Variation in mothers' arginine vasopressin receptor 1a and dopamine receptor D4 genes predicts maternal sensitivity via social cognition.

We examined the extent to which the arginine vasopressin receptor 1a (AVPR1a) and dopamine receptor D4 (DRD4) were related to sensitive maternal behavior directly or indirectly via maternal social cognition. Participants were 207 (105 European-American and 102 African-American) mothers and their children (52% females). Sensitive maternal behavior was rated and aggregated across a series of tasks when infants were 6 months, 1 year and 2 years old. At 6 months, mothers were interviewed about their empathy, attributions about infant behavior and beliefs about crying to assess their parenting-related social cognition. Mothers with long alleles for AVPR1a and DRD4 engaged in more mother-oriented social cognition (i.e. negative attributions and beliefs about their infants' crying, ß = 0.13, P < 0.05 and ß = 0.16, P < 0.05, respectively), which in turn predicted less sensitive maternal behavior (ß = -0.23, P < 0.01). Both indirect effects were statistically significant independent of one another and covariates [95% confidence interval (CI): -0.22, -0.03 and ß = -0.03 for AVPR; 95% CI: -0.20, -0.03 and ß = -0.04 for DRD4]. There were no significant direct effects of AVPR1a or DRD4 on maternal sensitivity (ß = 0.02, P = .73 and ß = -0.10, P = .57, respectively). The results did not vary for African-American and European-American mothers (Δχ2 = 18.76, Δdf = 16, P = 0.28). Results support the view that one mechanism by which maternal genes are associated with parental behavior is via social cognition.

Predicting weight outcomes in preadolescence: the role of toddlers' self-regulation skills and the temperament dimension of pleasure.

OBJECTIVES: To investigate the role of toddlers' self-regulation skills and temperament in predicting weight outcomes in preadolescence. METHODS: Participants for this study included 195 children (114 girls) obtained from three different cohorts participating in a larger ongoing longitudinal study. At 2 years of age, participants participated in several laboratory tasks designed to assess their self-regulation abilities, including emotion regulation, sustained attention and delay of gratification, whereas parents filled out a temperament questionnaire to assess toddlers' pleasure expression. Height and weight measures were collected when children were 4, 5, 7 and 10 years of age. Children also filled out a body image and eating questionnaire at the 10-year visit. RESULTS: Self-regulation skills in toddlers were associated with body mass index (BMI) development and pediatric obesity as well as body image/eating concerns. The temperament dimension of pleasure was also associated with BMI development and pediatric obesity but not body image/eating concerns. CONCLUSIONS: Self-regulation difficulties across domains as well as temperament-based pleasure in toddlers represented significant individual risk factors for the development of pediatric obesity 8 years later. Early self-regulation difficulties also contributed to body image and eating concerns that typically accompanied overweight children. The mechanisms by which early self-regulation skills and temperament-based pleasure may contribute to the development of pediatric obesity and associated weight concerns are discussed.

Toddler self-regulation skills predict risk for pediatric obesity.

OBJECTIVE: To investigate the role of early self-regulation skills, including emotion regulation, sustained attention and inhibitory control/reward sensitivity, in predicting pediatric obesity in early childhood. METHOD: Participants for this study included 57 children (25 girls) obtained from three different cohorts participating in a larger ongoing longitudinal study. At 2 years of age, participants participated in several laboratory tasks designed to assess their self-regulation skills. Height and weight measures were collected when children were 2 and 5.5 years of age. RESULTS: Self-regulation skills in toddlerhood were predictive of both normal variations in body mass index (BMI) development and pediatric obesity. Specifically, emotion regulation was the primary self-regulation skill involved in predicting normative changes in BMI as no effects were found for sustained attention or inhibitory control/reward sensitivity. However, both emotion regulation and inhibitory control/reward sensitivity predicted more extreme weight problems (that is, pediatric obesity), even after controlling for 2-year BMI. Thus, toddlers with poor emotion regulation skills and lower inhibitory control skills/higher reward sensitivity were more likely to be classified as overweight/at risk at 5.5 years of age. CONCLUSION: Early self-regulation difficulties across domains (that is, behavioral and emotional) represent significant individual risk factors for the development of pediatric obesity. Mechanisms by which early self-regulation skills may contribute to the development of pediatric obesity are discussed.

Maternal Behavior and Children's Early Emotion Regulation Skills Differentially Predict Development of Children's Reactive Control and Later Effortful Control.

The role of maternal behavior and children's early emotion regulation skills in the development of children's reactive control, specifically behavioral impulsivity, and later effortful control was examined in a sample of 435 children. HLM analyses indicated significant growth in reactive control across the toddlerhood to early childhood period. Emotion regulation at age-2 positively predicted initial levels of children's reactive control abilities while maternal overcontrol/intrusiveness predicted lower levels of reactive control growth. Maternal behaviors at age-2 predicted children's effortful control abilities at age-5.5. Emotion regulation did not predict effortful control abilities. Maternal behavior and children's early emotion regulation skills may differentially facilitate the development of reactive and effortful control abilities.

