Investigations on prolonged release of vitamin C formulations.

In this study, investigations have been carried out to prepare prolonged release formulations of ascorbic acid in order to obtain a more effective dissolution profile of the drug. For the preparation of micropellets, the fluid bed method was chosen and to obtain prolonged effect, aqueous dispersions of Eudragit S, L and their mixtures were used. After setting the parameters of fluid bed, micropellets were produced using different coating dispersions. Following the production process, morphology, friability, particle size distribution, flow properties, bulk density and dissolution tests were carried out on the micropellets. The most appropriate formulation for our aim was chosen according to these tests.

Formulation studies on modified releasing amoxicillin trihydrate microcapsules.

In vitro researches and in vivo animal experiments show that, generally the antibiotic concentration should be above minimum inhibitory concentration for optimal efficiency. There is also direct and indirect evidence from human trials to support this claim. Consequently, a modified-release dosage form of the beta-lactam antibiotics might be therapeutically more efficient than the existing conventional products, which are rapidly absorbed to produce transient peaks in serum drug levels. In our study, Amoxicillin was chosen as the model drug, because it is currently one of the most widely prescribed oral semisynthetic penicillins. By using various types of polymers and different formulations of them, we tried to improve a microparticular system. We succeeded in obtaining optimal production of particulars in the prepared microcapsule form with the solvent evaporation technique. By applying suitable pharmaceutical technological production parameters, the production of the dosage form which releases modified-release form of the model antibiotic is provided. Production processes and availability for the aim is controlled by using the pharmaceutical technological tests, mainly with the methods according to USP XXIV. Consequently compared to the classical Amoxicillin trihydrate dosage forms used in treatment, we managed to form the microcapsule structure containing modified release.

[The antifungal effects of tioconazole aerosol form]. / Tiokonazol'un aerosol tipindeki ilaç seklinin antifungal etkinliginin arastirilmasi.

In this study antifungal effects of tioconazole which is prepared in aerosol forms were investigated. For this purpose, the formulations which have and have not active material were sprayed on petri dishes inoculated with Candida albicans and Aspergillus niger. Because of non growth in dishes with formulations containing active material, formulations with active material were sprayed on to the pregrowth Candida albicans and Aspergillus niger in order to detect if the effect is fungicide or not. At the end of application time, the samples taken from these dishes were inoculated by the direct way. The lack of growth had confirmed the realization of the formulations with fungicide effects.