1.
ChemMedChem
; 4(3): 335-7, 2009 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19156651
RESUMO
With a Hunsdiecker-Barton iododecarboxylation strategy, we converted the carboxylate group of the oseltamivir precursor into exemplary phosphonate monoesters. In all cases, K(i) values towards influenza virus sialidase remained in the sub-nanomolar range. We have thus made valuable structural space available for the design of novel oseltamivir-based tools for influenza virus research.