Pre-distortion adaptive optics for optical feeder links: simulations and performance analyses.

Optical feeder links offer immense utility in meeting future communication demands-however, atmospheric turbulence limits their performance. This work targets this challenge through analyses of a bidirectional free-space optical communication (FSOC) link that incorporates pre-distortion adaptive optics (AO) between the next-generation optical ground station at the German Aerospace Center (DLR) Oberpfaffenhofen and the laser communications terminal on Alphasat-a satellite in geostationary orbit (GEO). The analyses are performed via end-to-end Monte Carlo simulations that provide realistic performance estimates of the bidirectional FSOC link for a GEO feeder link scenario. We find that applying pre-distortion AO reduces the total uplink losses of the bidirectional FSOC link by up to 10 dB and lessens the scintillation at the GEO satellite by an order of magnitude. Moreover, applying pre-distortion AO eases the link budget requirements needed for maintaining 99.9% link uptime by as much as 20-40 dB, while its use with a laser guide star shows an additional performance improvement of up to 8 dB. These findings demonstrate the desirability and feasibility of utilizing pre-distortion AO for the realization of optical feeder links.

Characterizing turbulence profile layers through celestial single-source observations.

Future spacecraft missions aim to communicate with the Earth using near-infrared lasers. The possible bit rate of free-space optical communication (FSOC) is orders of magnitude greater when compared to current radio frequency transmissions. The challenge of ground-space FSOC is that atmospheric turbulence perturbs optical wavefront propagation. These wavefront aberrations can be measured using a Shack-Hartmann wavefront sensor (SHWFS). A ground-based adaptive optics (AO) system can mitigate these aberrations along the optical path by translating wavefront measurements into deformable mirror commands. However, errors result from atmospheric turbulence continuously evolving, and there are unavoidable delays during AO wavefront correction. The length of an acceptable delay is referred to as the coherence time-a parameter dependent on the strength of turbulence profile layers and their corresponding wind-driven velocity. This study introduces a novel technique, to the best of our knowledge, for using SHWFS single-source observations, e.g., the downlink signal from a geostationary satellite, to measure the strength and velocity of turbulence profile layers. This work builds upon previous research and demonstrates that single-source observations can disentangle turbulence profile layers through studying the cross-covariance of temporally offset SHWFS centroid measurements. Simulated data are used to verify that the technique can recover the coherence time. The expected and measured results have a correlation coefficient of 0.95.

Using retrospective life tables to assess the effect of extreme climatic conditions on ungulate demography.

In Mediterranean areas, severe drought events are expected to intensify in forthcoming years as a consequence of climate change. These events may increase physiological and reproductive stress of wild populations producing demographic changes and distribution shifts. We used retrospective life tables to understand demographic changes on a wild population after severe drought events. We studied the impact of two extreme events (2003 and 2005) on the population dynamics of our model species, the red deer (Cervus elaphus). During both years, population density was high (40 and 36 ind/100 ha, respectively). Thus, we reconstructed retrospectively the age structure of the female part of the population for the period 2000-2010 by using data of known-age individuals culled during the period 2000-2019 (n = 4176). Also, based on previous study results, we aimed to validate this methodology. Both extremely dry years, 2003 and 2005, produced marked and lasting cohort effects on population demography. Age pyramid the following years (2004 and 2006) revealed that the extreme drought caused the female fawn cohort to be similar or even smaller than the yearling cohort. Furthermore, these cohort effects were still perceptible 3 years after these severe events. Results agree with previous findings that showed a negative effect of severe drought events on female pregnancy rates and conception dates. Although simple, this study provides an empirical quantification of the demographic effects of severe drought events for a wild population which might be useful to understand future demographic changes under the context of climate change.

Adaptive Optics pre-compensated laser uplink to LEO and GEO.

We present the results from a Monte Carlo computer simulation of adaptive optics (AO) pre-compensated laser uplink propagation through the Earth's atmospheric turbulence from the ground to orbiting satellites. The simulation includes the so-called point-ahead angle and tests several potential AO mitigation modes such as tip/tilt or full AO from the downlink beam, and a laser guide star at the point ahead angle. The performance of these modes, as measured by metrics relevant for free-space optical communication, are compared with no correction and perfect correction. The aim of the study is to investigate fundamental limitations of free-space optical communications with AO pre-compensation and a point-ahead angle, therefore the results represent an upper bound of AO corrected performance, demonstrating the potential of pre-compensation technology. Performance is assessed with varying launch aperture size, wavelength, launch geometry, ground layer turbulence strength (i.e. day/night), elevation angle and satellite orbit (Low-Earth and Geostationary). By exploring this large parameter space we are able examine trends on performance with the aim of informing the design of future optical ground stations and demonstrating and quantifying the potential upper bounds of adaptive optics performance in free-space optical communications.

