moderating role between sleep quality and mental health (ß = 0.066, P < 0.05, 95 %CI = 0.016, 0.117). These findings indicate that mental health resulting from the COVID-19 pandemic are increasingly apparent in China and provide a focus on sleep quality for the early prevention of mental health in asymptomatic carriers. And social support may be beneficial to the improvement of mental health, especially for people in crisis (e.g., COVID-19 pandemic).

2.
Infect Dis Ther ; 2024 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-38869840

RESUMO

INTRODUCTION: The United States Centers for Disease Control and Prevention (CDC) advises testing individuals for COVID-19 after exposure or if they display symptoms. However, a deeper understanding of demographic factors associated with testing hesitancy is necessary. METHODS: A US nationwide cross-sectional survey of adults with risk factors for developing severe COVID-19 ("high-risk" individuals) was conducted from August 18-September 5, 2023. Objectives included characterizing demographics and attitudes associated with COVID-19 testing. Inverse propensity weighting was used to weight the data to accurately reflect the high-risk adult US population as reflected in IQVIA medical claims data. We describe here the weighted results modeled to characterize demographic factors driving hesitancy. RESULTS: In the weighted sample of 5019 respondents at high risk for severe COVID-19, 58.2% were female, 37.8% were ≥ 65 years old, 77.1% were White, and 13.9% had a postgraduate degree. Overall, 67% were Non-testers (who indicated that they were unlikely or unsure of their likelihood of being tested within the next 6 months); these respondents were significantly more likely than Testers (who indicated a higher probability of testing within 6 months) to be female (60.2 vs. 54.1%; odds ratio [OR] [95% confidence interval (CI)], 1.3 [1.1‒1.4]), aged ≥ 65 years old (41.5 vs. 30.3%; OR [95% CI] compared with ages 18‒34 years, 0.6 [0.5‒0.7]), White (82.1 vs. 66.8%; OR [95% CI], 1.4 [1.1‒1.8]), and to identify as politically conservative (40.9 vs. 18.1%; OR [95% CI], 2.6 [2.3‒2.9]). In contrast, Testers were significantly more likely than Non-testers to have previous experience with COVID-19 testing, infection, or vaccination; greater knowledge regarding COVID-19 and testing; greater healthcare engagement; and concerns about COVID-19. CONCLUSIONS: Older, female, White, rural-dwelling, and politically conservative high-risk adults are the most likely individuals to experience COVID-19 testing hesitancy. Understanding these demographic factors will help guide strategies to improve US testing rates.

4.
ACS Environ Au ; 4(3): 162-172, 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38765061

RESUMO

The highly excessive uptake of cadmium (Cd) by rice plants is well known, but the transfer pathway and mechanism of Cd in the paddy system remain poorly understood. Herein, pot experiments and field investigation were systematically carried out for the first time to assess the phytoavailability of Cd and fingerprint its transfer pathway in the paddy system under different treatments (slaked lime and biochar amendments), with the aid of a pioneering Cd isotopic technique. Results unveiled that no obvious differences were displayed in the δ114/110Cd of Ca(NO3)2-extractable and acid-soluble fractions among different treatments in pot experiments, while the δ114/110Cd of the water-soluble fraction varied considerably from -0.88 to -0.27%, similar to those observed in whole rice plant [Δ114/110Cdplant-water ≈ 0 (-0.06 to -0.03%)]. It indicates that the water-soluble fraction is likely the main source of phytoavailable Cd, which further contributes to its bioaccumulation in paddy systems. However, Δ114/110Cdplant-water found in field conditions (-0.39 ± 0.05%) was quite different from those observed in pot experiments, mostly owing to additional contribution derived from atmospheric deposition. All these findings demonstrate that the precise Cd isotopic compositions can provide robust and reliable evidence to reveal different transfer pathways of Cd and its phytoavailability in paddy systems.

