Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients.

Vitamin D deficiency is one of the most common medical conditions, with approximately one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of this research was to evaluate the prevalence of vitamin D deficiency/insufficiency in hospitalized patients focusing on demographic parameters as well as assessing the possibility of its associations with different comorbidities. Of 11,182 Romanian patients evaluated in the study over 2 years, 28.83% had vitamin D deficiency, 32.11% insufficiency and 39.05% had optimal vitamin D levels. The vitamin D deficiency was associated with cardiovascular disorders, malignancies, dysmetabolic disorders and SARS-CoV2 infection, older age and the male sex. Vitamin D deficiency was prevalent and showed pathology association, while insufficiency of vitamin D (20-30 ng/mL) had lower statistical relevance and represents a grey zone in vitamin D status. Guidelines and recommendations are necessary for homogeneity of the monitoring and management of inadequately vitamin D status in the risk categories.

An overview of pharmaceuticals and personal care products contamination along the river Somes watershed, Romania.

The mass flows of selected pharmaceuticals and personal care products (PPCPs) were studied in the aqueous compartment of the river Somes in Romania. PPCPs were measured in wastewater treatment effluents and in the receiving river water. The analytical method for the determination of PPCPs in river water was based on solid phase extraction and GC-ITMS. Carbamazepine, pentoxyfylline, ibuprofen, diazepam, galaxolide, tonalide and triclosan were determined in wastewater effluents with individual concentrations ranging from 15 to 774 ng L(-1). Caffeine was measured at concentrations up to 42 560 ng L(-1). Due to the high contamination of WWTP effluents, the receiving river was also polluted. The most abundant PPCPs measured in the Somes were caffeine, galaxolide, carbamazepine and triclosan. They were present at all the 15 sampling sites along the Somes, the concentrations ranging from 10 to 400 ng L(-1). The concentrations in the effluents of the different wastewater treatment plants (WWTPs) varied considerably and the differences are due to different elimination efficiencies of the studied PPCPs during sewage treatment. Only one of 5 WWTPs studied, the WWTP in Cluj-Napoca, was working properly, and therefore technical measures have to be taken for upgrading the WWTPs and reducing the environmental load of micropollutants. This study is the first overview of PPCPs along on Romanian part of river Somes.