Proof of concept for adaptive sequential optimization of free-space communication receivers.

In a downlink scenario, the performance of laser satellite communications is limited due to atmospheric turbulence, which causes fluctuations in the intensity and the phase of the received signal, leading to an increase in bit error probability. In principle, a single-aperture phase-compensated receiver, based on adaptive optics, can overcome atmospheric limitations by adaptive tracking and correction of atmospherically induced aberrations. However, under strong turbulence situations, the effectiveness of traditional adaptive optics systems is severely compromised. We have developed an alternative intensity-based technique that corrects the wavefront by iteratively updating the phases of individual focal-plane speckles, which maximizes the power coupled into a single-mode fiber. Here, we present the proof of concept for this method. We show how this technique offers around 4 dB power gain with fewer than 60 power measurements under strong turbulence conditions. It delivers a good performance in different turbulent regimes, and it shows robustness against severe deterioration of the signal-to-noise ratio.

Which are the best parameters to obtain proteins and malondialdehyde from a tear sample?

Predictive, preventive and personalized medicine (PPPM) is a current concept in healthcare based on the analysis of biomarkers through non-invasive methods. Biomarkers for inflammation and oxidative stress are especially used for screening. Quantification of tear total protein content is important to identify potential, specific biomarkers, such as malondialdehyde concerning oxidative stress. The Schirmer strip test is an accessible and simple method for tear analysis. However, it is limited by the low concentration of biomarkers in the human tear. In this preliminary study, different procedures were compared for the extraction of tear proteins and malondialdehyde. Schirmer strips were used to obtain tears from healthy subjects. Ionic strength and surfactant agents were assessed, as well as different centrifugation parameters. Finally, several volumes of n-butanol on the process of malondialdehyde extraction were evaluated. The results showed that ionic strength strongly influences the extraction process, although most studies have suggested that surfactant agents are the most relevant factor; the most efficient results were obtained using a 2 M solution of NaCl in phosphate buffered saline. Regarding centrifugation, leaving the Schirmer strip tip left hanging outside the tube cap and using 1000 rpm was the best option, which is a lower centrifugation speed than the usually reported on literature. Moreover, 250 µL was the optimal n-butanol volume for malondialdehyde extraction. The importance of this study relies on the increasing relevance of the biomarkers in the field of PPPM and the need of a standardized method to extract biomarkers from the tears, to optimise its use.

Demonstration of 40 GBaud intradyne transmission through worst-case atmospheric turbulence conditions for geostationary satellite uplink.

An optical communications system employing intradyne reception and offline digital signal processing is tested over a 10.45 km link through the atmosphere. 40 GBaud transmission using binary phase-shift keying in the C-band is demonstrated and compared with laboratory measurements. Simultaneous photodetector measurements show that the turbulence in the atmospheric channel is representative for relevant and worst-case conditions in the geostationary satellite uplink scenario.

Intensity-based adaptive optics with sequential optimization for laser communications.

Wavefront distortions of optical waves propagating through the turbulent atmosphere are responsible for phase and amplitude fluctuations, causing random fading in the signal coupled into single-mode optical fibers. Wavefront aberrations can be confronted, in principle, with adaptive optics technology that compensates the incoming optical signal by the phase conjugation principle and mitigates the likeliness of fading. However, real-time adaptive optics requires phase wavefront measurements, which are generally difficult under typical propagation conditions for communication scenarios. As an alternative to the conventional adaptive optics approach, here, we discuss a novel phase-retrieval technique that indirectly determines the unknown phase wavefront from focal-plane intensity measurements. The adaptation approach is based on sequential optimization of the speckle pattern in the focal plane and works by iteratively updating the phases of individual speckles to maximize the received power. We found in our analysis that this technique can compensate the distorted phasefront and increase the signal coupled with a significant reduction in the required number of iterations, resulting in a loop bandwidth utilization well within the capacity of commercially available deformable mirrors.

Demonstration of intradyne BPSK optical free-space transmission in representative atmospheric turbulence conditions for geostationary uplink channel.

Binary phase-shift keying optical transmission in the C-band with coherent intradyne reception is demonstrated over a long-range (10.45 km) link through the atmosphere. The link emulates representative channel conditions for geostationary optical feeder uplinks in satellite communications. The digital signal processing used in recovering the transmitted data and the performed measurements are described. Finally, the bit error rate results for 10 Gbit/s, 20 Gbit/s, and 30 Gbit/s of the outdoor experiments are presented and compared with back-to-back measurements and theory.

Sensitivity modeling of binary optical receivers.

