Dengue incidence and associated costs in the periods before (2000-2008) and after (2009-2013) the construction of the hydroelectric power plants in Rondônia, Brazil. / Incidência de dengue e custos associados, nos períodos anterior (2000-2008) e posterior (2009-2013) à construção das usinas hidrelétricas em Rondônia.

OBJECTIVE: to describe the incidence of dengue cases and associated costs in the period before and after the construction of the Jirau and Santo Antônio hydroelectric power plants (HPP), in Rondônia State, Brazil. METHODS: economic evaluation study, based on data from the Notifiable Diseases Information System (SINAN) and the National Hospital Information System (SIH/SUS); dengue direct costs were calculated and segmented regression analysis was carried out. RESULTS: dengue incidence mean was higher in the period after HPP construction (880.29/100,000 inhabitants) than before them (356.34/100,000 inhabitants) (p≤0.05); direct costs were estimated at US$3.47 million in the pre-construction period and US$7.1 million in the post-construction period. CONCLUSION: there was an increase in the incidence and direct costs of dengue after HPP construction; the environmental licensing process should include more detailed health impact assessments.

Incidência de dengue e custos associados, nos períodos anterior (2000-2008) e posterior (2009-2013) à construção das usinas hidrelétricas em Rondônia / Incidencia de dengue y costos asociados, en los períodos antes (2000-2008) y después (2009-2013) de la construcción de las centrales hidroeléctricas en Rondônia, Brasil / Dengue incidence and associated costs in the periods before (2000-2008) and after (2009-2013) the construction of the hydroelectric power plants in Rondônia, Brazil

Objetivo: descrever a incidência de dengue e os custos associados, nos períodos anterior (2000-2008) e posterior (2009-2013) à construção das usinas hidrelétricas (UHE) Jirau e Santo Antônio, em Rondônia, Brasil. Métodos: estudo de avaliação econômica, realizado com dados do Sistema de Informação de Agravos de Notificação (Sinan) e do Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS); calcularam-se custos diretos da dengue e utilizou-se a análise de regressão segmentada. Resultados: a média de incidência de dengue foi maior no período posterior às construções (880,29/100 mil hab.) do que no período anterior (356,34/100 mil hab.) (p≤0,05); os custos diretos foram estimados em US$3,47 milhões no período anterior e US$7,1 milhões no posterior. Conclusão: houve crescimento da incidência e dos custos diretos da dengue após as construções; o processo de licenciamento ambiental deve incluir avaliações de impacto à saúde mais detalhadas.

Objetivo: analizar la incidencia de dengue y costes asociados en el período antes y después de la construcción de centrales hidroeléctricas (CHE), estado de Rondônia, Brasil. Métodos: estudio de evaluación económica, considerando los costos directos del dengue, el número de casos notificados y las internaciones hospitalarias, con datos del Sistema Nacional de Enfermedades de Declaración Sistema de Información (Sinan) y del Sistema de Información Hospitalaria del Sistema Único de Salud (SIH-SUS), analizados por regresión lineal. Resultados: se encontraron diferencias significativas entre la tasa de incidencia en el pre (356,34/100.000 habitantes) y post-construcción (880,29/100.000 habitantes) (p≤0,05); además, los costos se estimaron en US$3.47 millones en período de pre-construcción de US$7.1 millones en el período posterior. Conclusión: se sugiere la aplicación de evaluaciones del impacto en la salud más detallada, para ayudar en el uso de los recursos y la gestión de la salud.

Objective: to describe the incidence of dengue cases and associated costs in the period before and after the construction of the Jirau and Santo Antônio hydroelectric power plants (HPP), in Rondônia State, Brazil. Methods: economic evaluation study, based on data from the Notifiable Diseases Information System (SINAN) and the National Hospital Information System (SIH/SUS); dengue direct costs were calculated and segmented regression analysis was carried out. Results: dengue incidence mean was higher in the period after HPP construction (880.29/100,000 inhabitants) than before them (356.34/100,000 inhabitants) (p≤0.05); direct costs were estimated at US$3.47 million in the pre-construction period and US$7.1 million in the post-construction period. Conclusion: there was an increase in the incidence and direct costs of dengue after HPP construction; the environmental licensing process should include more detailed health impact assessments.

Homocysteine and cysteine concentrations are modified by recent exposure to environmental air pollution in São Paulo, Brazil.

Millions of people worldwide are affected by anthropogenic air pollution derived from the combustion of fossil fuels. In this work, we tested the effects of fetal, lactation and post-weaning ambient air pollution exposure on total homocysteine (tHcy) concentrations and on a downstream pathway element, the plasma cysteine (Cys) concentration. Two similar exposure chambers (polluted and filtered chamber) were located near an area with heavy traffic in São Paulo, Brazil, and male Swiss mice were housed there from the pre-natal period until 3 months of age. Groups during fetal, lactation and adult periods of exposure were apportioned, and tHcy and Cys plasma concentrations were assessed when the animals were 3 months old. In our study, both the tHcy and Cys concentrations were decreased in groups that spent their final stage of life in polluted chambers, suggesting recent alterations in tHcy and Cys concentrations due to air pollution exposure. The possible relationship of these data with cardiovascular dysfunction is still a matter of controversy in animals; nevertheless, epigenetic mechanisms emerge as a possible issue to consider in the investigation of the link between air pollution and Hcy measurement.