RESUMO
BACKGROUND: There is limited evidence for the benefit of olaparib in platinum-resistant ovarian cancer (PROC) patients with BRCA wild-type tumors. This study investigated whether this combination of a DNA-damaging chemotherapy plus olaparib is effective in PROC regardless BRCA status. PATIENTS AND METHODS: Patients with high-grade serous or endometrioid ovarian carcinoma and one previous PROC recurrence were enrolled regardless of BRCA status. Patients with ≤4 previous lines (up to 5 in BRCA-mut) with at least one previous platinum-sensitive relapse were included; primary PROC was allowed only in case of BRCA-mut. Patients initially received six cycles of olaparib 300 mg b.i.d. (biduum) + intravenous pegylated liposomal doxorubicin (PLD) 40 mg/m2 (PLD40) every 28 days, followed by maintenance with olaparib 300 mg b.i.d. until progression or toxicity. The PLD dose was reduced to 30 mg/m2 (PLD30) due to toxicity. The primary endpoint was progression-free survival (PFS) at 6 months (6m-PFS) by RECIST version 1.1. A proportion of 40% 6m-PFS or more was considered of clinical interest. RESULTS: From 2017 to 2020, 31 PROC patients were included. BRCA mutations were present in 16%. The median of previous lines was 2 (range 1-5). The overall disease control rate was 77% (partial response rate of 29% and stable disease rate of 48%). After a median follow-up of 10 months, the 6m-PFS and median PFS were 47% and 5.8 months, respectively. Grade ≥3 treatment-related adverse events occurred in 74% of patients, with neutropenia/anemia being the most frequent. With PLD30 serious AEs were less frequent than with PLD40 (21% versus 47%, respectively); moreover, PLD30 was associated with less PLD delays (32% versus 38%) and reductions (16% versus 22%). CONCLUSIONS: The PLD-olaparib combination has shown significant activity in PROC regardless of BRCA status. PLD at 30 mg/m2 is better tolerated in the combination.
Assuntos
Neoplasias Ovarianas , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Intervalo Livre de Doença , Doxorrubicina/análogos & derivados , Feminino , Humanos , Recidiva Local de Neoplasia/tratamento farmacológico , Recidiva Local de Neoplasia/genética , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/genética , Ftalazinas , Piperazinas , PolietilenoglicóisAssuntos
Carcinoma/diagnóstico por imagem , Radioisótopos de Flúor , Fluordesoxiglucose F18 , Imagem Multimodal , Estadiamento de Neoplasias/métodos , Neoplasias Ovarianas/diagnóstico por imagem , Tomografia por Emissão de Pósitrons , Compostos Radiofarmacêuticos , Tomografia Computadorizada por Raios X , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biomarcadores Tumorais/sangue , Carboplatina/administração & dosagem , Carcinoma/sangue , Carcinoma/tratamento farmacológico , Carcinoma/radioterapia , Carcinoma/secundário , Carcinoma/cirurgia , Terapia Combinada , Evolução Fatal , Feminino , Humanos , Histerectomia , Metástase Linfática , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Terapia Neoadjuvante , Neoplasias Ovarianas/sangue , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/patologia , Neoplasias Ovarianas/radioterapia , Neoplasias Ovarianas/cirurgia , Ovariectomia , Paclitaxel/administração & dosagem , Cuidados PaliativosAssuntos
Humanos , Feminino , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Fluordesoxiglucose F18 , Neoplasias Ovarianas , Carcinoma/complicações , Carcinoma , Imageamento por Ressonância Magnética , Metástase Linfática , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/instrumentação , Fluordesoxiglucose F18/efeitos da radiação , Neoplasias Ovarianas , Ovário/patologia , Ovário , Imuno-Histoquímica/métodosRESUMO
- Propósito: el linfoma B primario mediastínico (LBPM) es una entidad clínico-patológica diferenciada reconocida en la clasificación REAL1. Constituye una entidad agresiva, que afecta fundamentalmente a jóvenes, es potencialmente curable y presenta gran dificultad en su manejo. El tratamiento habitualmente empleado incluye tanto la quimioterapia como la radioterapia.- Material y métodos: se presenta el caso de un varón de 14 años, en el que la cirugía y los nuevos avances en el tratamiento han conseguido la curación del paciente.- Resultados y conclusiones: se revisa el tratamiento del linfoma B primario mediastínico, aportando el papel de la cirugía en los casos refractarios (AU)
Assuntos
Adolescente , Masculino , Humanos , Mediastino/patologia , Mediastino/cirurgia , Linfoma/cirurgia , Linfoma/complicações , Neoplasias do Mediastino/cirurgia , Neoplasias do Mediastino/diagnóstico , Linfoma/classificação , Linfoma/tratamento farmacológico , Linfoma/radioterapia , Tórax , Toracotomia/métodos , Biópsia/métodosAssuntos
Crise Blástica/patologia , Neoplasias da Mama/complicações , Leucemia Mielomonocítica Crônica/complicações , Linfoma não Hodgkin/complicações , Tireoidite Autoimune/complicações , Idoso , Feminino , Humanos , Leucemia Monocítica Aguda/complicações , Leucemia Monocítica Aguda/patologia , Leucemia Mielomonocítica Crônica/patologia , Linfoma não Hodgkin/patologiaRESUMO
To carry out an audit of clinical records in our center for the evaluation of the quality of care before the introduction of protocols, several prevalent conditions were selected, and among them urinary tract infections (UTI). Another aim of the study was to evaluate the autochthonous flora responsible for UTI and its resistence to commonly used antimicrobials. A series of acceptable criteria and standards were set as quality controls, and the real index was found below the preselected one in all cases. The most commonly isolated organism was E. coli, followed by Proteus, which were resistent to trimetoprim-sulfamethoxazole in 56% and 71.4% of cases, respectively. Problems of organization and knowledge, and a high resistence rate to common antimicrobials were detected; the following were suggested as measures for improvement: introduction of a protocol, need for continuing education, reduction in the care demand, health education and improvement in the antibiotic policy.