The sensitivity characteristics of optical receiver frontends for high-speed data communications depend on modulation format, detector type, and specific operational constraints. A general mathematical model of the receiver sensitivity that fits to analytical as well as measured data is required to compare different receiver implementations and assess the reliability of data links under varying received power as common in free-space optical communication links. In this paper, a new approach based on Q-factor modeling is presented, compared with analytical receiver models, and applied to a multitude of exemplary receiver implementations. A methodology is introduced to generally apply the model to ideal or practical binary optical receiver frontends.

Electronic clinical records in primary care for estimating disease burden and management. An example of COPD / La historia clínica electrónica en atención primaria en la estimación de la carga y la gestión de una enfermedad. El ejemplo de la EPOC

Chronic obstructive pulmonary disease (COPD) is a significant health problem in developed countries. We aimed to estimate the prevalence of COPD in a single Spanish healthcare area. We also aimed to assess if there are any differences in prevalence and spirometry use among primary care services by utilizing already registered information. We designed a cross-sectional study to determine the prevalence of COPD and the performance of spirometries in each primary care service. A total of 8,444 patients were diagnosed with COPD, with a prevalence of 2.6% for individuals older than 39 years. The prevalence increased with age and was much higher in men. Significant heterogeneity was found in the prevalence of COPD and spirometry use among primary care services. COPD was underdiagnosed and there was wide variability in spirometry use in our area. Greater efforts are needed to diagnose COPD in order to improve its clinical outcomes and to refine registries so that they can be used as reliable sources of information (AU)

La enfermedad pulmonar obstructiva crónica (EPOC) es un importante problema de salud en los países desarrollados. Se pretende estimar la prevalencia de la EPOC en un área sanitaria española para evaluar si existen diferencias en la prevalencia y en el uso de espirometrías entre los servicios de atención primaria utilizando información proveniente de registros. Se diseñó un estudio transversal para obtener la prevalencia de la EPOC y la realización de espirometrías en cada servicio de atención primaria. Hay 8444 pacientes diagnosticados de EPOC, con una prevalencia del 2,6% en mayores de 39 años. La prevalencia aumenta con la edad y es mucho más alta en los hombres que en las mujeres. Se observa una importante heterogeneidad en la prevalencia de la EPOC y en el uso de espirometrías entre servicios de primaria. La EPOC está infradiagnosticada y hay una fuerte variabilidad en el uso de espirometrías dentro de un área sanitaria. Deben hacerse más esfuerzos para diagnosticar la EPOC con el fin de mejorar los resultados clínicos, y refinar los registros para que puedan utilizarse como fuentes fiables de información sanitaria (AU)

Electronic clinical records in primary care for estimating disease burden and management. An example of COPD.

Chronic obstructive pulmonary disease (COPD) is a significant health problem in developed countries. We aimed to estimate the prevalence of COPD in a single Spanish healthcare area. We also aimed to assess if there are any differences in prevalence and spirometry use among primary care services by utilizing already registered information. We designed a cross-sectional study to determine the prevalence of COPD and the performance of spirometries in each primary care service. A total of 8,444 patients were diagnosed with COPD, with a prevalence of 2.6% for individuals older than 39 years. The prevalence increased with age and was much higher in men. Significant heterogeneity was found in the prevalence of COPD and spirometry use among primary care services. COPD was underdiagnosed and there was wide variability in spirometry use in our area. Greater efforts are needed to diagnose COPD in order to improve its clinical outcomes and to refine registries so that they can be used as reliable sources of information.

One-way radio frequency dissemination through the atmosphere using two optical carriers.

A method of transferring an RF reference frequency through the turbulent atmosphere is presented. Using two optical wavelengths close to each other can compensate for the influence of the atmospheric piston error. The influence of the atmosphere on the phase of the optical signal is calculated together with the remaining error by transferring two carriers. The system was implemented in a laboratory test-bed, and stability measurements are shown.

Corneal aberrations and visual acuity after laser in situ keratomileusis: femtosecond laser versus mechanical microkeratome.

PURPOSE: To compare corneal high-order aberrations and visual acuity after laser in situ keratomileusis (LASIK) with the flap created by a femtosecond laser (bladeless) to LASIK with the flap created by a mechanical microkeratome. DESIGN: Prospective, randomized, paired-eye study. METHODS: Fellow eyes of 21 patients with myopia or myopic astigmatism were randomized by ocular dominance. Corneal topography and visual acuity were measured before and at 1, 3, 6, 12, and 36 months after LASIK. Wavefront errors from the anterior corneal surface were calculated from the topography data over 4- and 6-mm-diameter pupils and decomposed into Zernike polynomials to the 6th order. RESULTS: There were no differences in corneal total high-order aberrations, spherical aberration, coma, or trefoil between methods of flap creation at any examination over 4- and 6-mm-diameter pupils. Over a 6-mm pupil, total high-order aberrations increased by 1 month after LASIK with both treatments (P