1.
Nat Rev Chem
; 7(8): 534-535, 2023 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37434011
2.
J Org Chem
; 88(14): 10020-10026, 2023 Jul 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37418624
RESUMO
Five-membered ring systems are ubiquitous throughout natural products and synthetic therapeutics, and thus, efficient methods to access this essential scaffold are required. Herein, we report the thioacid-mediated, 5-exo-trig cyclization of various 1,6-dienes, with high yields of up to 98%. The labile thioester functionality can be exploited to generate a free thiol residue which can be used as a functional handle or removed entirely to provide the traceless cyclized product.