5.
Bioresour Technol ; 402: 130831, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38734262

RESUMO

Mercury (Hg), particularly organic mercury, poses a global concern due to its pronounced toxicity and bioaccumulation. Bioremediation of organic mercury in high-salt wastewater faces challenges due to the growth limitations imposed by elevated Cl- and Na+ concentrations on microorganisms. In this study, an isolated marine bacterium Alteromonas macleodii KD01 was demonstrated to degrade methylmercury (MeHg) efficiently in seawater and then was applied to degrade organic mercury (MeHg, ethylmercury, and thimerosal) in simulated high-salt wastewater. Results showed that A. macleodii KD01 can rapidly degrade organic mercury (within 20 min) even at high concentrations (>10 ng/mL), volatilizing a portion of Hg from the wastewater. Further analysis revealed an increased transcription of organomercury lyase (merB) with rising organic mercury concentrations during the exposure process, suggesting the involvement of mer operon (merA and merB). These findings highlight A. macleodii KD01 as a promising candidate for addressing organic mercury pollution in high-salt wastewater.


Assuntos
Alteromonas , Biodegradação Ambiental , Mercúrio , Mercúrio/metabolismo , Alteromonas/metabolismo , Águas Residuárias/química , Poluentes Químicos da Água/metabolismo , Água do Mar/microbiologia , Aerobiose , Compostos de Metilmercúrio/metabolismo
6.
Prev Med ; 184: 107985, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38705485

RESUMO

OBJECTIVE: This observational study examined the factors associated with the physical activity (PA) of children and adolescents outside of school within the framework of Problem Behavior Theory (PBT). METHODS: This cross-sectional study obtained data from 6528 children and adolescents aged 6-16 years recruited from ten schools in Shanghai, China. The questionnaire measured out-of-school PA and PBT-based correlates. A series of multiple linear regressions were used to explore the factors influencing children and adolescents' out-of-school PA separately. Structural equation modeling (SEM) was used to explore the association between the three systems of PBT and out-of-school PA. RESULTS: Higher intrinsic motivation is positively associated with increased PA for children (b = 1.038, 95%CI: 0.897-1.180) and adolescents (b = 1.207, 95%CI: 0.890-1.524). Greater frequency of parental involvement in PA correlates with elevated PA for both children (b = 2.859, 95%CI: 2.147-3.572) and adolescents (b = 2.147, 95%CI: 0.311-3.983). In children, increased use of community exercise areas or facilities (b = 1.705, 95%CI: 0.234-3.176) and higher recreational screen time (b = 9.732, 95%CI: 5.614-13.850) are associated with higher PA. The SEM showed that factors of the personality system had a significant direct effect on out-of-school PA among children and adolescents, and factors of the behavior system also had a significant effect on children. CONCLUSIONS: Our findings suggest that the personality system, particularly intrinsic motivation, is important in promoting out-of-school PA in children and adolescents. For children, modifiable health behaviors in the behavior system can similarly influence PA.


Assuntos
Exercício Físico , Motivação , Humanos , Estudos Transversais , Masculino , Feminino , Exercício Físico/psicologia , China , Adolescente , Criança , Inquéritos e Questionários , Instituições Acadêmicas , Comportamento Problema/psicologia , População do Leste Asiático
7.
Water Res ; 258: 121792, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38772318

RESUMO

Coastal seas contribute the majority of human methylmercury (MeHg) exposure via marine fisheries. The terrestrial area surrounding the Bohai Sea and Yellow Sea (BS and YS) is one of the mercury (Hg) emission "hot spots" in the world, resulting in high concentrations of Hg in BS and YS seawater in comparison to other marine systems. However, comparable or even lower Hg levels were detected in seafood from the BS and YS than other coastal regions around the word, suggesting a low system bioaccumulation of Hg. Reasoning a low system efficiency of MeHg production (represented by MeHg/THg (total Hg) in seawater) may be present in these two systems, seven cruises were conducted in the BS and YS to test this hypothesis. MeHg/THg ratios in BS and YS seawater were found to be lower than that in most coastal systems, indicating that the system efficiency of MeHg production is relatively lower in the BS and YS. The low system efficiency of MeHg production reduces the risk of Hg in the BS and YS with high Hg discharge intensity. By measuring in situ production and degradation of MeHg using double stable isotope addition method, and MeHg discharge flux from various sources and its exchange at various interfaces, the budgets of MeHg in the BS and YS were estimated. The results indicate that in situ methylation and demethylation are the major source and sink of MeHg in the BS and YS. By comparing the potential controlling processes and environmental parameters for MeHg/THg in the BS and YS with the other coastal seas, estuaries and bays, lower transport efficiency of inorganic Hg from water column to the sediment, slower methylation of Hg, and rapid demethylation of MeHg were identified to be major reasons for the low system efficiency of MeHg production in the BS and YS. This study highlights the necessity of monitoring the system efficiency of MeHg production, associated processes, and controlling parameters to evaluate the efficiency of reducing Hg emissions in China as well as the other countries.


Assuntos
Monitoramento Ambiental , Compostos de Metilmercúrio , Água do Mar , Poluentes Químicos da Água , Água do Mar/química , Oceanos e Mares , China , Mercúrio
8.
J Affect Disord ; 360: 42-49, 2024 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-38815759

RESUMO

BACKGROUND: HIV-positive men who have sex with men (MSM) are at high risk of suicide and experience intersectional inequalities. The Social Determinants of Health (SDH) framework provides valuable insights into how inequalities can lead to adverse outcomes. This study aimed to employ the SDH framework to identify factors that contribute to suicidal behaviors among this population. METHODS: 1410 HIV-positive MSM were recruited using a web-based questionnaire, whose mean age was 30.77 ± 6.92 years old. Participants completed questionnaires including baseline information and psychological measurements, such as Suicidal Behaviors Questionnaire-Revised (SBQ-R). Logistic regression analysis was conducted to screen for risk factors associated with suicidal behaviors. RESULTS: More than half of the participants (53.3 %, 752/1410) had an SBQ score of 7 or higher. Binary logistic regression analysis of structural and intermediary determinants (Model 3) revealed that sexual orientation, stigma (ORs: 1.018, 95 % CI: 1.005-1.032), interpersonal needs (ORs: 1.021, 95 % CI: 1.010-1.031), depression (ORs: 1.037, 95 % CI: 1.001-1.074) and entrapment (ORs: 1.018, 95 % CI: 1.004-1.032) were positively correlated with suicidal behaviors. Individuals with other or unknown sexual orientation had significantly higher rates of suicidal behaviors compared to those with a heterosexual sexual orientation (ORs: 5.021, 95 % CI: 1.529-17.640). LIMITATIONS: Sampling of HIV-positive MSM posed challenges in data collection. It may introduce selection bias and affect generalizability. CONCLUSION: This study identified that sexual orientation, stigma, interpersonal needs, depression, and entrapment were significantly associated with suicidal behaviors among HIV-positive MSM. Additionally, these factors can be social determinants of health that contribute to suicidal behaviors.


Assuntos
Homossexualidade Masculina , Determinantes Sociais da Saúde , Estigma Social , Ideação Suicida , Humanos , Masculino , Adulto , Homossexualidade Masculina/estatística & dados numéricos , Homossexualidade Masculina/psicologia , China/epidemiologia , Fatores de Risco , Infecções por HIV/epidemiologia , Infecções por HIV/psicologia , Inquéritos e Questionários , Depressão/epidemiologia , Depressão/psicologia , Adulto Jovem , Tentativa de Suicídio/estatística & dados numéricos , Minorias Sexuais e de Gênero/estatística & dados numéricos , Minorias Sexuais e de Gênero/psicologia , Suicídio/estatística & dados numéricos , Suicídio/psicologia , Comportamento Sexual/estatística & dados numéricos , Comportamento Sexual/psicologia
9.
J Hazard Mater ; 473: 134711, 2024 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-38795491

