Assuntos
Síndrome de Behçet/tratamento farmacológico , Imunossupressores/uso terapêutico , Proteína Antagonista do Receptor de Interleucina 1/uso terapêutico , Uveíte/tratamento farmacológico , Adulto , Síndrome de Behçet/complicações , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/imunologia , Feminino , Angiofluoresceinografia , Humanos , Resultado do Tratamento , Uveíte/diagnóstico , Uveíte/etiologia , Uveíte/imunologiaRESUMO
In this study the efficacy and safety femoral intra-arterial administration of teicoplanin in the treatment of diabetic foot infections caused by gram-positive bacteria were evaluated. Twenty-five hospitalized diabetic patients with foot ulcers or with foot ulcers and metatarsophalangeal osteomyelitis were included in the study. In the ulcers Staphylococcus aureus was present alone in 16 patients and was associated with Pseudomonas aeruginosa in 2 patients, with Candida albicans in 2, and with coagulase-negative Staphylococcus in 1 patient. In 4 patients other gram-positive bacteria were isolated. All isolated strains were resistant to various antibiotics tested. Teicoplanin, 200 mg, was administered once a day by femoral intra-arterial injection for an average period of 14.72 +/- 7.16 days (range ten to thirty-six days). Six patients were treated with an additional antibiotic intramuscularly or intravenously because of a mixed infection. At the end of the therapy microbiological assessment confirmed that gram-positive infection was eliminated in all patients. Clinical outcome demonstrated that healing occurred in 18 patients (72%) and improvement in 7 patients (28%). No adverse drug reactions were observed during the treatment. The results demonstrate that femoral intra-arterial administration of teicoplanin was highly effective in skin- and bone-infected lesions in the diabetic foot. This method may represent a further advantage in management of this severe diabetic complication.
Assuntos
Antibacterianos/administração & dosagem , Pé Diabético/complicações , Infecções por Bactérias Gram-Positivas/tratamento farmacológico , Teicoplanina/administração & dosagem , Adulto , Idoso , Bactérias/isolamento & purificação , Candida albicans/isolamento & purificação , Doença Crônica , Pé Diabético/diagnóstico , Pé Diabético/microbiologia , Avaliação de Medicamentos , Feminino , Artéria Femoral , Infecções por Bactérias Gram-Positivas/diagnóstico , Infecções por Bactérias Gram-Positivas/etiologia , Infecções por Bactérias Gram-Positivas/microbiologia , Humanos , Injeções Intra-Arteriais , Masculino , Pessoa de Meia-IdadeAssuntos
Arteriopatias Oclusivas/tratamento farmacológico , Perna (Membro)/irrigação sanguínea , Moxisilita/uso terapêutico , Teofilina/análogos & derivados , Niacinato de Xantinol/uso terapêutico , Avaliação de Medicamentos , Seguimentos , Humanos , Claudicação Intermitente/tratamento farmacológico , Masculino , Moxisilita/administração & dosagem , Niacinato de Xantinol/efeitos adversosRESUMO
Ten subjects with peripheral arterial occlusive disease were treated with buflomedil, analysing the effect of every single intravenous administration of the drug, and the effect of the administration repeated for a period of 5 days. This controlled study was aimed at evaluating the state of the peripheral blood flow, not just relating to the flowmetric parameters, but also to those more directly connected to the metabolic and functional conditions of the microcirculation. During every single administration, blood flow, skin and muscular temperatures were recorded. As concerned the drug's chronic effect, endurance limit, skin and muscular temperatures, whole blood viscosity, plasma viscosity and red cell filterability were recorded before beginning the treatment and after 15 days. The results of this study show that during a single buflomedil infusion no modifications have been observed in blood flow and muscular temperature, whereas skin temperature showed a slight increase. On the contrary, after a 15 days treatment, muscular temperature and endurance limit significantly increased, without flowmetric changes. A significant decrease in values of blood viscosity at high shear-rate was recorded too. The overall results seem to indicate that after treatment with buflomedil there is an improvement of the metabolic muscular conditions, probably due to a stimulant effect of the drug on microcirculatory blood flow.