1.
Bioorg Med Chem
; 15(2): 771-83, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17088069
RESUMO
A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to sigma(1) and sigma(2) receptors. Many compounds exhibited nanomolar affinity for sigma(1) subtype receptor with good selectivity over sigma(2). A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussed.