[Occurrence of pregnancy after microsurgical treatment of sterile patients with tubo-ovarian adhesive diseases]. / Frecuencia de embarazos después de tratamiento microquirúrgico en pacientes estériles por enfermedad adherencial tuboovárica.

In the last years, the adherence adnexal disease has been increased due to pelvic infections. This may cause infertility problems depending, of the nature, extension and localization inside the pelvis. In this paper we inform the results obtained in 70 patients with adnexal adhesions to whom it was performed a salpingo-ovariolysis with microsurgery technology, with the purpose of promote the fertility. All the patients received pre, trans and postoperative support (Heparin, steroids and antimicrobials). The minimal time of postoperative observation was at least 6 months. In 27 (Group I) of the 70 cases (38.6%), the adherences were avascular (IA & IIA based on Hulka's classification); and in the 43 patients of the group II (61.4%), the lesions were dense and vascular (IB & IIB). In group I, 15 pregnancies were obtained (55.6%), 13 at term, 1 miscarriage and 1 ectopic pregnancy; in the group II we documented 9 pregnancies (20.9%), 5 at term, 4 miscarriage (I trimester).

[Serum concentrations of estradiol and testosterone in patients with oligoasthenozoospermia and asthenozoospermia]. / Concentraciones séricas de estradiol y testosterona en pacientes con oligoastenozoospermia y astenozoospermia.

In order to study the possible influence of circulating concentrations of estradiol (E2) and testosterone (T) on the spermatogenesis, 43 subjects, 21 to 43 years of age; 16 of them with oligoasthenozoospermia; 16 with "pure" asthenozoospermia, and 11 with normal semen study, were studied. This last group was taken as control for results evaluation and comparison. In all the cases, the presence of genitourinary infection, as well as testicular lesions and varicocele, was previously discarded. Serum concentrations of estradiol, testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL), were determined by radio-analysis, in fasting blood samples. The results are shown as average values +/- standard error (mean +/- SE). Statistical analysis of differences between the groups, was done by "t" Student test in paired samples. Patients with oligoasthenozoospermia showed a significant increase (56.9%) (less than 0.001) in estradiol circulating levels, while T, FSH, LH and PRL concentrations were below normal band, and there were not significant differences between the three groups. These results suggest that the excess of estradiol or of some of its metabolites could affect normal production of spermatozoa, maybe due to a direct effect on germinal epithelium of testicle.

[Tissue distribution of progesterone-7-H3 in the female genital tract 8 hours after intravenous administration]. / Depósito tisular de progesterona-7-H3 en el aparato reproductor femenino, ocho horas después de su administración endovenosa.

PIP: 6 patients, ages 32-55 years, were selected to establish radioactive progesterone distribution in the genital tract, and deposition in skin and fat tissue. 1/2 of the patients were in the menstrual proliferative phase, and the rest were in the secretory phase. 250 uci of progesterone-7-h cubed was given intravenously to all patients, and total hysterectomy and salpingo-oophorectomy were performed 8 hours later. A piece of skin was taken as well as some fat tissue from the anterior abdominal wall. The tissues studied were skin, fat tissue, ovary, tube, and uterus. The uterus was sectioned into 3 parts (superior, median, inferior) and the cervix was sectioned into 2 (endocervix and ectocervix). In all the patients, urine was collected during 3 consecutive days and at the time of operation; 10 ml was taken then and at the 5th postoperative day. The largest concentration of radioactive material was found in the proliferative phase patients (in fat tissue); in the secretory phase it was concentrated in the skin, uterus, and myomas. Excretion of radioactive material was 32.5% in the urine, blood radioactivity at the time of operation was 2.62%, and 0.33% of the administered total dose at the 5th postoperative day. In a previous similar study with chlormadinone acetate, urinary excretion was 17.5% and the largest radioactive material concentration occurred in fat tissue, regardless of the day of the cycle. These results may show that natural and synthetic hormones have different action mechanisms at their genital effectors, and different fat tissue deposition. (author's)^ieng