RESUMO
Severe forms of malaria are associated with systemic inflammation and host metabolism disorders; however, the interplay between these outcomes is poorly understood. Using a Plasmodium chabaudi model of malaria, we demonstrate that interferon (IFN) γ boosts glycolysis in splenic monocyte-derived dendritic cells (MODCs), leading to itaconate accumulation and disruption in the TCA cycle. Increased itaconate levels reduce mitochondrial functionality, which associates with organellar nucleic acid release and MODC restraint. We hypothesize that dysfunctional mitochondria release degraded DNA into the cytosol. Once mitochondrial DNA is sensitized, the activation of IRF3 and IRF7 promotes the expression of IFN-stimulated genes and checkpoint markers. Indeed, depletion of the STING-IRF3/IRF7 axis reduces PD-L1 expression, enabling activation of CD8+ T cells that control parasite proliferation. In summary, mitochondrial disruption caused by itaconate in MODCs leads to a suppressive effect in CD8+ T cells, which enhances parasitemia. We provide evidence that ACOD1 and itaconate are potential targets for adjunct antimalarial therapy.
Assuntos
Malária , Plasmodium , Succinatos , Humanos , Monócitos , DNA Mitocondrial/metabolismo , Antígeno B7-H1/genética , Plasmodium/genética , Plasmodium/metabolismo , Malária/metabolismo , Mitocôndrias/metabolismo , Células DendríticasRESUMO
Describe las principales características de una planta depuradora con control de emisión de olores, aerosoles y ruidos, construída en la isla de Tapia, Macao (Asia)
Assuntos
Purificação da Água , AerossóisRESUMO
Describe las principales características de una planta depuradora con control de emisión de olores, aerosoles y ruidos, construída en la isla de Tapia, Macao (Asia)