Continuity and discontinuity of behavioral inhibition and exuberance: psychophysiological and behavioral influences across the first four years of life.

Four-month-old infants were screened (N = 433) for temperamental patterns thought to predict behavioral inhibition, including motor reactivity and the expression of negative affect. Those selected (N = 153) were assessed at multiple age points across the first 4 years of life for behavioral signs of inhibition as well as psychophysiological markers of frontal electroencephalogram (EEG) asymmetry. Four-month temperament was modestly predictive of behavioral inhibition over the first 2 years of life and of behavioral reticence at age 4. Those infants who remained continuously inhibited displayed right frontal EEG asymmetry as early as 9 months of age while those who changed from inhibited to noninhibited did not. Change in behavioral inhibition was related to experience of nonparental care. A second group of infants, selected at 4 months of age for patterns of behavior thought to predict temperamental exuberance, displayed a high degree of continuity over time in these behaviors.

Physiological and behavioral regulation in two-year-old children with aggressive/destructive behavior problems.

A sample of 99 two-year-old children was selected on the basis of parents' responses to two administrations of the Child Behavior Checklist for two- to three-year-olds. Forty-nine of these children displayed symptoms of aggressive/destructive (externalizing) problems that were in the borderline clinical range (labelled "high risk") and 50 children displayed few such symptoms ("low risk"). The children were assessed in a series of laboratory procedures that were intended to be emotionally and behaviorally challenging, during which time heart rate was recorded and behavior was observed. To assess physiological regulation, resting measures of heart period and respiratory sinus arrhythmia (RSA), and heart period change and RSA suppression were derived from these procedures. To assess emotional and behavioral regulation, children's affect and on-task versus types of off-task behaviors were measured. Results indicated that children in the high-risk group did not differ from children in the low-risk group on the resting measure of heart period. Boys displayed lower heart rate than did girls, regardless of risk group. However, boys in the low-risk group differed from boys in the high-risk group in terms of resting measures of RSA. Children in the high-risk group did display significantly and consistently lower RSA suppression (physiological regulation) during the challenging situations than did the children in the low-risk group. High-risk children displayed more negative affect and dysregulated emotion regulation behaviors than did the low risk children. These findings are discussed in terms of the development of behavioral and emotional regulation that underlie adaptive versus maladaptive behavior.

Cardiac vagal tone indices of temperamental reactivity and behavioral regulation in young children.

The relation between two dimensions of vagal tone (Vna), indexed by a baseline measure of Vna and suppression of Vna and temperamental reactivity and behavioral regulation was investigated. Forty-one children were observed during a series of episodes designed to elicit temperamental reactivity and behavioral regulation. Heart rate was recorded during these baseline, positive, negative, and delay episodes, from which measures of vagal tone were computed. Across the entire sample, vagal tone decreased from the baseline episode to the three affect tasks. Baseline measures of vagal tone were related to the tendency to show a decrease in vagal tone: Children who consistently suppressed vagal tone (showed a decrease to all the affect tasks) had higher baseline vagal tone. Baseline vagal tone was related to temperamental reactivity for the positive and negative tasks, but not the delay tasks. Vagal suppression (vagal difference score) was related to several of the behavioral regulation strategies used by the children in the affect-eliciting situations. These findings are discussed in terms of the adaptive value of physiological regulation in the development of regulatory behaviors that may be critical to social development.

Behavioral and physiological antecedents of inhibited and uninhibited behavior.

4-month-old infants were specifically selected for patterns of affective and motoric reactivity that were hypothesized to be associated with later inhibited and uninhibited behavior. Infants were classified as high on motor activity and negative affect, high on motor activity and positive affect, or low on motor activity and affect. Brain electrical activity was assessed in these infants at 9 months of age, and behavior toward novelty was observed at 14 months of age. Infants who were high on motor activity and negative affect exhibited greater right frontal EEG activation at 9 months of age and inhibited behavior at 14 months of age. Infants classified as high motor/high positive at 4 months of age exhibited uninhibited behavior at 14 months of age. No relations were found between frontal asymmetry at 9 months of age and inhibited behavior at 14 months of age. However, greater activation in both the left and right frontal hemispheres was associated with higher inhibition scores at 14 months of age. These findings are discussed in terms of the role that affective and physiological reactivity may play in the development of social behavior during toddlerhood.

Frontal activation asymmetry and social competence at four years of age.

The pattern of frontal activation as measured by the ongoing electroencephalogram (EEG) may be a marker for individual differences in infant and adult disposition to respond with either positive or negative affect. We studied 48 4-year-old children who were first observed in same-sex quartets during free-play sessions, while making speeches, and during a ticket-sorting task. Social and interactive behaviors were coded from these sessions. Each child was subsequently seen 2 weeks later when EEG was recorded while the child attended to a visual stimulus. The pattern of EEG activation computed from the session was significantly related to the child's behavior in the quartet session. Children who displayed social competence (high degree of social initiations and positive affect) exhibited greater relative left frontal activation, while children who displayed social withdrawal (isolated, onlooking, and unoccupied behavior) during the play session exhibited greater relative right frontal activation. Differences among children in frontal asymmetry were a function of power in the left frontal region. These EEG/behavior findings suggest that resting frontal asymmetry may be a marker for certain temperamental dispositions.

