Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Biochim Biophys Acta ; 1681(1): 47-52, 2004 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-15566943

RESUMO

We report the isolation of the mouse JNK/SAPKalpha gene, the determination of its exon/intron organization and the characterization of its promoter region. The mouse JNK/SAPKalpha gene spans a region of 36 kbp and contains 13 exons, which represent about 8% of the gene sequence. Major JNK/SAPKalpha splice variants (I and II) are generated by alternative splicing of exons 7 and 8, respectively, whereas minor variants (III and IV) are generated using cryptic sites located inside exon 9. The regulatory elements of the JNK/SAPKalpha gene are located in a 400-bp region placed upstream of the first exon. The gene lacks a TATA element and the initiation of transcription is located inside a 1-kbp CG island. Two regulatory regions located at -98/-69 and -69/-30 were defined by deletion analysis of the promoter.


Assuntos
Éxons/genética , Proteínas Quinases JNK Ativadas por Mitógeno/genética , Regiões Promotoras Genéticas/genética , Transcrição Gênica , Processamento Alternativo , Animais , Sequência de Bases , Camundongos , Dados de Sequência Molecular , Sequências Reguladoras de Ácido Nucleico , Deleção de Sequência , TATA Box
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...