RESUMO

Coastal wetland soils play a critical role in the global mercury (Hg) cycle, serving as both an important repository for total mercury (THg) and a hotspot for methylmercury (MeHg) production. This study investigated Hg pollution in soils dominated by Phragmites australis (PA) and Spartina alterniflora (SA) across five representative China's coastal wetlands (Yellow River (YR), Linhong River (LHR), Yangtze River (CJR), Min River (MR), and Nanliu River (NLR)). The THg concentrations ranged from 16.7 to 446.0 (96.3 ± 59.3 ng g-1, dw), while MeHg concentrations varied from 0.01 to 0.81 (0.12 ± 0.12 ng g-1, dw). We further evaluated Hg risk in these wetlands using potential ecological risk index (Er) and geographical enrichment factor (Igeo). Most wetlands exhibited low to moderate ecological risk, except the PA habitat in the YR wetland, showing moderate to high risk. Soil organic matter significantly influenced THg and MeHg distribution, while MeHg% correlated well with soil salinity and pH. These findings highlight the importance of organic-rich coastal wetland soils in THg and MeHg accumulation, with the soil properties influencing net MeHg production. Furthermore, SA habitat generally exhibited higher MeHg%, suggesting its invasion elevates the ecological risk of MeHg in coastal wetlands. ENVIRONMENTAL IMPLICATION: Mercury (Hg), a global pollutant, poses great risks to wildlife and humans. Since industrialization, anthropogenic Hg release surpassed natural sources. Long-term exposure leads to biomagnification of Hg. This study assessed Hg and methylmercury pollution and risks in soils of five China's coastal wetlands dominated by Phragmites australis and Spartina alterniflora. Environmental factors (total carbon, total organic carbon, total nitrogen, salinity, pH) were analyzed to reveal key variables influencing Hg pollution and methylation. Essential for quantifying Hg pollution in coastal wetlands, the findings provide a scientific basis for effective wetland conservation policies and addressing environmental health in these regions.


Assuntos
Monitoramento Ambiental , Mercúrio , Compostos de Metilmercúrio , Poluentes do Solo , Áreas Alagadas , Compostos de Metilmercúrio/análise , China , Mercúrio/análise , Poluentes do Solo/análise , Solo/química
10.
Environ Sci Technol ; 58(15): 6825-6834, 2024 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-38567993

RESUMO

Hg(I) may control Hg redox kinetics; however, its metastable nature hinders analysis. Herein, the stability of Hg(I) during standard preparation and analysis was studied. Gravimetric analysis showed that Hg(I) was stable in its stock solution (1000 mg L-1), yet completely disproportionated when its dilute solution (10 µg L-1) was analyzed using liquid chromatography (LC)-ICPMS. The Hg(I) dimer can form through an energetically favorable comproportionation between Hg(0) and Hg(II), as supported by density functional theory calculation and traced by the rapid isotope exchange between 199Hg(0)aq and 202Hg(II). However, the separation of Hg(0) and Hg(II) (e.g., LC process) triggered its further disproportionation. Polypropylene container, increasing headspace, decreasing pH, and increasing dissolved oxygen significantly enhanced the disproportionation or redox transformations of Hg(I). Thus, using a glass container without headspace and maintaining a slightly alkaline solution are recommended for the dilute Hg(I) stabilization. Notably, we detected elevated concentrations of Hg(I) (4.4-6.1 µg L-1) in creek waters from a heavily Hg-polluted area, accounting for 54-70% of total dissolved Hg. We also verified the reductive formation of Hg(I) in Hg(II)-spiked environmental water samples, where Hg(I) can stably exist in aquatic environments for at least 24 h, especially in seawater. These findings provide mechanistic insights into the transformation of Hg(I), which are indicative of its further environmental identification.


Assuntos
Mercúrio , Poluentes Químicos da Água , Mercúrio/análise , Água do Mar/análise , Água do Mar/química , Isótopos/análise , Poluentes Químicos da Água/análise
11.
J Hazard Mater ; 470: 134113, 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38565021

RESUMO

Photo-induced degradation of dimethylmercury (DMHg) is considered to be an important source for the generation of methylmercury (MMHg). However, studies on DMHg photodegradation are scarce, and it is even debatable about whether DMHg can be degraded in natural waters. Herein, we found that both DMHg and MMHg could be photodegraded in three natural waters collected from the Yellow River Delta, while in pure water only DMHg photodegradation occurred under visible light irradiation. The effects of different environmental factors on DMHg photodegradation were investigated, and the underlying mechanisms were elucidated by density functional theory calculations and a series of control experiments. Our findings revealed that the DMHg degradation rate was higher in the tidal creek water compared to Yellow River, Yan Lake, and purified water. NO3-, NO2-, and DOM could promote the photodegradation with DOM and NO3- showing particularly strong positive effects. Different light sources were employed, and UV light was found to be more effective in DMHg photodegradation. Moreover, MMHg was detected during the photodegradation of DMHg, confirming that the photochemical demethylation of DMHg is a source of MMHg in sunlit water. This work may provide a novel mechanistic insight into the DMHg photodegradation in natural waters and enrich the study of the global biogeochemical cycle of Hg.


