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1.
Dalton Trans ; (48): 10914-25, 2009 Dec 28.
Artigo em Inglês | MEDLINE | ID: mdl-20023922

RESUMO

A number of new ruthenium compounds have been synthesised, isolated and characterised, which exhibit excellent cytotoxicity against a number of different human tumour cell lines including a defined cisplatin resistant cell line and colon cancer cell lines. Addition of hydrophobic groups to the ruthenium molecules has a positive effect on the cytotoxicity values. Evidence is provided that, after incubation of a ruthenium compound with a 46 mer oligonucleotide duplex and subsequent nuclease treatment, ruthenium is bound to a guanine residue.


Assuntos
Antineoplásicos/síntese química , Complexos de Coordenação/síntese química , Rutênio/química , Antineoplásicos/química , Antineoplásicos/toxicidade , Linhagem Celular Tumoral , Complexos de Coordenação/química , Complexos de Coordenação/toxicidade , Cristalografia por Raios X , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Conformação Molecular
2.
Biomaterials ; 30(29): 5403-8, 2009 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19576630

RESUMO

Saturated neoglycopolymers, prepared via tandem ROMP-hydrogenation (ROMP=ring-opening metathesis polymerization) of carbohydrate-functionalized norbornenes, are investigated as novel collagen crosslinking agents in corneal tissue engineering. The neoglycopolymers were incorporated into recombinant human collagen type III (RHC III) as collagen crosslinking agents and glycosaminoglycan (GAG) mimics. The purely synthetic nature of these composites is designed to reduce susceptibility to immunological and allergic reactions, and to circumvent the transmission of animal infectious diseases. The collagen-neoglycopolymer biomaterials exhibit higher stability to collagenase-induced biodegradation than the control materials, composites of RHC III crosslinked using EDC/NHS (EDC=1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide; NHS=N-hydroxysuccinimide). Even at this proof of concept stage, the thermal stability, enzymatic resistance, and permeability of the neoglycopolymer hydrogels are comparable or superior to those of these fully optimized control materials, which have successfully been tested clinically. Tensile strength is adequate for transplantation, but lower than that of the optimized control materials.


Assuntos
Materiais Biocompatíveis/química , Materiais Biomiméticos/química , Colágeno/química , Córnea/crescimento & desenvolvimento , Polímeros/química , Líquidos Corporais/química , Reagentes de Ligações Cruzadas/química , Módulo de Elasticidade , Humanos , Teste de Materiais , Proteínas Recombinantes/química
4.
Dalton Trans ; (5): 662-4, 2006 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-16429168

RESUMO

The title ligand ('L') in crystalline [CuBrL(2)]Br.CH(3)OH and [Cu(OH(2))L(2)]SO(4).H(2)O.CH(3)OH chelates to both the copper(II) cations and the charge-balancing anions.

5.
Inorg Chem ; 41(4): 715-26, 2002 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-11849071

RESUMO

Having isolated and characterized a series of sodium cyclopentadienide salts, we have synthesized a number of 1,1'-bis-amino-functionalized ferrocenes, 1,1'-bis-amino-functionalized ferrocene salts, and 1,1'-bis-amino-functionalized ferrocenium salts. Among these are the first crystallographically characterized examples of cyclopentadienyl units containing (piperidin-N-ylethyl)- and (pyrid-2-ylmethyl)cyclopentadienyl side chains. In the cases of some of the ferrocenes, ferrocene salts, and ferrocenium salts, there are some interesting structural features in the solid state. These include C-H...N and C-H...pi cloud interactions as well as N-H...O and N-H...F hydrogen bonds.

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