RESUMO
Background: Malignant catarrhal fever (MCF) is a frequently fatal viral infection that affects various wild and domestic ruminants and even pigs, as recently reported. It is a disease characterized by lymphoproliferation, vasculitis and erosiveulcerative lesions in mucosa and skin. In Brazil, the virus that circulates and causes the disease has been identifi ed as OvHV-2. The aim of this study is to describe the clinicopathological changes in a cow with obliterative vasculitis caused by OvHV-2.Case: A two-year-old Gir cow with a history of intermittent diarrhea and progressive weight loss for approximately a year, which had not improved with antibiotic therapy, was euthanized and subjected to necropsy. In the necropsy, the liver was enlarged, fi rm, and had a marbled aspect all over the capsular and cut surfaces (light striations intercalated with dark areas). Cut surfaces also revealed thickening of the vessel walls, which exhibited a branched pattern. There was marked thickening of the small and large intestinal walls. The hepatic, mediastinal and mesenteric lymph nodes were enlarged. The samples were fi xed in 10% phosphate-buffered formalin, routinely processed for histology, embedded in paraffi n, cut 5-µm sections, and stained stained with hematoxylin and eosin. Additionally, sections of the liver and ileum were subjected to Massons trichrome staining. The main microscop
Background: Malignant catarrhal fever (MCF) is a frequently fatal viral infection that affects various wild and domestic ruminants and even pigs, as recently reported. It is a disease characterized by lymphoproliferation, vasculitis and erosiveulcerative lesions in mucosa and skin. In Brazil, the virus that circulates and causes the disease has been identifi ed as OvHV-2. The aim of this study is to describe the clinicopathological changes in a cow with obliterative vasculitis caused by OvHV-2.Case: A two-year-old Gir cow with a history of intermittent diarrhea and progressive weight loss for approximately a year, which had not improved with antibiotic therapy, was euthanized and subjected to necropsy. In the necropsy, the liver was enlarged, fi rm, and had a marbled aspect all over the capsular and cut surfaces (light striations intercalated with dark areas). Cut surfaces also revealed thickening of the vessel walls, which exhibited a branched pattern. There was marked thickening of the small and large intestinal walls. The hepatic, mediastinal and mesenteric lymph nodes were enlarged. The samples were fi xed in 10% phosphate-buffered formalin, routinely processed for histology, embedded in paraffi n, cut 5-µm sections, and stained stained with hematoxylin and eosin. Additionally, sections of the liver and ileum were subjected to Massons trichrome staining. The main microscop
RESUMO
Background: Malignant catarrhal fever (MCF) is a frequently fatal viral infection that affects various wild and domestic ruminants and even pigs, as recently reported. It is a disease characterized by lymphoproliferation, vasculitis and erosiveulcerative lesions in mucosa and skin. In Brazil, the virus that circulates and causes the disease has been identifi ed as OvHV-2. The aim of this study is to describe the clinicopathological changes in a cow with obliterative vasculitis caused by OvHV-2.Case: A two-year-old Gir cow with a history of intermittent diarrhea and progressive weight loss for approximately a year, which had not improved with antibiotic therapy, was euthanized and subjected to necropsy. In the necropsy, the liver was enlarged, fi rm, and had a marbled aspect all over the capsular and cut surfaces (light striations intercalated with dark areas). Cut surfaces also revealed thickening of the vessel walls, which exhibited a branched pattern. There was marked thickening of the small and large intestinal walls. The hepatic, mediastinal and mesenteric lymph nodes were enlarged. The samples were fi xed in 10% phosphate-buffered formalin, routinely processed for histology, embedded in paraffi n, cut 5-µm sections, and stained stained with hematoxylin and eosin. Additionally, sections of the liver and ileum were subjected to Massons trichrome staining. The main microscop
Background: Malignant catarrhal fever (MCF) is a frequently fatal viral infection that affects various wild and domestic ruminants and even pigs, as recently reported. It is a disease characterized by lymphoproliferation, vasculitis and erosiveulcerative lesions in mucosa and skin. In Brazil, the virus that circulates and causes the disease has been identifi ed as OvHV-2. The aim of this study is to describe the clinicopathological changes in a cow with obliterative vasculitis caused by OvHV-2.Case: A two-year-old Gir cow with a history of intermittent diarrhea and progressive weight loss for approximately a year, which had not improved with antibiotic therapy, was euthanized and subjected to necropsy. In the necropsy, the liver was enlarged, fi rm, and had a marbled aspect all over the capsular and cut surfaces (light striations intercalated with dark areas). Cut surfaces also revealed thickening of the vessel walls, which exhibited a branched pattern. There was marked thickening of the small and large intestinal walls. The hepatic, mediastinal and mesenteric lymph nodes were enlarged. The samples were fi xed in 10% phosphate-buffered formalin, routinely processed for histology, embedded in paraffi n, cut 5-µm sections, and stained stained with hematoxylin and eosin. Additionally, sections of the liver and ileum were subjected to Massons trichrome staining. The main microscop