RESUMO
An 8-year-old, castrated male, domestic shorthaired cat was presented for evaluation of a perianal mass. The mass was incompletely excised, and histological assessment resulted in a diagnosis of anal sac adenocarcinoma. The cat had a partial response to carboplatin therapy but a short overall duration of response. Necropsy confirmed the original diagnosis as well as metastasis to the regional lymph nodes and lungs.
Assuntos
Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/veterinária , Neoplasias das Glândulas Anais/tratamento farmacológico , Antineoplásicos/uso terapêutico , Carboplatina/uso terapêutico , Doenças do Gato/tratamento farmacológico , Sacos Anais/patologia , Animais , Gatos , Evolução Fatal , Neoplasias Pulmonares/secundário , Neoplasias Pulmonares/veterinária , Metástase Linfática , Masculino , Recidiva Local de Neoplasia/veterináriaRESUMO
A 2-year-old, male Weimaraner with muscular dystrophy was presented with generalized muscle atrophy of the limbs; hypertrophy of the neck, infraspinatus, and lingual muscles; dysphagia; and regurgitation. Unilateral cryptorchidism, unilateral renal agenesis, and hiatal hernia were also detected. Spontaneous muscle activity was identified on myography. Serum creatine kinase was markedly elevated. Immunohistochemical staining for dystrophin was restricted to suspected revertant (characteristics of immaturity) fibers. Histologically, skeletal myofiber degeneration, endomysial fibrosis, and mineralization were present. Following euthanasia, necropsy revealed hypertrophy of the diaphragm and cardiac muscle fibrosis. This case of muscular dystrophy represents a slowly progressive form with organ agenesis.
