1.
Chem Commun (Camb)
; 50(44): 5887-90, 2014 Jun 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24760345
RESUMO
Copper-catalyzed olefinic difluoroacetylation of enamides via direct C-H bond functionalization using BrCF2CO2Et is reported for the first time. It constitutes an efficient radical-free method for the regioselective synthesis of ß-difluoroester substituted enamides which exhibits broad substrate scope, and thus demonstrates its potent application in a late stage fluorination strategy.