Assuntos
Compostos de Metilmercúrio , Fotólise , Poluentes Químicos da Água , Compostos de Metilmercúrio/química , Compostos de Metilmercúrio/análise , Compostos de Metilmercúrio/efeitos da radiação , Poluentes Químicos da Água/química , Poluentes Químicos da Água/efeitos da radiação , Poluentes Químicos da Água/análise , Luz , Raios Ultravioleta , Nitratos/química , Nitratos/análise , Rios/química
12.
Environ Sci Technol ; 58(18): 7860-7869, 2024 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-38647522

RESUMO

Algae are an entry point for mercury (Hg) into the food web. Bioconcentration of Hg by algae is crucial for its biogeochemical cycling and environmental risk. Herein, considering the cell heterogeneity, we investigated the bioconcentration of coexisting isotope-labeled inorganic (199IHg) and methyl Hg (201MeHg) by six typical freshwater and marine algae using dual-mass single-cell inductively coupled plasma mass spectrometry (scICP-MS). First, a universal pretreatment procedure for the scICP-MS analysis of algae was developed. Using the proposed method, the intra- and interspecies heterogeneities and the kinetics of Hg bioconcentration by algae were revealed at the single-cell level. The heterogeneity in the cellular Hg contents is largely related to cell size. The bioconcentration process reached a dynamic equilibrium involving influx/adsorption and efflux/desorption within hours. Algal density is a key factor affecting the distribution of Hg between algae and ambient water. Cellular Hg contents were negatively correlated with algal density, whereas the volume concentration factors almost remained constant. Accordingly, we developed a model based on single-cell analysis that well describes the density-driven effects of Hg bioconcentration by algae. From a novel single-cell perspective, the findings improve our understanding of algal bioconcentration governed by various biological and environmental factors.


Assuntos
Mercúrio , Mercúrio/metabolismo , Espectrometria de Massas , Compostos de Metilmercúrio/metabolismo , Poluentes Químicos da Água/metabolismo , Cadeia Alimentar , Análise de Célula Única
13.
Sci Total Environ ; 931: 172845, 2024 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-38685427

RESUMO

Mercury (Hg) is one of the toxic metals of global and environmental concern, with aquatic Hg cycling being central in determining the production of highly toxic methylmercury and the air-water Hg exchange influencing the long-range intercontinental atmospheric Hg transport. Both inorganic and organic forms of Hg can be bound by suspended particles, including inorganic minerals (in particular metal oxides/sulfides) and particulate organic matter. Photochemical transformation is a critical process in surface water, and the role of suspended particles in Hg redox photoreactions has increasingly emerged, albeit in limited studies in comparison to extensive studies on aqueous (homogeneous) photoreactions of Hg. The lack of understanding of what roles suspended particles play might result in inaccurate estimation of how Hg species transform and/or cycle in the environment. In view of this gap, this paper critically reviews and synthesizes information on the studies conducted on different natural surface waters with respect to the potential roles of suspended particles on Hg photo-redox reactions. It robustly discusses the various possible pathways and/or mechanisms of particle-mediated Hg (II) reduction, in enhancing or lowering the production of dissolved gaseous mercury. These processes include photo hole-electron pair formation and reactive oxygen species generation from particle excitation and their involvement in Hg photoreduction, in addition to the light attenuation effect of particles. This paper highlights the necessity of future studies exploiting these particles-mediated Hg photoreactions pathways and the implications of including these heterogeneous photoreactions (together with particulate elemental Hg species) on the air-water Hg exchange estimation.