Being alone, playing alone, and acting alone: distinguishing among reticence and passive and active solitude in young children.

3 forms of solitude were studied in young children--reticence (onlooker and unoccupied behavior), solitary-passive behavior (solitary-constructive and -exploratory play), and solitary-active behavior (solitary-functional and -dramatic play). 48 4-year-old children grouped in quartets of same-sex unfamiliar peers were observed in several situations. Mothers completed the Colorado Temperament Inventory. Results indicated that (1) solitary-passive, solitary-active, and reticent behaviors were nonsignificantly intercorrelated; (2) reticence was stable and associated with the demonstration of anxiety and hovering near others, whereas solitary-passive and solitary-active play were stable yet unrelated to anxiety and hovering; (3) reticence during free play was generally associated with poor performance and displays of wariness in several other social situations, while solitary-passive and -active play were not; (4) reticence was associated with maternal ratings of child shyness, while solitary-active behavior was associated with maternal ratings of impulsivity. Results are discussed in terms of the underlying mechanisms associated with reticence and passive and active withdrawal.

Origins and outcomes of individual differences in emotion regulation.

Recent discussions of emotion regulation in infants and young children have focused on the individual differences that exist in this domain of development. Such differences may be seen at the outcome level, in terms of variations in the development of particular strategies as a result of infant or caregiver effects. In this essay, a general hypothetical pathway to emotion regulation and dysregulation comprising interactions among a number of internal and external factors thought to impinge on the emotion regulation process has been proposed. Relations among these factors were hypothesized, and examples of pathways to particular types of social behavior in a peer setting were advanced. It is suggested that empirical confirmation of these pathways would enhance our understanding of adaptive regulatory behavioral patterns as well as patterns that may be dysregulating and potentially place the child at risk for the development of psychopathological disorders. To be successful, such studies must include consideration of the reciprocal interaction between the infant's behavioral and cognitive traits and the caregiving environment over extended periods of early development.

The relations among infant temperament, security of attachment, and behavioral inhibition at twenty-four months.

The purpose of this study was to examine the relations among infant temperament, attachment, and behavioral inhibition. 52 infants were seen at 2 days, 5, 14, and 24 months of age. Assessments were made of temperament at 2 days and 5 months of age, and attachment and behavioral inhibition were assessed at 14 and 24 months, respectively. EKG was recorded at each assessment, and measures of heart period and vagal tone were computed. Distress to pacifier withdrawal at 2 days of age was related to insecure attachment at 14 months. 2 types of distress reactivity at 5 months, reactivity to frustration and reactivity to novelty, were identified and related to high vagal tone. Attachment classification at 14 months was directly related to inhibited behavior at 24 months. Infants classified as insecure/resistant were more inhibited than those classified as insecure/avoidant. In addition, an interaction of infant reactivity to frustration and attachment classification was found to predict inhibition at 24 months. Infants classified as insecure/resistant and who had not cried to the arm restraint procedure at 5 months were the most inhibited at 24 months. These findings are discussed in terms of hypotheses regarding multiple modes of distress reactivity and regulation in early infancy and their different social and behavioral outcomes.

Does imitation facilitate the acquisition of grammar? Evidence from a study of autistic, Down's syndrome and normal children.

This paper re-opens the question of whether imitation plays a significant role in the acquisition of grammar. Data for this study came from four samples of naturalistic mother-child speech taken over the course of one year from four autistic, four Down's syndrome and four normal children, covering a range of MLU stages. In general, autistic children used more formulaic language, including imitations, than Down's syndrome children, who in turn used more than the normal children. Comparisons of imitative and spontaneous corpora from the same transcripts were made using MLU and the Index of Productive Syntax. The main findings were that, with few exceptions, spontaneous speech utterances were longer, and contained more advanced grammatical construction than did the imitation utterances. These findings held across all three groups of subjects. We conclude that imitation does not facilitate grammatical development.

A longitudinal study of language acquisition in autistic and Down syndrome children.

Findings from a longitudinal study of language acquisition in a group of autistic children are presented. Six autistic subjects and six children with Down syndrome, matched on age and MLU at the start of the study, were followed over a period of between 12 and 26 months. Language samples were collected in the children's homes while they interacted with their mothers. Samples of 100 spontaneous child utterances from the transcripts were analyzed using the following measures: MLU, Index of Productive Syntax, lexical diversity, and form class distribution. The results indicate that the majority of these autistic children followed the same general developmental path as the Down syndrome children in this study, and normal children reported in the literature, in the acquisition of grammatical and lexical aspects of language, and confirm previous findings suggesting that autism does not involve a fundamental impairment in formal aspects of language.