RESUMO
Clinical responses were nearly identical in a controlled double-blind study in which 131 patients with skin or soft tissue infections caused by Staphylococcus aureus received a cephalosporin antibiotic (cephradine) given twice (70 patients) or four times daily (61 patients). Satisfactory responses were obtained in approximately 95 percent of patients treated with either regimen. Eradication of S. aureus occurred within four days in 64 percent of patients in each group. These results provide critical support for the theory that antibiotics administered twice daily are as effective as the same total doses administered three or four times a day. The simplified twice daily schedule should be advantageous in obtaining patient compliance.
Assuntos
Cefalosporinas/administração & dosagem , Dermatopatias Infecciosas/tratamento farmacológico , Infecções Estafilocócicas/tratamento farmacológico , Abscesso/tratamento farmacológico , Idoso , Ensaios Clínicos como Assunto , Método Duplo-Cego , Feminino , Doenças da Gengiva/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Cooperação do Paciente , Doenças Faríngeas/tratamento farmacológicoRESUMO
The relative efficacy and safety of cephradine and cefazolin were compared in 180 patients with a variety of serious infections caused by susceptible organisms. The patients were randomly assigned to one of two groups of 90 patients each. Most patients received 2 to 4 g per day, administered by intravenous injection in four equally divided doses, for a minimum of 4 days. Based on the clinical and microbiological results, the two cephalosporins were found to be comparable in therapeutic effectiveness. Toxicity was not a problem with either drug.
Assuntos
Infecções Bacterianas/tratamento farmacológico , Cefazolina/uso terapêutico , Cefalosporinas/uso terapêutico , Cefradina/uso terapêutico , Adolescente , Adulto , Idoso , Cefazolina/administração & dosagem , Cefradina/administração & dosagem , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Injeções Intravenosas , Masculino , Pessoa de Meia-Idade , Pneumonia Pneumocócica/tratamento farmacológico , Sepse/tratamento farmacológico , Dermatopatias Infecciosas/tratamento farmacológico , Infecções Urinárias/tratamento farmacológicoRESUMO
Although it is a common belief that most antibiotics require 4 doses daily, on theoretical grounds such frequent administration may not be necessary (at least for bactericidal antibiotics) and can compromise patient compliance. In 548 patients with urinary tract infections studied under double-blind conditions, 1 g of cephradine orally twice daily provided results equivalent to those obtained with 500 mg of cephradine given 4 times a day. A total of 242 (89%) of 272 patients in the b.i.d. group and 246 (89%) of 276 patients in the q.i.d. group responded well and rapidly. The incidence of adverse reactions attributable to cephradine was equivalent in the two groups.