15.
J Cancer Res Clin Oncol ; 150(4): 176, 2024 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-38575793

RESUMO

PURPOSE: Residual lymph node metastases (RLNM) remained a great concern in the implementation of organ-preserving strategies and led to poor prognosis in locally advanced rectal cancer (LARC). In this study, we aimed to identify the clinicopathological factors correlated with RLNM in LARC patients with ypT0-2 after neoadjuvant chemoradiotherapy (NCRT). METHODS: We retrospectively analyzed 417 patients histologically diagnosed middle-low LARC after NCRT and total mesorectal excision (TME), whose pathological staging was ypT0-2. All patients received pelvic magnetic resonance imaging (MRI) before NCRT. The radiation doses were 50-50.6 Gy for the planning gross tumor volume and 41.8-45 Gy for the planning target volume, respectively. A nomogram for predicting RLNM was constructed using a binary logistic regression. Nomogram performance was assessed by receiver operating characteristic (ROC) curve, calibration curve, decision curve analysis (DCA) and clinical impact curve (CIC). RESULTS: After surgery, 191 patients (45.8%) were ypT0, 43 patients (10.3%) were ypT1 and 183 patients (43.9%) were ypT2, and a total of 49 patients (11.8%) were found the presence of RLNM. Multivariable analyses identified MRI-defined mesorectal fascia (MRF)-positive, high-grade histopathology at biopsy, advanced ypT-category, and the presence of perineural invasion (PNI) as the predictive factors. The nomogram, incorporating all these predictors, showed good discrimination and calibration efficacy, with the areas under the ROC curve of 0.690 (95% CI: 0.610-0.771). Both DCA and CIC demonstrated that this nomogram has good clinical usefulness. CONCLUSION: The nomogram model can predict RLNM in patients with ypT0-2 tumors. It can help select suitable patients for performing organ-preserving strategies after NCRT.


Assuntos
Segunda Neoplasia Primária , Neoplasias Retais , Humanos , Terapia Neoadjuvante , Metástase Linfática , Estudos Retrospectivos , Estadiamento de Neoplasias , Neoplasias Retais/terapia , Neoplasias Retais/patologia , Quimiorradioterapia , Quimiorradioterapia Adjuvante , Segunda Neoplasia Primária/patologia
16.
Medicine (Baltimore) ; 103(13): e37526, 2024 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-38552093

RESUMO

The role of serum albumin (ALB) has been extensively studied in patients with cancer; however, research on its effect on bone metastasis in these patients remains limited. This study aimed to investigate the relationship between serum ALB and alkaline phosphatase (ALP) levels in patients with tumors. Using data from the National Health and Nutrition Examination Survey 2011 to 2018, we assessed the correlation between serum ALB and ALP levels using a weighted multivariate linear regression model, whereas a weighted generalized additive model and smooth curve fitting were used to address potential nonlinearities. A total of 1876 patients with cancer were included in our study. In the subgroup analysis stratified by sex, race/ethnicity, and liver disease, the negative correlation of ALB with ALP remained for most groups, except in blacks (ß = -1.755, 95%CI: [-3.848, 0.338], P = .103) and patients with gout (ß = -0.676, 95%CI: [-2.061, 0.709], P = .340). In black people and patients with gout, the relationship between ALB and ALP showed an inverted U-shaped curve, with an inflection point at approximately 42 g/dL. Our study showed an inverse correlation between ALB and ALP levels in most patients with tumors, but not in black patients and those with gout. The measurement of ALB levels can serve as a screening tool for bone metastases while guiding therapeutic intervention strategies.


Assuntos
Neoplasias Ósseas , Gota , Humanos , Albumina Sérica/análise , Fosfatase Alcalina , Inquéritos Nutricionais
18.
Small Methods ; : e2400067, 2024 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-38494754

RESUMO

Wide-bandgap (WBG) perovskite solar cells (PSCs) have been widely used as the top cell of tandem solar cells. However, photoinduced phase segregation and high open-circuit voltage loss pose significant obstacles to the development of WBG PSCs. Here, a two-step small-size A-site and large-size X-site incorporation strategy is reported to modulate the lattice distortion and improve the film quality of WBG formamidinium-methylammonium (FAMA) perovskite films for photostable PSCs based on two-step deposition method. First, CsI with content of 0-20% is introduced to tune the lattice distortion and film quality of FAMA perovskite with a bandgap of 1.70 eV. Then, 4% RbI is incorporated to further modulate the perovskite growth and lattice distortion, leading to the suppression of photoinduced phase segregation in the resultant RbCsFAMA quadruple cation perovskites. As a result, the 20%CsI/4%RbI-doped device obtains a promising efficiency of 20.6%, and the corresponding perovskite film shows good photothermal stability. Even without encapsulation, the device can maintain 92% of its initial efficiency after 1000 h of continuous operation under 1 sun equivalent white light-emitting diode illumination.

