Assuntos
Doenças Cardiovasculares/prevenção & controle , Promoção da Saúde , Aspirina/uso terapêutico , Brasil , Medicina Baseada em Evidências , Feminino , Humanos , Hipertensão/prevenção & controle , Metanálise como Assunto , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto , Medição de Risco , Fatores de Risco , Resultado do TratamentoRESUMO
By daily vaginal smears, uremic rats showed significantly greater prevalence of irregular estrous cycles compared with sham-operated controls (p less than 0.02). There seems to be a correlation between the degree of renal failure and estrous cycle abnormalities. The lack of LH surge on the afternoon of proestrus, found in uremic animals, suggests a defect in the positive hypothalamic steroid feedback.
Assuntos
Estro , Falência Renal Crônica/fisiopatologia , Animais , Feminino , Hormônio Luteinizante/sangue , Nefrectomia , Ratos , Ureia/sangue , Esfregaço VaginalRESUMO
A new plethysmograph for detecting arterial pulse waves in the rat tail is described. With the objective of indirectly measuring the arterial blood pressure in small animal tails an easy-to-build plethysmographic chamber is presented. Essentially in this apparatus the atmospheric air insulated in the chamber is used as the transmitter of the volume changes caused by the arterial flow. By this methodology details of the pulse wave morphology are clearly visible, including the dicrotic notch. It is demonstrated that his chamber combines simplicity with accuracy.
Assuntos
Pletismografia/instrumentação , Ratos/fisiologia , Cauda/irrigação sanguínea , Animais , Pressão Sanguínea , Fluxo Sanguíneo RegionalRESUMO
Two groups of rats, one with surgically induced chronic renal failure and a sham-operated group were used. 10 weeks after surgery the animals were individually mated for 15 days according to 4 different schemes: uremic couple, control couple, a couple with a uremic male, and a couple with a uremic female. A second mating was allowed 18 weeks after surgery. There the uremic rats and nonfertile controls were matched against fertile controls. The experimental group showed a higher percentage of nonfertile rats, their offspring had fewer newborns and the uremic mothers had litters that weighed less at birth. In uremic males low plasma testosterone levels were detected. The analysis of plasma luteinizing hormone in the female and the delayed fertilization of uremic mothers suggest the presence of irregularities in the estrous cycle of uremic females.