19.
Eur J Med Chem ; 269: 116341, 2024 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-38518523

RESUMO

Protein arginine methyltransferase 5 (PRMT5) and epidermal growth factor receptor (EGFR) are both involved in the regulation of various cancer-related processes, and their dysregulation or overexpression has been observed in many types of tumors. In this study, we designed and synthesized a series of 1-phenyl-tetrahydro-ß-carboline (THßC) derivatives as the first class of dual PRMT5/EGFR inhibitors. Among the synthesized compounds, 10p showed the most potent dual PRMT5/EGFR inhibitory activity, with IC50 values of 15.47 ± 1.31 and 19.31 ± 2.14 µM, respectively. Compound 10p also exhibited promising antiproliferative activity against A549, MCF7, HeLa, and MDA-MB-231 cell lines, with IC50 values below 10 µM. Molecular docking studies suggested that 10p could bind to PRMT5 and EGFR through hydrophobic, π-π, and cation-π interactions. Furthermore, 10p displayed favorable pharmacokinetic properties and oral bioavailability (F = 30.6%) in rats, and administrated orally 10p could significantly inhibit the growth of MCF7 orthotopic xenograft tumors. These results indicate that compound 10p is a promising hit compound for the development of novel and effective dual PRMT5/EGFR inhibitors as potential anticancer agents.


Assuntos
Antineoplásicos , Carbolinas , Humanos , Ratos , Animais , Relação Estrutura-Atividade , Simulação de Acoplamento Molecular , Linhagem Celular Tumoral , Proliferação de Células , Antineoplásicos/química , Receptores ErbB , Inibidores de Proteínas Quinases/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Estrutura Molecular , Proteína-Arginina N-Metiltransferases
20.
Maturitas ; 184: 107965, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38460416

RESUMO

BACKGROUND: Sexual and reproductive health (SRH) is critical to the overall health of older adults. We assessed the utilization of SRH services and its correlates among older adults in China. METHODS: We recruited community-dwelling adults aged 50 and above in five Chinese cities between June 2020 and December 2022. In this study SRH services included reproductive health examination, cervical cancer screening, and sexual life counselling. Logistic regression was used to assess correlates of SRH services utilization. RESULTS: A total of 3001 older adults (1819 men and 1182 women) were enrolled. Among them, 11.4 % (343/3001) of participants received a reproductive health examination, 35.4 % (418/1182) of female participants received cervical cancer screening, and 30.1 % (401/1332) of sexually active participants sought help for their sexual lives. Older men with an annual income of USD 7500 or more (aOR = 3.21, 95%CI: 1.39-7.44), two or more chronic conditions (2.38, 1.39-4.08), and reproductive health problems (2.01, 1.18-3.43) were more likely to receive a urological examination. For older women, individuals who were younger (aged 50-59 years: 5.18, 2.84-9.43; aged 60-69 years: 2.67, 1.49-4.79), lived in an urban area (1.88, 1.31-2.71), were employed (1.73, 1.21-2.47), had two or more chronic conditions (2.04, 1.37-3.05), were sexually active (1.72, 1.15-2.58) and talked about sex (1.69, 1.21-2.36) were more likely to receive a gynecological examination. CONCLUSION: SRH services utilization among older adults was low, with urological examination among older men particularly low. SRH messages and services tailored for older adults are needed to enhance their utilization of SRH services.


Assuntos
Serviços de Saúde Reprodutiva , Humanos , Masculino , Feminino , China , Pessoa de Meia-Idade , Idoso , Serviços de Saúde Reprodutiva/estatística & dados numéricos , Saúde Sexual/estatística & dados numéricos , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Saúde Reprodutiva/estatística & dados numéricos , Neoplasias do Colo do Útero , Detecção Precoce de Câncer/estatística & dados numéricos , Comportamento Sexual/estatística & dados numéricos
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